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61,005 resultsShowing papers similar to Polystyrene nanoplastics (20 nm) are able to bioaccumulate and cause oxidative DNA damages in the brain tissue of zebrafish embryo (Danio rerio)
ClearNeurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.
Polystyrene nanoplastics induce developmental impairments and vasotoxicity in zebrafish (Danio rerio)
Zebrafish exposed to polystyrene nanoplastics at environmentally realistic concentrations showed developmental problems including heart defects, brain abnormalities, blood vessel damage, and reduced swimming ability. The nanoplastics accumulated on the fish's body and triggered cell damage and oxidative stress even at very low doses. Since zebrafish are commonly used to model human developmental processes, these findings raise concerns about what nanoplastic exposure could mean for early human development.
Polystyrene nanoplastics cause developmental abnormalities, oxidative damage and immune toxicity in early zebrafish development
Zebrafish embryos exposed to polystyrene nanoplastics showed dose-dependent developmental problems including delayed hatching, reduced survival, smaller body size, and the nanoplastics accumulated in critical organs like the eyes, heart, liver, and brain. The particles triggered oxidative stress that damaged cells and activated inflammatory immune responses, demonstrating how nanoplastic contamination in water can cause widespread harm to developing organisms.
Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption
Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.
Exposure to Polystyrene Nanoplastics Led to Learning and Memory Deficits in Zebrafish by Inducing Oxidative Damage and Aggravating Brain Aging
Zebrafish exposed to polystyrene nanoplastics developed significant learning and memory problems, taking longer to navigate mazes and showing signs of accelerated brain aging. The nanoplastics caused oxidative damage, energy shortages, and disrupted the cell cycle in brain tissue. This study adds to growing evidence that nanoplastics small enough to cross the blood-brain barrier could impair cognitive function, raising concerns about long-term brain health effects from environmental nanoplastic exposure.
Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)
Researchers tracked the uptake and distribution of polystyrene nanoparticles in developing zebrafish and found that the particles accumulated in the yolk sac and then spread to the brain, liver, heart, and other organs. While the nanoparticles did not cause significant mortality or deformities, they did reduce heart rate and alter swimming behavior. The study suggests that nanoplastics can penetrate biological barriers and accumulate in multiple tissues during early development.
Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development
Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.
Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and measured gene expression changes related to stress, inflammation, and DNA repair. They found dose-dependent activation of oxidative stress and apoptotic pathways at the highest concentration, along with inhibition of the neurotransmitter-related gene acetylcholinesterase and DNA repair genes. The study suggests that nanoplastic exposure at the molecular level may compromise cellular defense mechanisms and neurological function in developing fish.
Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.
Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene
Researchers demonstrated maternal transfer of polystyrene nanoplastics in zebrafish by feeding exposed females and detecting particles in yolk sacs, livers, and guts of offspring, finding that transferred nanoplastics reduced antioxidant enzyme activity and caused bradycardia in embryos without major effects on overall reproductive success.
Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure
Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.
Polystyrene nanoplastics aggravated ecotoxicological effects of polychlorinated biphenyls in on zebrafish (Danio rerio) embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics combined with PCBs (polychlorinated biphenyls, banned industrial chemicals that persist in the environment) and found that nanoplastics significantly worsened PCB toxicity — amplifying damage to bone and heart development and suppressing the genes that normally help detoxify harmful chemicals. The nanoplastics also accumulated in the liver, intestine, and gills of zebrafish rather than being excreted, raising serious concerns about the ecological risks of rising nanoplastic levels in aquatic environments.
Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
Researchers exposed zebrafish to environmentally realistic levels of polystyrene nanoplastics and found they caused both brain and reproductive damage. The nanoplastics disrupted neurotransmitter signaling and impaired the hormonal pathway connecting the brain to reproductive organs, with different effects in males and females. These findings suggest that even low-level nanoplastic exposure could affect both brain function and fertility in aquatic life that humans may consume.
Effects of nanoplastics on zebrafish embryo-larval stages: A case study with polystyrene (PS) and polymethylmethacrylate (PMMA) particles
Researchers assessed the effects of polystyrene and polymethylmethacrylate nanoparticles on zebrafish embryos and larvae over 96 hours. The study found that these nanoplastics affected biochemical endpoints related to neurotransmission, antioxidant status, oxidative damage, and energy metabolism, with effects varying by plastic type. Evidence suggests that smaller plastic particles may have increased bioavailability and reactivity compared to larger fragments.
