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Toxicities Demonstrated in Dams and Neonates following Intragastric Intubation of Polyethylene Microplastics to Pregnant Mice
Summary
Researchers found that intragastric administration of polyethylene microplastics to pregnant mice caused oxidative stress, inflammation, and reproductive toxicity in dams, with evidence of transplacental transfer producing developmental abnormalities in neonates.
Background: Plastic particles less than 5 mm in diameter (microplastics) are well-known for causing various toxicities such as lung inflammation, oxidative stress, genotoxicity, and reproductive toxicity. As microplastics become smaller, they can move across cell membranes, the placenta, and the blood-brain barrier.
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