Papers

61,005 results
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Article Tier 2

Effects of natural organic matter on the joint toxicity and accumulation of Cu nanoparticles and ZnO nanoparticles in Daphnia magna

Researchers tested how copper and zinc oxide nanoparticle mixtures affect the water flea Daphnia magna in the presence and absence of natural organic matter, finding additive-to-synergistic joint toxicity and showing that natural organic matter shifts the dominant toxic species toward dissolved zinc ions while increasing nanoparticle accumulation in the organism's body.

2021 Environmental Pollution 27 citations
Article Tier 2

Toxicological Mechanism of the Size–Form Synergy of Nano-Copper Oxide in Danio rerio

This study compared the toxicity of copper oxide nanoparticles (CuO-NPs) of different sizes and morphologies in zebrafish (Danio rerio). Smaller CuO-NPs caused greater oxidative stress and developmental toxicity, demonstrating that particle size and form are key determinants of nanotoxicity in aquatic organisms.

2025 Biology
Article Tier 2

Impact and Molecular Mechanism of Microplastics on Zebrafish in the Presence and Absence of Copper Nanoparticles

Polystyrene microplastics of three sizes combined with copper nanoparticles caused additive or synergistic toxicity in zebrafish, disrupting oxidative stress responses, gene expression, and early development, with 0.07-micrometer particles producing the most severe effects.

2021 Frontiers in Marine Science 23 citations
Article Tier 2

Bioaccumulation Behaviors of Copper Phthalocyanine Nano-pigments in Adult Zebrafish (Danio rerio)

Researchers found that copper phthalocyanine (CuPc) blue nano-pigments — widely used in consumer products — bioaccumulate in zebrafish liver and muscle tissue after aquatic exposure, raising concerns about their potential ecological and health effects in aquatic food chains.

2023 E3S Web of Conferences 1 citations
Article Tier 2

Toxic Effects and Mechanisms of Silver and Zinc Oxide Nanoparticles on Zebrafish Embryos in Aquatic Ecosystems

Researchers tested the toxic effects of silver and zinc oxide nanoparticles on zebrafish embryos in natural water environments. They found that both nanoparticle types caused acute toxicity, increased oxidative stress, apoptosis, and autophagy, though toxicity was lower in natural water compared to pure water due to environmental interactions. The study suggests that the complex components in natural water may transform nanoparticles in ways that reduce but do not eliminate their harmful effects on aquatic organisms.

2022 Nanomaterials 51 citations
Article Tier 2

The Toxic Effect of Cu and CuO Nanoparticles on Euplotes Aediculatus

Copper and copper oxide nanoparticles were found to be toxic to the single-celled organism Euplotes aediculatus, causing oxidative damage and physical changes to the cell. These nanoparticle toxicity findings are relevant to understanding how nanoplastics and co-occurring metal pollutants affect aquatic organisms.

2021 Research Square (Research Square) 1 citations
Article Tier 2

Particles rather than released Zn2+ from ZnO nanoparticles aggravate microplastics toxicity in early stages of exposed zebrafish and their unexposed offspring

Researchers investigated the combined effects of polystyrene microplastics and zinc oxide nanoparticles on zebrafish embryos and their unexposed offspring. They found that ZnO particles adhered to microplastic surfaces and amplified toxic effects including growth inhibition, oxidative stress, and hormonal disruption, with impacts carrying over to the next generation. Interestingly, dissolved zinc ions actually reversed some microplastic toxicity, suggesting that it is the physical particles rather than the released zinc that drive the increased harm.

2021 Journal of Hazardous Materials 75 citations
Article Tier 2

Combined Effects of Test Media and Dietary Algae on the Toxicity of CuO and ZnO Nanoparticles to Freshwater Microcrustaceans Daphnia magna and Heterocypris incongruens: Food for Thought

Researchers examined the combined effects of test media composition and dietary algae on the toxicity of CuO and ZnO nanoparticles to Daphnia magna and Heterocypris incongruens in both mineral and natural lake water. The study found that the presence of algae and water chemistry significantly altered nanoparticle bioavailability and toxicity outcomes for both species.

2018 Nanomaterials 24 citations
Article Tier 2

Polystyrene microplastics facilitate the biotoxicity and biomagnification of ZnO nanoparticles in the food chain from algae to daphnia

Researchers found that polystyrene microplastics enhanced the toxicity and biological accumulation of zinc oxide nanoparticles in an aquatic food chain from algae to water fleas. When both pollutants were present together, water fleas showed increased oxidative stress, higher heart rates, and greater zinc accumulation compared to exposure to either pollutant alone. The study demonstrates that microplastics can amplify the harmful effects of other nanoparticle contaminants as they move through the food chain.

