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61,005 resultsShowing papers similar to In vivo biotoxicological assessment of nanoplastics and microplastics predicted using the zebrafish model
ClearResearch progress of model animal zebrafish in toxicity evaluation of microplastics
This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.
Nanoplastics in the Environment and the Effects on the Zebrafish
This study reviewed the effects of nanoplastic exposure on zebrafish, covering how these tiny particles affect development, organ function, behavior, and reproductive success. Zebrafish are a widely used model organism for toxicology, and findings in this species provide insight into potential effects in other vertebrates including humans.
Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
Zebrafish: An emerging model to study microplastic and nanoplastic toxicity
This review highlights zebrafish as an increasingly valuable model organism for studying the toxic effects of micro- and nanoplastics due to their transparent embryos, genetic similarity to humans, and ease of laboratory use. Researchers summarized existing zebrafish studies showing that plastic particles can cross biological barriers and accumulate in tissues, causing various toxic effects. The study positions zebrafish research as a key tool for advancing our understanding of how plastic particle exposure affects living organisms.
Zebrafish embryos as a biological model to study the effects of nanoplastics
This study used zebrafish embryos as a model system to investigate the toxic effects of nanoplastics, finding developmental disruptions at concentrations relevant to environmental exposure. Zebrafish embryos are a widely used model because their transparency allows direct visualization of organ development during toxicant exposure.
Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles
This review summarizes research on how various nanomaterials, including nano-sized plastics, affect zebrafish, which are commonly used as stand-ins for studying human health effects. Exposure to nanomaterials caused developmental defects, organ damage, behavioral changes, and reproductive problems in zebrafish. These findings help scientists understand the potential health risks of nanomaterial exposure to humans and the environment.
A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model
This review assessed zebrafish as a model for studying nanomaterial neurotoxicity, summarizing evidence that various engineered nanoparticles including those associated with plastics can impair zebrafish neural development, behavior, and neurotransmitter systems. The authors highlighted zebrafish as particularly useful for rapid in vivo screening of nanomaterial neurological effects.
From particle size to brain function: a zebrafish-based review of micro/nanoplastic-induced neurobehavioral toxicity and mechanistic pathways
This review uses zebrafish as a model to examine how micro- and nanoplastics cause neurobehavioral toxicity, linking particle size to brain function disruption. Researchers summarize evidence that these plastic particles impair fish behavior and cause molecular-level damage in the nervous system. The findings highlight the growing concern that micro- and nanoplastics are emerging neurotoxicants in aquatic environments.
Zebrafish as a Model Organism to Study Nanomaterial Toxicity
This review examines the use of zebrafish as a model organism for studying nanomaterial toxicity, summarizing how zebrafish embryo and larval assays have been applied to assess the biological effects of metal, carbon, and polymer-based nanomaterials.
Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos
This review summarizes research on how micro- and nanoplastics harm embryo development using zebrafish as a model organism that shares genetic similarities with humans. Studies show these tiny plastic particles cause damage to the brain, heart, gut, and immune system of developing embryos, largely through oxidative stress and cell death pathways.
Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics
This review summarizes existing research on how micro- and nanoplastics affect the behavior and reproductive health of zebrafish, a common lab model for studying human biology. The findings suggest that tiny plastic particles can disrupt reproductive behavior and act as hormone-like chemicals, and that behavioral changes in fish may serve as early warning signs of reproductive harm that could be relevant to understanding human health risks.
Advantages of the zebrafish (Danio rerio) model in solving contemporary problems of neurotoxicity, teratotoxicity and genotoxicity of xenobiotics
This paper is not about microplastics per se; it is a Polish-language review of the zebrafish (Danio rerio) model in toxicology, covering its use for assessing neurotoxicity, teratotoxicity, and genotoxicity of xenobiotics including nanoparticles and microplastics, with discussion of the micronucleus and comet assays used to detect genetic damage.
Danio rerio as a Model Animal for Assessing Microplastic Toxicity
This review examines the use of zebrafish as a model organism for assessing microplastic toxicity, summarizing experimental findings across polymer types and sizes showing that microplastic exposure induces epithelial damage, lipid metabolism disruption, reproductive impairment, and neurobehavioral alterations, and discussing the strengths and limitations of Danio rerio for microplastic hazard assessment.
