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Neurotoxicity of Some Environmental Pollutants to Zebrafish
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This review examines how environmental pollutants including microplastics, pesticides, and drug residues can damage the nervous system, using zebrafish as a model organism. The studies show that microplastics can cause neurotoxic effects on their own and also increase the brain-damaging potential of other pollutants they carry, which has implications for understanding how these contaminants might affect the human nervous system.
The aquatic environment encompasses a wide variety of pollutants, from plastics to drug residues, pesticides, food compounds, and other food by-products, and improper disposal of waste is the main cause of the accumulation of toxic substances in water. Monitoring, assessing, and attempting to control the effects of contaminants in the aquatic environment are necessary and essential to protect the environment and thus human and animal health, and the study of aquatic ecotoxicology has become topical. In this respect, zebrafish are used as model organisms to study the bioaccumulation, toxicity, and influence of environmental pollutants due to their structural, functional, and material advantages. There are many similarities between the metabolism and physiological structures of zebrafish and humans, and the nervous system structure, blood-brain barrier function, and social behavior of zebrafish are characteristics that make them an ideal animal model for studying neurotoxicity. The aim of the study was to highlight the neurotoxicity of nanoplastics, microplastics, fipronil, deltamethrin, and rotenone and to highlight the main behavioral, histological, and oxidative status changes produced in zebrafish exposed to them.
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This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model
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This review assessed zebrafish as a model for studying nanomaterial neurotoxicity, summarizing evidence that various engineered nanoparticles including those associated with plastics can impair zebrafish neural development, behavior, and neurotransmitter systems. The authors highlighted zebrafish as particularly useful for rapid in vivo screening of nanomaterial neurological effects.
From particle size to brain function: a zebrafish-based review of micro/nanoplastic-induced neurobehavioral toxicity and mechanistic pathways
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This review uses zebrafish as a model to examine how micro- and nanoplastics cause neurobehavioral toxicity, linking particle size to brain function disruption. Researchers summarize evidence that these plastic particles impair fish behavior and cause molecular-level damage in the nervous system. The findings highlight the growing concern that micro- and nanoplastics are emerging neurotoxicants in aquatic environments.
Microplastic-induced neurotoxicity in Zebrafish: Current evidence and underlying mechanisms
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This review pulls together existing research showing that microplastics can build up in the brains of zebrafish (a common lab fish used to study biology similar to humans), causing damage to brain cells, disrupting chemical signals, and triggering changes in behavior like increased anxiety. While this research is in fish, not humans, it raises real concerns about what these tiny plastic particles—which we're increasingly exposed to through food and water—might be doing to our own brains, and signals a need for more research on this front.
Research progress of model animal zebrafish in toxicity evaluation of microplastics
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This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.
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