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Toxicities Demonstrated in Dams and Neonates following Intragastric Intubation of Polyethylene Microplastics to Pregnant Mice

Korean Journal of Environmental Health Sciences 2021 7 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
YoungMin Song, ChangYul Kim

Summary

Researchers found that intragastric administration of polyethylene microplastics to pregnant mice caused oxidative stress, inflammation, and reproductive toxicity in dams, with evidence of transplacental transfer producing developmental abnormalities in neonates.

Background: Plastic particles less than 5 mm in diameter (microplastics) are well-known for causing various toxicities such as lung inflammation, oxidative stress, genotoxicity, and reproductive toxicity. As microplastics become smaller, they can move across cell membranes, the placenta, and the blood-brain barrier.

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