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Nanoplastics in the Environment and the Effects on the Zebrafish
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This study reviewed the effects of nanoplastic exposure on zebrafish, covering how these tiny particles affect development, organ function, behavior, and reproductive success. Zebrafish are a widely used model organism for toxicology, and findings in this species provide insight into potential effects in other vertebrates including humans.
Plastic is one of the most used materials in the world, adopted in almost all activities of human life, but due to the high persistence and durability in the environment, it is causing pollution problems. Through different processes, small particles of polymers are emerging and the effects on the health are still unknown. The Danio rerio (zebrafish) is a model organism that serves as a reference for the assessment of the safety of Nanoplastics (NPs) and Microplastics (MPs). The effects on development, central nervous system, behavior and genetic regulation, are some of the evidences that are already available thanks to the studies developed in recent years. The potential exacerbation of toxicity by co-exposure of the NPs and MP with other contaminants has been demonstrated through several studies. Furthermore, the challenge that must be overcome is the lack of uniformity in the analytical methodology that helps to generate conclusive and parallel results.
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Zebrafish embryos as a biological model to study the effects of nanoplastics
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This study used zebrafish embryos as a model system to investigate the toxic effects of nanoplastics, finding developmental disruptions at concentrations relevant to environmental exposure. Zebrafish embryos are a widely used model because their transparency allows direct visualization of organ development during toxicant exposure.
In vivo biotoxicological assessment of nanoplastics and microplastics predicted using the zebrafish model
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This review summarises zebrafish studies on the toxicity of nanoplastics and microplastics, covering developmental, reproductive, neurological, and organ-level effects. It discusses how findings in this widely used model organism may predict human health outcomes and calls for standardised exposure protocols.
Zebrafish: An emerging model to study microplastic and nanoplastic toxicity
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This review highlights zebrafish as an increasingly valuable model organism for studying the toxic effects of micro- and nanoplastics due to their transparent embryos, genetic similarity to humans, and ease of laboratory use. Researchers summarized existing zebrafish studies showing that plastic particles can cross biological barriers and accumulate in tissues, causing various toxic effects. The study positions zebrafish research as a key tool for advancing our understanding of how plastic particle exposure affects living organisms.
Research progress of model animal zebrafish in toxicity evaluation of microplastics
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This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.
Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
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This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
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