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61,005 resultsShowing papers similar to Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
ClearMaternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics and studied the effects on their offspring's brain development. The study found that maternal nanoplastic exposure affected developmental milestones and brain structure in the young mice. The findings suggest that nanoplastic exposure during pregnancy may pose risks to fetal brain development, though more research is needed to understand the implications for humans.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
When pregnant mice were exposed to polystyrene nanoplastics, their offspring showed abnormal brain development including changes in neural stem cell function, altered brain structure, and cognitive problems. The effects were gender-specific, with some deficits appearing more strongly in one sex. This study raises concerns that nanoplastic exposure during pregnancy could increase the risk of neurodevelopmental problems in children.
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring
When pregnant and nursing rats were exposed to polystyrene nanoplastics, their offspring showed thinner brain cortexes, disrupted neurotransmitter levels, damaged connections between brain cells, and problems with anxiety and spatial memory. This study suggests that maternal exposure to nanoplastics during pregnancy and breastfeeding could affect brain development in offspring.
Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure
Researchers exposed parent mice to polystyrene nanoplastics before and during pregnancy and found that offspring exhibited skeletal and visceral malformations, impaired neonatal reflexes, learning deficits, and structural brain changes — including reduced hippocampal neurons — demonstrating transgenerational neurodevelopmental harm from nanoplastic exposure.
Intergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe-gut-brain axis
Researchers found that mother mice exposed to polystyrene nanoplastics during pregnancy and nursing passed neurological harm to their offspring, with the babies showing brain inflammation, disrupted dopamine and serotonin signaling, and gut microbiome imbalances — suggesting that nanoplastic exposure before birth can damage the developing brain through the gut-brain connection.
Effects of Polystyrene Nanoplastics on the Biology of Human Neural Stem Cells and Human Cerebral Organoids.
This study investigated the effects of polystyrene nanoplastics on human neural stem cells and human cerebral organoids, examining whether nanoplastics that have been shown to cross the blood-brain barrier and placenta can disrupt normal brain development. Given the lack of prior research on nanoplastic effects on the developing brain, the findings carry significant implications for understanding neurodevelopmental risks from early-life plastic exposure.
[Effects of nanopolystyrene nanoplastic exposure on the development and neurotoxicity of fetal rats during gestation].
Researchers found that gestational exposure to polystyrene nanoplastics in rats caused dose-dependent reductions in fetal body weight, body length, and brain development, with smaller 25 nm particles producing more pronounced neurotoxic effects than 50 nm particles.
Nanoplastic toxicology following gestational and lactational exposure
This review examines evidence from animal studies showing that polystyrene nanoplastics can cross the placental barrier during pregnancy, accumulate in maternal and offspring organs, and cause widespread toxicity. Reported effects in offspring include reproductive and endocrine disruption, neurodevelopmental abnormalities, cardiovascular damage, and metabolic disorders, with the severity of effects influenced by particle size, dose, and timing of exposure.
Molecular effects of polystyrene nanoplastics on human neural stem cells
Researchers exposed human brain stem cells to tiny polystyrene nanoplastics and found they caused oxidative stress, DNA damage, inflammation, and cell death. These findings suggest that nanoplastics could potentially harm brain development if they reach neural tissue, though more research is needed to understand real-world exposure levels.
Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice
Researchers exposed pregnant mice to polystyrene micro and nanoplastics and found that exposure caused fetal growth restriction and placental abnormalities. The study observed that plastic particles accumulated in placental tissue and disrupted normal placental function. These findings raise concern that maternal exposure to plastic particles during pregnancy may interfere with fetal development.
Effects of orally administered polystyrene nanoplastics on reproduction and development in rodents
This study examined the reproductive and developmental effects of orally administered polystyrene nanoplastics in an animal model, finding that NP ingestion impaired fertility metrics and offspring development, contributing to growing evidence of nanoplastic reproductive toxicity.
Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice
Researchers exposed pregnant mice to polystyrene nanoplastics through drinking water and found that higher concentrations led to significantly reduced fetal weight. The nanoplastics caused abnormal cell structures in the placenta and disrupted metabolic processes in both placental tissue and fetal livers. The study suggests that maternal nanoplastic exposure during pregnancy can cross the placental barrier and interfere with normal fetal growth and metabolism.
