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20 resultsShowing papers similar to Transcriptome analysis provides insights into copper toxicology in piebald naked carp (Gymnocypris eckloni)
ClearCopper and Microplastic Exposure Affects the Gill Gene Expression of Common Carp During Saltwater Challenge
This study examined how combined copper and microplastic exposure affects gill gene expression in common carp, finding synergistic stress responses including upregulation of genes involved in oxidative stress defense and immune function.
Hepatic transcriptomic and histopathological responses of common carp, Cyprinus carpio, to copper and microplastic exposure
Researchers investigated how PVC microplastics interact with copper exposure in common carp over 14 days. They found that the microplastic particles acted as a vector for copper, increasing its accumulation in the liver and worsening tissue damage beyond what either pollutant caused alone. The study suggests that microplastics can amplify the toxic effects of heavy metals in freshwater fish.
Copper-Induced Ionoregulatory Disturbance, Histopathology, and Transcriptome Responses in Freshwater Mussel (Anodonta woodiana) Gills
Researchers investigated copper toxicity in the freshwater mussel Anodonta woodiana, finding that sublethal exposure caused ionoregulatory disturbance, gill histopathology, and significant transcriptomic changes related to stress response and immune function.
Pre-Exposure of Common Carp to Ambient Copper and Microplastic Changes the Gill Ionoregulaion-Related Transcripts During Saltwater Exposure
Common carp were pre-exposed to copper alone or with polyvinyl chloride microplastics for 14 days, then challenged with brackish water to test how microplastic co-exposure alters gill physiology and metal accumulation. Combined exposure changed gill copper concentrations and altered physiological responses to salinity stress, suggesting microplastics modify how fish handle heavy metal toxicity.
The Combined Effect of Copper Nanoparticles and Microplastics on Transcripts Involved in Oxidative Stress Pathway in Rainbow Trout (Oncorhynchus Mykiss) Hepatocytes
Primary rainbow trout hepatocytes were exposed to copper nanoparticles, microplastics, and their combination for 48 hours, finding that both dissolved copper and copper nanoparticles upregulated antioxidant enzyme transcripts while microplastics alone had minimal effect. Co-exposure to nanoparticles and microplastics did not significantly alter the oxidative stress response beyond nanoparticle effects alone.
Exploration of immune response mechanisms in cadmium and copper co-exposed juvenile golden cuttlefish (Sepia esculenta) based on transcriptome profiling
Researchers used transcriptome analysis to explore immune responses in juvenile golden cuttlefish co-exposed to cadmium and copper, identifying 15 key immune-regulating genes and evidence of inflammatory and innate immune activation.
The effects of exposure to microplastics on grass carp (Ctenopharyngodon idella) at the physiological, biochemical, and transcriptomic levels
Researchers exposed grass carp to microplastics at two concentrations for 21 days and observed liver damage, inhibited growth, and increased oxidative stress. Transcriptome analysis revealed over 1,500 differentially expressed genes related to immune response, metabolism, and cellular stress pathways. The study suggests that microplastic exposure can trigger broad physiological and molecular disruptions in freshwater fish.
Histopathological damage and stress‐ and immune‐related genes' expression in the intestine of common carp, Cyprinus carpio exposed to copper and polyvinyl chloride microparticle
Researchers examined the combined effects of copper and PVC microplastics on common carp intestines, finding that co-exposure caused greater histopathological damage and altered stress- and immune-related gene expression compared to either contaminant alone.
Toxic effects of polyethylene microplastics on transcriptional changes, biochemical response, and oxidative stress in common carp (Cyprinus carpio)
Researchers exposed common carp to varying concentrations of polyethylene microplastics and assessed biochemical, oxidative, and gene expression changes. The study found that microplastic exposure caused significant oxidative stress, altered liver enzyme activity, and modified the expression of stress-related genes in a dose-dependent manner.
Transcriptome Analysis of Gills Provides Insights Into Translation Changes Under Hypoxic Stress and Reoxygenation in Golden Pompano, Trachinotus ovatus (Linnaeus 1758)
This transcriptome study found that oxygen deprivation suppresses immune genes in the gills of golden pompano fish, potentially explaining why fish are more susceptible to infections under low-oxygen aquaculture conditions. The molecular findings support improved oxygen management practices in fish farming to protect both animal welfare and food quality.
