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Polystyrene nanoplastics mediated the toxicity of silver nanoparticles in zebrafish embryos
Summary
Researchers studied how polystyrene nanoplastics interact with silver nanoparticles and affect zebrafish embryo development. They found that nanoplastics can act as carriers for silver nanoparticles in water, and the combination altered patterns of oxidative stress, immune response, and metabolic function compared to either pollutant alone. The study highlights how nanoplastics may change the way other environmental contaminants affect aquatic organisms.
The widespread distribution of nanoplastics and nanomaterials in aquatic environments is of great concern. Nanoplastics have been found to modulate the toxicity of other environmental pollutants in organisms, while few studies have focused on their influences on nanomaterials. Thus, this study evaluated the influences of polystyrene (PS) nanoplastics on the toxicity of silver nanoparticles (AgNPs) to zebrafish ( Danio rerio ) embryos, including acute toxicity, oxidative stress, apoptosis, immunotoxicity, and metabolic capability. The results showed that the presence of PS nanoplastics could act as a carrier of the co-existing AgNPs in waters. The release ratio of Ag + from AgNPs was up to 4.23%. The lethal effects of AgNPs on zebrafish embryos were not significantly changed by the co-added PS nanoplastics. Whereas, the alterations in gene expression related to antioxidant and metabolic capability in zebrafish ( sod1 , cat , mt2 , mtf-1 , and cox1 ) caused by AgNPs were significantly enhanced by the presence of PS nanoplastics, which simultaneously lowered the apoptosis and immunotoxicity ( caspase9 , nfkβ , cebp , and il-1β ) induced by AgNPs. It suggests the presence of PS nanoplastics suppressed the AgNPs-induced genotoxicity in zebrafish. The released Ag + from AgNPs may be responsible for the toxicity of AgNPs in zebrafish, while the subsequent absorption and agglomeration of AgNPs and the released Ag + on PS nanoplastics may alleviate the toxicity.