Polystyrene nanoplastics accumulate in ZFL cell lysosomes and in zebrafish larvae after acute exposure, inducing a synergistic immune response in vitro without affecting larval survival in vivo

Summary

Polystyrene nanoplastics were shown to be internalized in zebrafish liver cells and accumulate in lysosomes, and while they triggered an immune response in cell cultures, they did not affect larval zebrafish survival in short-term exposures. This suggests that cellular toxicity may not always translate directly to whole-organism mortality at acute exposure levels.