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61,005 resultsShowing papers similar to No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period
ClearToxicities Demonstrated in Dams and Neonates following Intragastric Intubation of Polyethylene Microplastics to Pregnant Mice
Researchers found that intragastric administration of polyethylene microplastics to pregnant mice caused oxidative stress, inflammation, and reproductive toxicity in dams, with evidence of transplacental transfer producing developmental abnormalities in neonates.
Evaluation of Liver Toxicity of Neonates Following Intragastric Administration or Intratracheal Instillation of Polyethylene Microplatics to Pregnant Mice
Researchers found that pregnant mice exposed to polyethylene microplastics via oral ingestion or inhalation passed particles to offspring, causing oxidative stress and inflammation in neonatal livers, with inhalation exposure producing more severe effects than oral exposure.
Correction to: No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period
This is a published correction to an earlier study that found no significant toxicity from polyethylene microplastics in newborn mice exposed through their mothers. The correction addresses a methodological detail in the original paper. The underlying finding — that intratracheal exposure to polyethylene microplastics during pregnancy and nursing caused no prominent toxicity — remains unchanged.
Investigation of Pulmonary Inflammatory Responses Following Intratracheal instillation of and Inhalation exposure to Polypropylene Microplastics
Researchers conducted short-term pulmonary toxicity studies by exposing mice to polypropylene microplastics via intratracheal instillation and inhalation, finding dose-dependent inflammatory responses in lung tissue that confirm inhalation as a significant exposure route of concern.
Identification of micro- and nanoplastic particles in postnatal sprague-dawley rat offspring after maternal inhalation exposure throughout gestation
Pregnant rats that inhaled micro- and nanoplastic particles throughout gestation passed them to their offspring, with plastic particles detected in pup tissues after birth. This is one of the first studies to show that inhaled microplastics can cross the placental barrier during pregnancy and persist in offspring, raising concerns about prenatal exposure from airborne plastic pollution.
In vivo toxicity assessment of microplastics in Balb/C mice : study of inhalation exposure and its inflammatory effects
Researchers examined the in vivo toxicity of inhaled microplastics in Balb/C mice, studying pulmonary inflammation, oxidative stress, and systemic effects following repeated inhalation exposure. The study found dose-dependent lung inflammation and evidence of particle translocation to other organs.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers exposed pregnant mice to nanoscale polystyrene particles through inhalation and tracked where the particles traveled. They found that the nanoplastics crossed from the lungs into the bloodstream and accumulated in both placental and fetal tissues, confirming that inhaled plastic nanoparticles can reach developing offspring during pregnancy.
Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation
Researchers administered polyethylene microplastics to mice by oral gavage for 90 days and observed significant effects including reduced body weight gain, increased neutrophil counts, and immune system changes. Microplastic-like material persisted in stomach tissue, and immune markers were altered in treated animals. A follow-up reproductive study found that microplastic exposure affected the number of live births, sex ratio of pups, and offspring immune cell populations, suggesting the need for further reproductive toxicity testing.
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice
Researchers tested the lung toxicity of three common plastic types -- polypropylene, polystyrene, and polyethylene -- in mice by exposing them to microplastic fragments. The study assessed how these inhaled microplastic particles from everyday plastics affect lung health, which is relevant since humans regularly breathe in airborne microplastics.
Immunodysregulatory potentials of polyethylene or polytetrafluorethylene microplastics to mice subacutely exposed via intragastric intubation
Researchers found that subacute oral exposure to polyethylene and polytetrafluoroethylene microplastics caused immune dysregulation in mice, with effects varying by particle size and polymer type, demonstrating that ingested microplastics can disrupt immune function.
Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy
Nanopolystyrene particles inhaled by pregnant mice during late pregnancy crossed into the bloodstream and deposited in fetal tissues. This finding raises concern that airborne nanoplastics could pose a risk to fetal development, especially given growing human exposure to plastic particles in indoor and outdoor air.
Micro- and nanoplastic inhalation during pregnancy: Impacts on uteroplacental function and offspring health
This review examined evidence that inhaled micro- and nanoplastics during pregnancy accumulate in placental and fetal tissues, impair uteroplacental blood flow and immune function, and are associated with adverse developmental outcomes in offspring, identifying inhalation as a critical but understudied exposure route.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers found that nanoscale polystyrene particles inhaled by pregnant mice were able to cross into the placenta and deposit in fetal tissues. The findings raise concerns about potential developmental risks from airborne nanoplastic exposure during pregnancy.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
This animal study found that nanopolystyrene particles inhaled by pregnant mice during late pregnancy were transferred across the placenta and deposited in fetal tissues. The findings provide experimental evidence that airborne nanoplastics can reach unborn fetuses, raising serious concerns about developmental exposure from breathing indoor or outdoor air containing plastic particles.
