Papers

61,005 results
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Article Tier 2

Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos

Researchers studied the bioaccumulation of polystyrene nanoplastics in zebrafish embryos and their interaction with gold ions. They found that smaller nanoplastics readily penetrated the embryo's protective membrane and accumulated in lipid-rich regions, particularly the yolk. While nanoplastics alone caused only marginal toxic effects, their presence synergistically amplified the toxicity of gold ions through increased oxidative stress and inflammatory responses, suggesting that nanoplastics may worsen the harmful effects of co-occurring environmental contaminants.

2018 Nanoscale 329 citations
Article Tier 2

Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development

Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.

2023 Fishes 17 citations
Article Tier 2

Correction: Correlation between cellular uptake and cytotoxicity of polystyrene micro/nanoplastics in HeLa cells: A size-dependent matter

This is a correction notice for a previously published study on the correlation between cellular uptake and cytotoxicity of polystyrene micro- and nanoplastics.

2023 PLoS ONE 5 citations
Article Tier 2

Bioaccumulation of various nanoplastic particles in larval zebrafish (Danio rerio)

Researchers exposed larval zebrafish (Danio rerio) to 40-60 nm and 100 nm polystyrene nanoplastic particles using standard fish embryo toxicity and general behavioral toxicity assays from 6-120 hours post-fertilization, combining toxicity endpoints with fluorescence microscopy to confirm particle uptake and excretion. The study demonstrated nanoplastic accumulation within zebrafish larvae at tested concentrations, providing mechanistic insights into aquatic organism exposure dynamics for nanoplastics.

2022 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Using visualization techniques to assess the accumulation of nanoplastics with varying surface modifications

Researchers synthesized fluorescent PMMA nanoplastic particles to study cellular uptake and biodistribution in skin cells and zebrafish embryos, finding that PMMA nanoparticles can enter embryos and accumulate in larval bodies, and highlighting concerns that surface modifications on commercial polystyrene particles may produce misleading results in nanoplastic toxicity studies.

2023 1 citations
Article Tier 2

Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene

Researchers demonstrated maternal transfer of polystyrene nanoplastics in zebrafish by feeding exposed females and detecting particles in yolk sacs, livers, and guts of offspring, finding that transferred nanoplastics reduced antioxidant enzyme activity and caused bradycardia in embryos without major effects on overall reproductive success.

2018 The Science of The Total Environment 391 citations
Article Tier 2

Polystyrene nanoplastics (20 nm) are able to bioaccumulate and cause oxidative DNA damages in the brain tissue of zebrafish embryo (Danio rerio)

Researchers microinjected 20-nanometer polystyrene nanoplastics into zebrafish embryos to simulate dietary or maternal exposure and tracked their fate over 120 hours. The study found that nanoplastics reached and bioaccumulated in the brain, causing oxidative DNA damage in the regions where they accumulated. The research team used transmission electron microscopy to image nanoplastics in a vertebrate brain for the first time, also observing increased mortality, developmental abnormalities, and elevated reactive oxygen species.

2019 NeuroToxicology 316 citations
Article Tier 2

Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next

This review integrates findings from studies on how polystyrene nanoplastics affect zebrafish embryo development, a widely used model for understanding toxicity. Researchers found that the functional coating on nanoplastic surfaces had a greater influence on toxic effects than particle size or concentration alone. The study highlights that surface chemistry is a critical and often overlooked factor in nanoplastic toxicity, and calls for more standardized study designs to improve comparability across research.

2021 The Science of The Total Environment 105 citations
Article Tier 2

Polystyrene nanoplastics mediated the toxicity of silver nanoparticles in zebrafish embryos

Researchers studied how polystyrene nanoplastics interact with silver nanoparticles and affect zebrafish embryo development. They found that nanoplastics can act as carriers for silver nanoparticles in water, and the combination altered patterns of oxidative stress, immune response, and metabolic function compared to either pollutant alone. The study highlights how nanoplastics may change the way other environmental contaminants affect aquatic organisms.

2023 Frontiers in Marine Science 19 citations
Article Tier 2

Correction: Correlation between cellular uptake and cytotoxicity of polystyrene micro/nanoplastics in HeLa cells: A size-dependent matter

This is a correction notice for a published article on polystyrene micro/nanoplastic cytotoxicity and cellular uptake in HeLa cells; it does not report new findings but corrects identified errors in the original publication (DOI: 10.1371/journal.pone.0289473).

2025 PLoS ONE
Article Tier 2

Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos

Researchers found that acute polystyrene nanoplastic exposure impaired skin cells and ion regulation in zebrafish embryos, disrupting keratinocyte and ionocyte function, which are critical for maintaining osmotic balance during early development.