Maternal polystyrene nanoplastics exposure during pregnancy induces obesity development in adult offspring through disrupting lipid homeostasis
Researchers found that maternal inhalation exposure to polystyrene nanoplastics during pregnancy induced obesity development in adult offspring of mice, suggesting in utero exposure to airborne nanoplastics programs metabolic dysfunction. The study linked prenatal nanoplastic exposure to increased adiposity and metabolic changes persisting into adulthood.
From mothers to offspring: Polystyrene nanoplastics create a hidden toxic legacy via mitochondrial dysfunction
Researchers exposed female zebrafish to polystyrene nanoplastics before mating with unexposed males and found that maternal exposure at 100 μg/L reduced offspring hatching success and caused developmental defects in the F1 generation raised in clean water, demonstrating transgenerational toxicity via mitochondrial dysfunction.
Maternal exposure to polystyrene nanoplastics alters fetal brain metabolism in mice
When pregnant mice drank water containing polystyrene nanoplastics at low concentrations, their unborn pups showed significant changes in brain chemistry, including a 40% drop in GABA (a key brain chemical) and a 30% drop in glucose levels. These metabolic disruptions in the fetal brain could help explain the structural brain changes previously seen in pups born to nanoplastic-exposed mothers. This study raises concerns that nanoplastic exposure during pregnancy could affect fetal brain development in humans.
Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.
Maternal exposure to polystyrene microplastics impairs social behavior in mouse offspring with a potential neurotoxicity
When pregnant mice were exposed to polystyrene microplastics, their offspring showed impaired social behavior even though the plastics did not reach the brain directly. The microplastics accumulated in the mothers' digestive organs and caused changes in brain cell growth and survival in isolated neurons. This study suggests that microplastic exposure during pregnancy could affect brain development and social behavior in offspring through indirect mechanisms.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers found that nanoscale polystyrene particles inhaled by pregnant mice were able to cross into the placenta and deposit in fetal tissues. The findings raise concerns about potential developmental risks from airborne nanoplastic exposure during pregnancy.
Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics throughout mating, pregnancy, and nursing, then examined the ovaries of their female offspring. They found that maternal nanoplastic exposure significantly reduced ovarian weight and follicle numbers in the offspring and lowered the expression of key antioxidant genes. The study suggests that nanoplastic exposure during pregnancy may pose risks to the reproductive development of female offspring.
Polystyrene nanoplastics exposure caused defective neural tube morphogenesis through caveolae-mediated endocytosis and faulty apoptosis
This study found that polystyrene nanoplastics caused abnormal neural tube formation in early embryonic development by being taken up through a specific cellular pathway and triggering defective cell death. The findings suggest nanoplastics could potentially interfere with fetal brain development, raising serious concerns about exposure during pregnancy.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers exposed pregnant mice to nanoscale polystyrene particles through inhalation and tracked where the particles traveled. They found that the nanoplastics crossed from the lungs into the bloodstream and accumulated in both placental and fetal tissues, confirming that inhaled plastic nanoparticles can reach developing offspring during pregnancy.
Polystyrene micro- and nanoplastics cause placental dysfunction in mice
Pregnant mice exposed to polystyrene micro- and nanoplastics in drinking water showed signs of placental dysfunction, with nanoplastics causing more severe effects than microplastics. Both sizes triggered a brain-sparing response in fetuses, where blood flow is redirected to protect the brain from low oxygen, a sign of fetal distress. These findings suggest that nanoplastic exposure during pregnancy could disrupt normal placental function and potentially affect fetal brain development.
Maternal exposure to nanopolystyrene induces neurotoxicity in offspring through P53-mediated ferritinophagy and ferroptosis in the rat hippocampus
When pregnant and nursing rats were fed nanoplastics, their offspring showed impaired learning and memory due to a specific type of cell death called ferroptosis in the brain's hippocampus. The nanoplastics triggered a chain reaction involving oxidative stress and iron buildup that damaged developing brain cells, suggesting that maternal exposure to nanoplastics during pregnancy and breastfeeding could harm offspring brain development.
The potential toxicity of polystyrene nanoplastics to human trophoblasts in vitro
Researchers used human trophoblast cells to evaluate the potential toxicity of 100-nanometer polystyrene nanoplastics on placental function. The study found that nanoplastic exposure affected trophoblast cell viability and function at certain concentrations, suggesting potential implications for understanding nanoplastic effects during pregnancy.