Papers

61,005 results
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Article Tier 2

Exposure to polypropylene microplastics via diet and water induces oxidative stress in Cyprinus carpio

Researchers fed carp fish polypropylene microplastics through both food and water and found that exposure caused oxidative stress in the liver, gills, and intestines. The damage was dose-dependent, with higher microplastic concentrations causing more harm to the fish's antioxidant defense systems. Since carp is a widely consumed fish, these findings raise questions about whether microplastics in aquaculture could affect the safety of fish as human food.

2023 Aquatic Toxicology 76 citations
Article Tier 2

Size-dependent effects of microplastic on uptake, immune system, related gene expression and histopathology of goldfish (Carassius auratus)

Researchers exposed goldfish to two sizes of polystyrene microplastics at environmentally relevant concentrations for 28 days. The study found that microplastics accumulated in gill, liver, and intestine tissues, causing damage that worsened with smaller particle size and higher doses. The results indicate that microplastics trigger oxidative stress and immune responses in fish, with smaller particles posing greater health risks.

2021 Chemosphere 176 citations
Article Tier 2

Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var. larvae

Researchers exposed carp larvae to polyvinyl chloride microplastics in their diet for 30 and 60 days at various concentrations. The microplastics significantly inhibited growth and weight gain while causing oxidative stress, altered antioxidant enzyme activities, and changes in gene expression in the liver. Histological examination revealed tissue damage including vacuolation in the liver under higher exposure concentrations.

2020 The Science of The Total Environment 291 citations
Article Tier 2

Subacute toxic effects of polyvinyl chloride microplastics (PVC-MPs) in juvenile common carp, Cyprinus carpio (Pisces: Cyprinidae)

Juvenile common carp exposed to polyvinyl chloride microplastics showed dose-dependent toxic effects including tissue damage, oxidative stress, and altered biochemical markers over a subacute exposure period. The results indicate that PVC microplastics are harmful to freshwater fish at ecologically relevant concentrations.

2022 SHILAP Revista de lepidopterología 10 citations
Article Tier 2

Dietary exposure to polyvinyl chloride microparticles induced oxidative stress and hepatic damage in Clarias gariepinus (Burchell, 1822)

Catfish (Clarias gariepinus) fed PVC microparticle-spiked diets at three inclusion levels for 45 days showed dose-dependent liver damage, elevated antioxidant enzyme activity, and altered serum biochemistry, indicating that dietary PVC microplastic ingestion causes measurable hepatotoxicity.

2020 Environmental Science and Pollution Research 99 citations
Article Tier 2

Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics

Researchers exposed juvenile Nile Tilapia to different concentrations of microplastics for 15 days followed by a recovery period. The study found dose-dependent increases in oxidative stress markers, DNA fragmentation, and altered protein patterns in fish exposed to microplastics. Evidence indicates that while fish exposed to the lowest concentration recovered after the treatment ended, higher doses caused more persistent damage.

2020 Environmental Science and Pollution Research 192 citations
Article Tier 2

Microplastic exposure causes organ damage in Puntius sophore

Researchers sampled a freshwater ecosystem in Tamil Nadu, India, and exposed the local fish Puntius sophore to collected microplastics at sub-lethal concentrations, then assessed organ damage. Microplastic exposure caused histological damage in gills, liver, and kidney of this freshwater sentinel species, with oxidative stress biomarkers elevated in all three organs.

2025 Environmental Monitoring and Assessment
Article Tier 2

Toxic effects of microplastic (polyethylene) exposure: Bioaccumulation, hematological parameters and antioxidant responses in crucian carp, Carassius carassius

Researchers exposed crucian carp to polyethylene microplastics at various concentrations and found that the particles accumulated in tissues including gills, gut, and liver. The microplastics altered blood cell counts and disrupted the fish's antioxidant defense system in a dose-dependent manner. The study suggests that even common polyethylene microplastics can cause measurable biological harm in freshwater fish.

2023 Chemosphere 35 citations
Article Tier 2

Ingestion of Polyvinylchloride Powder Particles Induces Oxidative Stress and Hepatic Histopathological Changes in Oreochromis niloticus (Nile Tilapia)—A Preliminary Study

Researchers found that oral exposure to PVC microplastic powder induced oxidative stress and liver histopathological changes in Nile tilapia, with altered water quality parameters and tissue damage indicating significant toxicological effects from ingested plastic particles.