New insights into the responding mechanism of Eriocheir sinensis hepatopancreas under nanoplastics and copper stress by transcriptome analysis
Researchers used transcriptome analysis to investigate how nanoplastics and copper individually and in combination affect the hepatopancreas of Chinese mitten crabs. They found that co-exposure led to greater accumulation and more severe tissue damage than either pollutant alone, with significant disruptions to immune and metabolic gene pathways. The study suggests that nanoplastics may enhance the toxicity of heavy metals in aquatic organisms through synergistic interactions.
Combined effects of microplastics and copper on antioxidant capacity, gut microbiome, and metabolomics of Pseudorasbora parva
Researchers studied the combined effects of microplastics and copper on the freshwater fish Pseudorasbora parva, examining antioxidant capacity, gut microbiota, and metabolic responses. They found that the presence of microplastics alongside copper actually reduced copper accumulation in tissues and lessened oxidative damage compared to copper exposure alone. The study suggests that while microplastics can alter the toxicity profile of metals in fish, the interactions are complex and involve metabolic adjustments that balance cellular repair and energy expenditure.
Integrating Transcriptomics and Free Fatty Acid Profiling Analysis Reveal Cu Induces Shortened Lifespan and Increased Fat Accumulation and Oxidative Damage in C. elegans
Researchers found that copper exposure shortened lifespan and induced aging-related phenotypes in C. elegans, with transcriptomics and fatty acid profiling revealing that copper disrupts fatty acid metabolism and increases oxidative damage, providing insights into metal toxicity mechanisms.
Bioinformatics studies and comparison of mRNA transcription of glutathione S-transferase gene in some tissues of common carp (Cyprinus carpio) and brown trout (Salmo trutta)
Not relevant to microplastics — this study compares gene expression of glutathione S-transferase (a detoxification enzyme) across multiple tissues in common carp and brown trout using bioinformatics and qPCR.
Transcriptome and Gene Family Analyses Reveal the Physiological and Immune Regulatory Mechanisms of Channa maculata Larvae in Response to Nanoplastic-Induced Oxidative Stress
Researchers exposed larvae of blotched snakehead fish to polystyrene nanoplastics at concentrations ranging from 0.05 to 20 mg/L and observed concentration-dependent damage to the liver and intestines. The nanoplastics triggered oxidative stress responses and affected genes involved in immune regulation and detoxification. The study suggests that nanoplastic pollution during early fish development could compromise both organ function and immune defenses.
Transcriptome Analysis Revealed the Early Heat Stress Response in the Brain of Chinese Tongue Sole (Cynoglossus semilaevis)
Researchers used transcriptome analysis to study how the brains of Chinese tongue sole fish respond to short-term heat stress. They identified distinct gene expression patterns in male and female fish, with key pathways related to cortisol production, immune signaling, and stress-response genes like heat shock proteins. The study provides new insights into the sex-specific brain mechanisms fish use to cope with temperature changes.
Natural Bioactive Phytocompounds to Reduce Toxicity in Common Carp Cyprinus carpio: A Challenge to Environmental Risk Assessment of Nanomaterials
Researchers investigated the toxic effects of copper oxide nanoparticles on common carp and found that Myristica fragrans seed extract provided protective benefits by reducing oxidative stress and mitigating nanoparticle-induced damage.
Toxic Effect of Combined Exposure of Microplastics and Copper on Goldfish (Carassius auratus): Insight from Oxidative Stress, Inflammation, Apoptosis and Autophagy in Hepatopancreas and Intestine
Researchers found that combined exposure to microplastics and copper in goldfish significantly enhanced copper accumulation and tissue damage in the hepatopancreas and intestine, triggering oxidative stress, inflammation, apoptosis, and autophagy beyond the effects of either pollutant alone.
Toxicity of microplastics and copper, alone or combined, in blackspot seabream (Pagellus bogaraveo) larvae
Researchers examined the toxicity of microplastics and copper, alone and combined, on blackspot seabream larvae, finding that microplastic-copper mixtures can alter biochemical biomarkers and gene expression related to oxidative stress and immune response in developing fish.
Differential Cell Metabolic Pathways in Gills and Liver of Fish (White Seabream Diplodus sargus) Coping with Dietary Methylmercury Exposure
Researchers investigated differential metabolic responses in the gills and liver of white seabream exposed to dietary methylmercury, revealing tissue-specific detoxification pathways and cellular stress responses that help explain how fish cope with chronic mercury exposure.