2022 Aquatic Toxicology 28 citations
Article Tier 2

Effects of polystyrene nanoplastics on the bioaccumulation, distribution and parental transfer of ethylhexyl salicylate

Researchers found that polystyrene nanoplastics affect the bioaccumulation and distribution of the UV filter ethylhexyl salicylate in zebrafish, and that nanoplastics facilitate the parental transfer of this chemical contaminant to offspring.

2022 Environmental Science Nano 30 citations
Article Tier 2

Polystyrene Nanoplastic Exposure Adversely Affects Survivability of Zebrafish Larvae

Researchers found that polystyrene nanoplastic exposure significantly reduces survival rates of zebrafish larvae in a dose-dependent manner, documenting behavioral abnormalities and developmental defects that highlight the toxicity of nanoscale plastic particles to early vertebrate life.

2024 Journal of Student Research
Article Tier 2

Polystyrene microplastics inhibit the neurodevelopmental toxicity of mercury in zebrafish (Danio rerio) larvae with size-dependent effects

Researchers found that polystyrene microplastics paradoxically reduced mercury neurotoxicity in zebrafish larvae, with nanoscale particles providing greater protection than microscale ones by decreasing mercury bioavailability and oxidative damage.

2022 Environmental Pollution 22 citations
Article Tier 2

Polystyrene nanoplastics: optimized removal using magnetic nano-adsorbent and toxicity assessment in zebrafish embryos

Researchers developed magnetic nanoparticles made from fly ash to remove polystyrene nanoplastics from water, achieving strong adsorption capacity under optimized conditions. They also tested the toxicity of these nanoplastics on zebrafish embryos and found they caused developmental abnormalities including reduced heart rates and hatching delays. The study highlights both a promising cleanup method and the ecological dangers that nanoplastic pollution poses to aquatic life.

2024 Journal of Environmental Health Science and Engineering 5 citations
Article Tier 2

The role of nanoplastics on the toxicity of the herbicide phenmedipham, using Danio rerio embryos as model organisms

Researchers found that polystyrene nanoplastics altered the toxicity of the herbicide phenmedipham to zebrafish embryos, with combined exposure producing different developmental effects than either contaminant alone, suggesting nanoplastics can modify pesticide bioavailability.

2022 Environmental Pollution 22 citations
Article Tier 2

Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)

Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.

2022 ACS Omega 90 citations
Article Tier 2

Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos

Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.

2023 The Science of The Total Environment 99 citations
Article Tier 2

Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption

Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.

2025 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 1 citations
Article Tier 2

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.

2020 International Journal of Molecular Sciences 410 citations
Article Tier 2

Effects of nanoplastics on zebrafish embryo-larval stages: A case study with polystyrene (PS) and polymethylmethacrylate (PMMA) particles

Researchers assessed the effects of polystyrene and polymethylmethacrylate nanoparticles on zebrafish embryos and larvae over 96 hours. The study found that these nanoplastics affected biochemical endpoints related to neurotransmission, antioxidant status, oxidative damage, and energy metabolism, with effects varying by plastic type. Evidence suggests that smaller plastic particles may have increased bioavailability and reactivity compared to larger fragments.

2022 Environmental Research 53 citations
Article Tier 2

Polystyrene nanoplastics enhance the toxicological effects of DDE in zebrafish (Danio rerio) larvae

Researchers found that polystyrene nanoplastics enhanced the toxicity of the pesticide metabolite DDE in zebrafish larvae, with co-exposure causing greater developmental abnormalities and oxidative stress than either pollutant alone.

2022 The Science of The Total Environment 38 citations
Article Tier 2

Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)

Researchers tracked the uptake and distribution of polystyrene nanoparticles in developing zebrafish and found that the particles accumulated in the yolk sac and then spread to the brain, liver, heart, and other organs. While the nanoparticles did not cause significant mortality or deformities, they did reduce heart rate and alter swimming behavior. The study suggests that nanoplastics can penetrate biological barriers and accumulate in multiple tissues during early development.

2017 Aquatic Toxicology 614 citations
Article Tier 2

Polystyrene nanoplastics accumulate in ZFL cell lysosomes and in zebrafish larvae after acute exposure, inducing a synergistic immune response in vitro without affecting larval survival in vivo

Polystyrene nanoplastics were shown to be internalized in zebrafish liver cells and accumulate in lysosomes, and while they triggered an immune response in cell cultures, they did not affect larval zebrafish survival in short-term exposures. This suggests that cellular toxicity may not always translate directly to whole-organism mortality at acute exposure levels.

2020 Environmental Science Nano 54 citations