2023 Sustainability 8 citations
Article Tier 2

Effects of microfiber and bead microplastic exposure in the goldfish Carassius auratus: Bioaccumulation, antioxidant responses, and cell damage

Researchers exposed goldfish to two types of microplastics, fibers and beads, and found that both caused oxidative stress in the liver and kidney, with fiber-type microplastics generally producing stronger effects. The microplastics accumulated in fish tissues and triggered changes in antioxidant gene expression and cell damage over the five-day exposure period. The findings suggest that the shape of microplastics matters for their biological impact, with fibers potentially being more harmful than beads.

2023 Aquatic Toxicology 25 citations
Article Tier 2

Histopathological Alterations in Gills, Liver and Kidneys of Goldfish (Carassius auratus) Exposed to Polystyrene Microplastics

Goldfish chronically exposed to 1 μm polystyrene microplastics at 1.53 mg/L for 28 days developed histopathological damage in gills, kidneys, and liver, including epithelial lifting, glomerular atrophy, and hepatocellular necrosis, demonstrating organ-level toxicity from chronic PS-MP exposure.

2025 UTTAR PRADESH JOURNAL OF ZOOLOGY
Article Tier 2

Effects of Polystyrene Nanoplastics on Oxidative Stress, Blood Biochemistry, and Digestive Enzyme Activity in Goldfish (Carassius auratus)

Goldfish exposed to polystyrene nanoplastics in their diet for 21 days showed significant oxidative stress, disrupted blood chemistry, and reduced digestive enzyme activity, with effects worsening at higher doses. The smallest nanoplastics caused the most damage to the fishes' antioxidant defense systems and overall health. These findings add to the evidence that nanoplastics in aquatic environments can harm fish health in ways that may affect the safety of fish consumed by humans.

2025 Toxics 8 citations
Article Tier 2

A dosage-effect assessment of acute toxicology tests of microplastic exposure in filter-feeding fish

Researchers assessed the dose-dependent effects of polystyrene microplastics on silver carp, a filter-feeding fish, during a 48-hour exposure and recovery period. Low concentrations induced oxidative stress and gene upregulation in the intestine, with the fish able to recover after exposure ended. However, high concentrations caused significant gill and intestinal damage that persisted even after the microplastics were removed.

2021 Fish & Shellfish Immunology 57 citations
Article Tier 2

Toxic effects of polyethylene microplastics on transcriptional changes, biochemical response, and oxidative stress in common carp (Cyprinus carpio)

Researchers exposed common carp to varying concentrations of polyethylene microplastics and assessed biochemical, oxidative, and gene expression changes. The study found that microplastic exposure caused significant oxidative stress, altered liver enzyme activity, and modified the expression of stress-related genes in a dose-dependent manner.

2022 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 72 citations
Article Tier 2

Exposure of Cyprinus carpio var. larvae to PVC microplastics reveals significant immunological alterations and irreversible histological organ damage

Researchers conducted a 60-day feeding experiment exposing carp larvae to PVC microplastics at varying concentrations and found significant immune system disruption and organ damage. The microplastics caused liver vacuolation, intestinal villi damage, spleen inflammation, and kidney degeneration, along with elevated inflammatory markers and reactive oxygen species. The findings indicate that chronic dietary exposure to PVC microplastics can cause serious and potentially irreversible harm to freshwater fish immune function.

2022 Ecotoxicology and Environmental Safety 55 citations
Article Tier 2

Effects of Polystyrene Microplastic Exposure on Liver Cell Damage, Oxidative Stress, and Gene Expression in Juvenile Crucian Carp (Carassius auratus)

Researchers exposed young crucian carp to polystyrene microplastics at different concentrations and found dose-dependent liver damage, with higher concentrations causing more severe tissue injury and weaker antioxidant defenses. The microplastics disrupted genes involved in detoxification and stress response in liver cells. Since crucian carp is a commonly consumed freshwater fish, these findings raise questions about whether microplastic-contaminated fish could affect the health of people who eat them.

