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61,005 resultsShowing papers similar to Hypoxia is a key mechanism for regulating inflammation in ulcerative colitis
ClearA potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals
This review explored how plant-based compounds could be used to treat ulcerative colitis by targeting mitochondrial function. Researchers discussed how dysfunctional mitochondria generate excessive reactive oxygen species that drive intestinal inflammation. While focused on therapeutic approaches rather than microplastics directly, the study is relevant to understanding how environmental stressors that damage mitochondria may contribute to gut inflammation.
Impact of micro- and nanoplastics on gastrointestinal diseases: Recent advances
This review summarizes how micro- and nanoplastics can harm the digestive system by causing oxidative stress, inflammation, cell death, and disruption of gut bacteria. These connected pathways can damage the intestinal lining and may contribute to conditions like inflammatory bowel disease and colorectal cancer. The findings highlight the importance of understanding how everyday plastic exposure through food and water could affect gut health over time.
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer.
This review synthesizes evidence linking ingested micro- and nano-plastics to inflammatory bowel disease and colorectal cancer risk, proposing that microplastics act as a hidden driver of gut inflammation in vulnerable populations. The authors argue that intestinal accumulation of microplastics triggers immune and oxidative stress pathways that contribute to disease progression.
Influence of Microplastics on Manifestations of Experimental Chronic Colitis
Researchers studied whether consuming microplastics worsens chronic colon inflammation in mice. While microplastics alone did not cause visible damage to healthy intestines, they significantly increased the severity of colitis symptoms, including more ulcers and greater inflammatory cell infiltration, in mice with pre-existing colon inflammation. The findings suggest that microplastic exposure may be particularly concerning for individuals who already have inflammatory bowel conditions.
The role of microplastics in the pathogenesis of inflammatory bowel diseases
This review of existing research found that tiny plastic particles we eat and drink may contribute to inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The plastic bits can damage the gut lining, cause inflammation, and disrupt the healthy bacteria in our intestines. While more research is needed to confirm the connection, this suggests that reducing plastic pollution could be important for protecting our digestive health.
Influence of Microplastics on Morphological Manifestations of Experimental Acute Colitis
Researchers fed polystyrene microplastics to mice for six weeks and found that healthy mice developed changes in their colon lining, including altered mucus composition and immune cell populations. When mice with experimentally induced colitis also consumed microplastics, their intestinal inflammation was significantly more severe. The study suggests that microplastic exposure may worsen inflammatory bowel conditions.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review of 30 in vitro studies found that microplastics and nanoplastics cause size- and concentration-dependent damage to human gastrointestinal cells, including increased oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Smaller particles consistently showed greater cellular uptake and biological effects, though chronic low-dose exposure generally produced minimal impacts.
Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer
This review explores how microplastics that accumulate in the human body may trigger long-lasting inflammation, which is a known driver of cancer development. The authors describe how microplastics can disrupt the gut microbiome, activate immune responses, and alter signaling pathways in ways that could promote tumor growth over time.
The hidden poison - microplastic : Inflammatory catalyst of cancer development
This review discusses how microplastics act as inflammatory agents within biological tissues, summarizing evidence that ingested and inhaled microplastics can trigger oxidative stress, immune responses, and chronic inflammation in humans and animals.
The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway
This review maps out how micro and nanoplastics damage the digestive system, identifying oxidative stress as the initial trigger that leads to inflammation, cell death, disrupted gut bacteria, and metabolic disorders. The authors use an adverse outcome pathway framework to connect molecular-level damage to broader health consequences. The findings suggest that ongoing microplastic exposure through food and water could contribute to digestive health problems.
Microplastic effects on mouse colon in normal and colitis conditions: A literature review
This literature review examined studies on how microplastic exposure affects the mouse colon under both normal and inflammatory conditions. Evidence indicates that microplastics may contribute to intestinal inflammation and could worsen existing colitis. The review highlights the need for further research to better understand how microplastic ingestion may influence gut health in humans.
Microplastics and Colorectal Cancer: Presence in Human Colorectal Tissues and Associations with Tumor Biology- A Systematic Review
This review of 13 studies found that tiny plastic particles called microplastics are present in human colon tissues, with higher amounts found in cancerous tumors compared to healthy tissue. The research suggests these plastic particles may contribute to colon cancer development by causing inflammation and creating conditions that help tumors grow. While more research is needed to prove a direct cause-and-effect relationship, this highlights growing concerns about how plastic pollution in our environment and food supply might affect human health.