Investigation of pulmonary inflammatory responses following intratracheal instillation of and inhalation exposure to polypropylene microplastics
Rats exposed to polypropylene microplastics through both inhalation and direct lung delivery developed inflammatory responses in their lungs, including increased immune cells and tissue changes. Even at relatively low concentrations, the microplastics triggered pulmonary inflammation, supporting concerns that breathing in airborne microplastics could contribute to respiratory health problems in humans.
The Impact of Maternal Nanoplastic and Microplastic Particle Exposure on Mammal’s Offspring
This review summarizes research on how a mother's exposure to nanoplastics and microplastics during pregnancy can affect her developing baby. Studies show that these tiny plastic particles can cross the placenta and reach the fetus, potentially harming brain development, the reproductive system, metabolism, and the immune system of offspring. The review calls for more research using realistic exposure levels to better understand the risks of prenatal microplastic exposure to human babies.
Maternal ingestion of polyethylene microplastics results in reduced antiviral responses by dysregulating the immune system in their progeny
Researchers found that mice exposed to polyethylene microplastics during pregnancy transferred particles to offspring, and those offspring showed impaired antiviral immune responses. The findings suggest that maternal microplastic exposure can programme immune dysfunction in the next generation through disruption of developing immune systems.
Oral Exposure to Nylon-11 and Polystyrene Nanoplastics During Early-Life in Rats
Researchers exposed rat pups to nylon and polystyrene nanoplastics during early life to assess potential developmental effects. They found that while the nanoplastics did not cause overt toxicity at the doses tested, the particles did reach various organs and some subtle biological changes were observed. The study highlights the need for more research on how nanoplastic exposure during critical growth periods may affect long-term health.
Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice
Researchers fed mice two different sizes of polypropylene microplastics and found no significant toxic effects in standard toxicological assessments, including body weight, organ weight, and tissue examination. They established that the no-observed-adverse-effect level was at or above 2,000 milligrams per kilogram of body weight. Using fluorescently labeled particles, the team tracked the distribution of microplastics in real time, finding that the particles spread to multiple organs including the brain.
In Vivo Toxicity and Pharmacokinetics of Polytetrafluoroethylene Microplastics in ICR Mice
Researchers investigated the in vivo toxicity and pharmacokinetics of polytetrafluoroethylene (PTFE) microplastics in mice, finding that these particles accumulated in organs and caused dose-dependent inflammatory responses and oxidative stress.
Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice
Researchers exposed pregnant mice to polystyrene micro and nanoplastics and found that exposure caused fetal growth restriction and placental abnormalities. The study observed that plastic particles accumulated in placental tissue and disrupted normal placental function. These findings raise concern that maternal exposure to plastic particles during pregnancy may interfere with fetal development.
Gestational exposure to polystyrene microplastics incurred placental damage in mice: Insights into metabolic and gene expression disorders
This mouse study found that when pregnant mice were exposed to tiny polystyrene microplastics (0.1 micrometers), the particles crossed the placenta and reached fetal livers and brains, causing placental damage and impaired fetal development. Larger microplastics (5 micrometers) were less able to cross the placenta, suggesting that the smallest plastic particles pose the greatest risk during pregnancy.
Pulmonary toxicity of polymethyl methacrylate nanoplastics via intratracheal intubation in mice
Researchers exposed mice to polymethyl methacrylate nanoplastics through inhalation over 28 days to study their lung effects. The exposed mice experienced weight loss, nanoplastic accumulation in the lungs, increased inflammatory cell counts, and elevated inflammatory cytokines. The findings demonstrate that inhaling these common nanoplastics can induce lung inflammation, tissue damage, and changes in protein and RNA expression.
Pulmonary Toxicity of Polymethyl methacrylate nanoplastics via Intratracheal Intubation in Mice
Researchers administered polymethyl methacrylate (PMMA) nanoplastics directly into mouse lungs via intratracheal intubation and assessed pulmonary toxicity over time. PMMA NPs caused inflammatory cell recruitment, oxidative stress, and tissue damage in the lungs, demonstrating that inhaled nanoplastics from dental and industrial PMMA sources can cause pulmonary harm.