Research Progress of Zebrafish Model in Aquatic Ecotoxicology
This review examines how zebrafish are used as model organisms to study the toxic effects of environmental pollutants in water, including microplastics. Zebrafish are ideal because they reproduce quickly, are inexpensive to maintain, and allow researchers to study effects at the genetic, cellular, and whole-organism level. The paper provides a reference guide for scientists choosing model animals for aquatic toxicology research.
The Zebrafish as an Alternative Animal Model for Ecotoxicological Research and Testing
This review highlights zebrafish as a valuable model for studying the toxic effects of environmental contaminants, including microplastics, because they share many biological pathways with humans. Zebrafish embryos, larvae, and adults can be used to screen for harmful effects of pollutants quickly and at multiple life stages. The approach helps researchers understand how microplastics and other environmental contaminants might affect human health without requiring direct human testing.
Comprehensive review of ecological risks and toxicity mechanisms of microplastics in freshwater: Focus on zebrafish as a model organism
This comprehensive review examines how microplastics affect zebrafish, a widely used laboratory model, covering impacts on the gut, liver, reproductive system, nervous system, and immune function. Researchers found that microplastics can cause oxidative stress, inflammation, and disruption of gut bacteria across multiple organ systems. The review highlights that zebrafish studies provide valuable insights into the biological mechanisms by which microplastics may affect freshwater organisms and, potentially, human health.
A current perspective on the relevance of nano and microplastics in the neurodevelopmental disorders: further relevance for metabolic, gastrointestinal, oxidative stress-related and zebrafish studies
This review examines evidence that micro- and nanoplastics may affect brain development and neurological function, drawing on studies in zebrafish and other animal models. The authors discuss potential mechanisms including oxidative stress and endocrine disruption, and call for more research on the neurodevelopmental risks of plastic particle exposure.
Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: A review
This review summarizes research on how microplastic ingestion affects zebrafish, a popular lab animal that shares genetic similarities with humans. Studies show that microplastics cause a range of harmful effects in zebrafish, including abnormal behavior, oxidative stress, immune disruption, and reproductive problems, with smaller particles and higher concentrations causing the most damage. Since zebrafish are used as a model for human health, these findings raise concerns about what similar exposure levels could mean for people.
Zebrafish as Model Organism in Aquatic Ecotoxicology: Current Trends and Future Perspectives
This review assessed zebrafish as model organisms for aquatic ecotoxicology, summarizing current trends and future directions in using Danio rerio to study the effects of environmental pollutants including microplastics. The authors highlight the zebrafish model's utility for integrating molecular, cellular, and whole-organism responses.
Use of zebrafish (Danio rerio) as a model for research in toxicological studies
This review explains why zebrafish (Danio rerio) are a valuable model organism for toxicology research, summarizing how their biology, genetics, and organ systems resemble those of humans enough to yield insights about human health risks. Zebrafish are widely used in microplastic toxicology studies, and this review provides context for understanding the significance of zebrafish findings for human health. The paper covers applications across disease modeling and environmental toxicology.
Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism
Researchers used zebrafish as a model organism to study the toxic effects of polystyrene nanoplastics at both cellular and whole-organism levels. They found that smaller nanoplastic particles were taken up more readily by cells and caused greater oxidative stress and developmental abnormalities than larger particles. The study confirms that particle size is a critical determinant of nanoplastic toxicity, with the smallest particles posing the greatest biological risks.
O Modelo Zebrafish e sua Contribuição ao Meio Ambiente
This Brazilian review examined zebrafish as a model organism for testing water quality and the toxicity of micropollutants including microplastics in wastewater. Zebrafish are increasingly used as a standard test system for evaluating the biological effects of microplastic exposure because their genetics and physiology closely mirror human responses.
Neurotoxicity of Some Environmental Pollutants to Zebrafish
This review examines how environmental pollutants including microplastics, pesticides, and drug residues can damage the nervous system, using zebrafish as a model organism. The studies show that microplastics can cause neurotoxic effects on their own and also increase the brain-damaging potential of other pollutants they carry, which has implications for understanding how these contaminants might affect the human nervous system.
Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review
This systematic review examines how zebrafish and fruit flies are being used as model organisms to study the effects of micro- and nanoplastics on living systems. These animal models help researchers understand how plastic particles interact with biological tissues, providing insights that are relevant to potential human health effects.