Multiomics RevealsNonphagocytosable MicroplasticsInduce Colon Inflammatory Injury via Bile Acid-Gut Microbiota Interactionsand Barrier Dysfunction
Mice were given long-term oral exposure to 10 µm polystyrene microplastics (too large for cellular uptake) and colonic inflammatory injury was assessed using multi-omics. Non-phagocytosable microplastics disrupted the colonic redox balance, elevated the Th17/Treg ratio, and caused colitis through bile acid-gut microbiota interactions and intestinal barrier dysfunction.
A Comprehensive Narrative Review of Potential Gastrointestinal Adverse Effects From Micro(nano) Plastic Exposure
This narrative review synthesizes evidence on gastrointestinal adverse effects of micro- and nanoplastic exposure, examining how these particles interact with gut microbiota, mucosal barriers, and immune tissue to contribute to inflammatory bowel disease, liver disease, and colorectal cancer risk.
Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers found that polystyrene micro- and nanoplastics aggravated colitis symptoms in a mouse model, increasing gut permeability, inflammatory cytokine levels, and tissue damage compared to controls. The study provides mechanistic evidence linking microplastic exposure to worsening of inflammatory bowel conditions.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Role of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review
This systematic review found that mitochondrial dysfunction plays a significant role in inflammatory bowel diseases through multiple mechanisms, including disrupted energy production, impaired mucosal repair, altered gut microbiota signaling, and weakened intestinal barrier integrity. The findings are relevant to microplastic research because plastic particle exposure has been shown to cause mitochondrial damage in gut tissues.
Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review
This systematic review examines the potential link between microplastics and nanoplastics and colorectal cancer. The research highlights how these tiny particles may contribute to cancer development through mechanisms like chronic inflammation and cellular damage in the gut. While more studies are needed, the findings raise important questions about the long-term consequences of ingesting plastic particles.
Microplastic accumulation in fibrotic intestinal tissue and mesenteric adipose tissue in Crohn’s disease patients
Researchers found microplastic accumulation in intestinal tissue and surrounding fat from Crohn's disease patients, with higher concentrations in areas with more severe scarring and inflammation. Twelve types of microplastics were identified, and frequent invasive medical procedures appeared to worsen the buildup. This is the first study showing that microplastics can penetrate the intestinal barrier in Crohn's patients, raising questions about whether plastic exposure could contribute to disease progression.
From Exposure to Oncogenesis: the Role of Microplastics and Associated Pollutants in Cancer - a Literature Review
This literature review examined the growing evidence linking microplastic exposure to cancer development. Microplastics have been found in human lung, liver, and colon tissue, and research suggests they may promote cancer through chronic inflammation, oxidative stress, and by carrying known carcinogens like heavy metals and persistent organic pollutants into the body.
Mitigating microplastic-induced organ Damage: Mechanistic insights from the microplastic-macrophage axes
This review is the first comprehensive examination of how microplastics interact with macrophages, the immune cells responsible for engulfing and removing foreign particles from the body. When macrophages absorb microplastics, the resulting oxidative stress disrupts their normal function, leading to inflammation and organ damage, with gut bacteria potentially playing a role in this harmful process.
A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids
Researchers compared microplastic effects across colon cells, mouse models, and colon organoids, finding that microplastic ingestion can induce tissue damage and alter cellular function in the digestive system, with organoids providing a valuable intermediate testing platform.
Micro(nano)plastics in food system: potential health impacts on human intestinal system.
This review assessed how micro(nano)plastics in the human food system reach the intestine and accumulate in the gut, summarizing evidence that they can alter intestinal barrier function, trigger inflammation, and disrupt the gut microbiome, with implications for long-term digestive health.
Micro-sized polyethylene particles affect cell viability and oxidative stress responses in human colorectal adenocarcinoma Caco-2 and HT-29 cells
Researchers tested the effects of micro-sized polyethylene particles on two types of human colon cancer cells commonly used in gut research. The microplastics reduced cell survival and triggered oxidative stress, which is a type of cellular damage caused by an imbalance of harmful molecules. This study provides evidence that microplastics reaching the human gut through food and water could damage intestinal cells, though more research is needed at real-world exposure levels.