Polystyrene nanoplastics induced size-dependent developmental and neurobehavioral toxicities in embryonic and juvenile zebrafish
Researchers exposed zebrafish embryos and juveniles to polystyrene nanoplastics of three different sizes and found that all sizes crossed into the brain, eyes, and other organs. Smaller particles tended to cause different types of damage than larger ones, including changes in brain development and behavior. This size-dependent toxicity is relevant to human health because we are exposed to a wide range of nanoplastic sizes through food and water.
Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos
Researchers studied the bioaccumulation of polystyrene nanoplastics in zebrafish embryos and their interaction with gold ions. They found that smaller nanoplastics readily penetrated the embryo's protective membrane and accumulated in lipid-rich regions, particularly the yolk. While nanoplastics alone caused only marginal toxic effects, their presence synergistically amplified the toxicity of gold ions through increased oxidative stress and inflammatory responses, suggesting that nanoplastics may worsen the harmful effects of co-occurring environmental contaminants.
Bioaccumulation of various nanoplastic particles in larval zebrafish (Danio rerio)
Researchers exposed larval zebrafish (Danio rerio) to 40-60 nm and 100 nm polystyrene nanoplastic particles using standard fish embryo toxicity and general behavioral toxicity assays from 6-120 hours post-fertilization, combining toxicity endpoints with fluorescence microscopy to confirm particle uptake and excretion. The study demonstrated nanoplastic accumulation within zebrafish larvae at tested concentrations, providing mechanistic insights into aquatic organism exposure dynamics for nanoplastics.
Nanoplastic Exposure Mediates Neurodevelopmental Toxicity by Activating the Oxidative Stress Response in Zebrafish (Danio rerio)
Exposure to 20-nanometer plastic particles caused developmental problems in zebrafish embryos, including shorter body length, heart defects, and lower survival rates. The nanoplastics specifically damaged the development of motor neurons and triggered oxidative stress, a harmful chemical imbalance in cells. These results suggest that very small plastic particles could interfere with early brain and nerve development.
The mechanism of polystyrene nanoplastics hepatotoxicity in zebrafish (Danio rerio)
This study investigated the hepatotoxic mechanisms of polystyrene nanoplastics in zebrafish (Danio rerio), finding that nanoplastics accumulating in the liver triggered oxidative stress and cellular injury pathways. The results highlight nanoplastics as a significant liver toxicant in aquatic vertebrates.
Embryotoxicity of polystyrene microplastics in zebrafish Danio rerio
Researchers exposed zebrafish embryos to polystyrene microplastics during early development and observed serious physical deformities, particularly in the spine, tail, and eyes, despite no increase in mortality. The exposed larvae also showed elevated expression of genes involved in oxidative stress defense and cellular detoxification. The findings suggest that microplastics can disrupt critical developmental stages in freshwater fish even when they do not directly cause death.
Effects of polystyrene nanoplastic size on zebrafish embryo development
Researchers exposed zebrafish embryos to polystyrene nanoplastics of four sizes and found only the smallest (30 nm) caused mortality and altered oxidative stress and apoptosis gene expression, while larger particles (100–450 nm) were ingested and accumulated in the digestive system without causing developmental malformations.
Adverse adult-onset and multigenerational effects in zebrafish (Danio rerio) developmentally exposed to polystyrene nanoplastics
Researchers raised zebrafish exposed to nanoplastics during early development through to adulthood and found lasting reproductive impairment, heritable hyperactivity in offspring, and molecular changes in male reproductive and brain tissue linked to neurodegenerative disease pathways and endocrine disruption, demonstrating that brief developmental nanoplastic exposure can cause multigenerational harm.
Special Distribution of Nanoplastics in the Central Nervous System of Zebrafish during Early Development
Researchers injected fluorescent nanoplastics into zebrafish embryos and found the particles became trapped in the brain, eyes, and spinal cord during early development and stayed there rather than moving to other organs. Although the nanoplastics did not embed directly in nerve cells, they still disrupted brain signaling and reduced larval movement, suggesting early-life nanoplastic exposure could interfere with nervous system development.
Evaluation of the infiltration of polystyrene nanobeads in zebrafish embryo tissues after short-term exposure and the related biochemical and behavioural effects
Researchers exposed zebrafish embryos to fluorescent polystyrene nanobeads and used confocal microscopy to confirm nanoplastic uptake beyond the gut — migrating into surrounding tissues — while biochemical markers revealed decreased cyclooxygenase activity, elevated superoxide dismutase, and altered swimming behavior, demonstrating tissue-infiltrating potential after only 48 hours of exposure.