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Special Distribution of Nanoplastics in the Central Nervous System of Zebrafish during Early Development
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Researchers injected fluorescent nanoplastics into zebrafish embryos and found the particles became trapped in the brain, eyes, and spinal cord during early development and stayed there rather than moving to other organs. Although the nanoplastics did not embed directly in nerve cells, they still disrupted brain signaling and reduced larval movement, suggesting early-life nanoplastic exposure could interfere with nervous system development.
There is growing concern about the distribution of nanoplastics (NPs) in the central nervous system (CNS), whereas intrusion is poorly understood. In this study, fluorescent-labeled polystyrene NPs (PS-NPs) were microinjected into different areas of zebrafish embryo to mimic different routes of exposure. PS-NPs were observed in the brain, eyes, and spinal cord through gametal exposure. It indicated that maternally derived PS-NPs were specially distributed in the CNS of zebrafish during early development. Importantly, these NPs were stranded in the CNS but not transferred to other organs during development. Furthermore, using neuron GFP-labeled transgenic zebrafish, colocalization between NPs and the neuron cells revealed that NPs were mostly enriched in the CNS surrounded but not the neurons. Even so, the intrusion of NPs into the CNS induced the significant upregulation of some neurotransmitter receptors, leading to an inhibited effect on the movement of zebrafish larvae. This work provides insights into understanding the intrusion and distribution of NPs in the CNS and the subsequent potential adverse effects.
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Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development
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Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.
Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)
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Researchers tracked the uptake and distribution of polystyrene nanoparticles in developing zebrafish and found that the particles accumulated in the yolk sac and then spread to the brain, liver, heart, and other organs. While the nanoparticles did not cause significant mortality or deformities, they did reduce heart rate and alter swimming behavior. The study suggests that nanoplastics can penetrate biological barriers and accumulate in multiple tissues during early development.
Micro- and Nanoplastics Exposure and Effects on Embryonic Development and Larval Behavior of Zebrafish
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Researchers exposed zebrafish embryos to nanoplastics for three to five days and measured developmental and behavioral endpoints, finding that plastic accumulation in early development slowed yolk consumption and body growth on day two and increased locomotion while reducing body length by day six — supporting persistent developmental disruption from nanoplastic exposure.
Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos
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Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.
Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
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Researchers developed a method using fluorescent microplastics to visually track the accumulation and distribution of plastic particles in zebrafish embryos and larvae. The technique revealed that microplastics accumulate in specific tissues during early development, with potential implications for aquatic organisms exposed in polluted waters.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.