2025 Toxics 8 citations
Article Tier 2

Dietary administration of PVC and PE microplastics produces histological damage, oxidative stress and immunoregulation in European sea bass (Dicentrarchus labrax L.)

Researchers fed European sea bass diets containing PVC and polyethylene microplastics for three weeks and examined the effects on their organs and immune systems. They found significant tissue damage in the liver and intestine, along with signs of oxidative stress and altered immune function. The study suggests that even short-to-medium-term microplastic ingestion can compromise fish health, with longer exposures potentially leading to irreversible organ damage.

2019 Fish & Shellfish Immunology 244 citations
Article Tier 2

Microplastics Induce Structural Color Deterioration in Fish Poecilia reticulata Mediated by Oxidative Stress

Researchers exposed guppy fish to environmentally relevant concentrations of microplastics and nanoplastics, finding that 160 µg/L microplastics significantly reduced growth and impaired structural blue coloration by disrupting skin oxidative stress markers. Nanoplastics caused more severe gut lipid peroxidation, showing that plastic type matters for biological impact.

2025 Fishes
Article Tier 2

Integrated response of growth, antioxidant defense and isotopic composition to microplastics in juvenile guppy (Poecilia reticulata)

Guppy fish exposed to polystyrene microplastics at two concentrations for 28 days showed higher accumulation in gills than other tissues, reduced growth at high concentration, elevated oxidative stress, and shifts in stable isotope ratios indicating altered nutrient assimilation.

2020 Journal of Hazardous Materials 110 citations
Article Tier 2

Polylactic Acid-Based Microplastic Particles Induced Oxidative Damage in Brain and Gills of Goldfish Carassius auratus

Researchers exposed goldfish to particles from biodegradable polylactic acid cups and shopping bags, as well as conventional polyamide plastic, for 96 hours. They found that the PLA cup particles caused significant oxidative damage in the fish's brain and gill tissues, while the bag and conventional plastic particles did not. The study raises important questions about whether bioplastic alternatives may pose their own environmental risks to aquatic life.

2023 Water 15 citations
Article Tier 2

Chronic nanoplastic exposure induced oxidative and immune stress in medaka gonad

Researchers exposed medaka fish to nanoplastics at varying concentrations over an extended period and found significant oxidative stress and immune disruption in their reproductive organs. Higher concentrations led to tissue damage in the gonads and altered expression of genes related to inflammation and antioxidant defense. The study suggests that chronic, low-level nanoplastic exposure may affect fish reproductive health over time.

2023 The Science of The Total Environment 49 citations
Article Tier 2

Toxicity and Functional Tissue Responses of Two Freshwater Fish after Exposure to Polystyrene Microplastics

Researchers exposed zebrafish and perch to polystyrene microplastics for 21 days and assessed tissue-level damage using a battery of biomarkers. They found that the microplastics caused oxidative stress, DNA damage, and activated cell death pathways in both gill and liver tissues. The study suggests that gills are more sensitive to microplastic exposure than liver tissue for most measured parameters, with DNA damage being the most responsive biomarker overall.

2021 Toxics 79 citations
Article Tier 2

Toxic effects of microplastics on freshwater fish (Channa argus): mechanisms of inflammation, apoptosis, and autophagy

Freshwater snakehead fish exposed to polystyrene microplastics for four weeks developed inflammation, cell death, and tissue damage in their liver, intestines, kidneys, and gills. The damage worsened with higher microplastic concentrations and involved disruption of the fish's antioxidant defenses and immune system. Since snakehead is a commonly consumed fish in Asia, these findings raise questions about whether microplastics in aquaculture environments could affect the safety of fish as human food.

2025 Aquatic Toxicology 8 citations
Article Tier 2

The effects of exposure to microplastics on grass carp (Ctenopharyngodon idella) at the physiological, biochemical, and transcriptomic levels

Researchers exposed grass carp to microplastics at two concentrations for 21 days and observed liver damage, inhibited growth, and increased oxidative stress. Transcriptome analysis revealed over 1,500 differentially expressed genes related to immune response, metabolism, and cellular stress pathways. The study suggests that microplastic exposure can trigger broad physiological and molecular disruptions in freshwater fish.

2021 Chemosphere 54 citations