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Transcriptome analysis provides insights into copper toxicology in piebald naked carp (Gymnocypris eckloni)
Summary
Researchers exposed piebald naked carp to copper — a common water pollutant — and found it significantly disrupted gene activity in the gills and liver, particularly genes involved in building proteins, suggesting that fish respond to metal-induced stress by broadly slowing down protein production as a protective mechanism.
Our results indicate that copper exposure caused different responses in different tissues, since the gene expression patterns changed substantially either in the gills or liver, while the effect on the kidney was relatively weak. Furthermore, our results indicated that the expression pattern of the genes involved in the ribosome, which is a complex molecular machine orchestrating protein synthesis in the cell, together with translation initiation factor and elongation factors, were affected by copper exposure both in the gills and liver of piebald naked carp. This result leads us to speculate that the downregulation of global protein synthesis is an acute response strategy of fish to metal-induced oxidative stress. Moreover, we speculate that this strategy not only exists in the selective translation of proteins but also exists in the specific translation of functional proteins in tissues and cells.
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