2023 Environmental Pollution 34 citations
Article Tier 2

Influence of nanoparticles of industrial plastics on model fish Danio rerio (Hamilton, 1822)

This study examined the effects of industrial plastic nanoparticles on zebrafish (Danio rerio) at concentrations relevant to natural water bodies, focusing on their ability to penetrate living cells by endocytosis and cause toxic effects in aquatic organisms.

2024 Водные биоресурсы и среда обитания
Article Tier 2

Individual and Combined Toxic Effects of Nano-ZnO and Polyethylene Microplastics on Mosquito Fish (Gambusia holbrooki)

Researchers studied the individual and combined effects of polyethylene microplastics and zinc oxide nanoparticles on mosquito fish. The combination caused greater damage to liver tissue, blood parameters, and antioxidant systems than either pollutant alone. The findings suggest that microplastics interacting with other environmental contaminants can amplify toxic effects in aquatic organisms.

2023 Water 36 citations
Article Tier 2

Combined effects of microplastics and copper on oxidative responses in zebrafish (Danio rerio)

Researchers exposed zebrafish (Danio rerio) to microplastics (10 µg/L) and copper (45 µg/L) individually and in combination, finding that fish exposed to both stressors simultaneously exhibited higher oxidative stress across multiple body organs than those exposed to either contaminant alone.

2025 JOURNAL OF EXPERIMENTAL ZOOLOGY INDIA
Article Tier 2

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

This review summarizes research on how various nanomaterials, including nano-sized plastics, affect zebrafish, which are commonly used as stand-ins for studying human health effects. Exposure to nanomaterials caused developmental defects, organ damage, behavioral changes, and reproductive problems in zebrafish. These findings help scientists understand the potential health risks of nanomaterial exposure to humans and the environment.

2024 International Journal of Molecular Sciences 35 citations
Article Tier 2

Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment

This review examines how nano- and micro-sized plastic particles cause toxic effects in zebrafish, focusing on the link between oxidative stress and neurodevelopmental damage. Researchers found that plastic particle exposure disrupts the balance of reactive oxygen species in cells, which can impair brain development and nervous system function. The study suggests these oxidative stress responses may serve as early warning signals of plastic particle toxicity in aquatic organisms.

2023 Animals 28 citations
Article Tier 2

Potential Toxicity in Crucian Carp Following Exposure to Metallic Nanoparticles of Copper, Chromium, and Their Mixtures: A Comparative Study

Copper and chromium nanoparticles were tested for toxicity in crucian carp, finding that mixtures of the two metals caused more harm than either alone. While focused on metal nanoparticles rather than nanoplastics, the findings are relevant because metals commonly attach to the surface of microplastics in water.

2017 Polish Journal of Environmental Studies 11 citations
Article Tier 2

The Role of Synthetic Polymers in the Aquatic Environment and Its Implications in Danio Rerio as a Model Organism

Exposing zebrafish to polystyrene microplastics combined with silver nanoparticles caused significantly more oxidative damage, tissue injury in gills and intestines, and higher mortality than either contaminant alone. The study demonstrates that microplastics can act as carriers that enhance the toxicity of co-pollutants like silver nanoparticles, a combination effect that is highly relevant to understanding real-world aquatic contamination where multiple pollutants co-occur.

2023 Apple Academic Press eBooks
Article Tier 2

Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos

Researchers investigated the toxicity of zinc oxide nanoparticles on human brain glial cells and zebrafish embryos, finding that both were harmed at relatively low concentrations. The nanoparticles reduced cell viability in the glial cells and caused developmental abnormalities in the zebrafish embryos. The study suggests that the dissolved zinc ions released from these widely used nanoparticles play a significant role in their toxic effects on the nervous system.

2023 International Journal of Molecular Sciences 29 citations
Article Tier 2

Toxicological assessment of nanoparticles and microplastics

This review examines the toxicological effects of nanoparticles and microplastics on aquatic organisms, summarizing mechanisms of harm including oxidative stress, inflammatory responses, DNA damage, tissue injury, and neurological disruption in fish. It highlights that secondary nanoplastics formed from macro- and microplastic degradation are more heterogeneous than primary particles, and that combined exposure with chemical pollutants amplifies toxicity, including the capacity to cross the blood-brain barrier in fish.

2022 Biomedical Letters 2 citations
Article Tier 2

Combined toxic effects of environmental predominant microplastics and ZnO nanoparticles in freshwater snail Pomaceae paludosa

Researchers assessed the toxic effects of zinc oxide nanoparticles and polypropylene microplastics, both individually and combined, on the freshwater snail Pomeacea paludosa over 28 days. The study found that combined exposure caused more severe oxidative stress, disrupted antioxidant and digestive enzyme activity, and led to tissue damage and DNA damage compared to individual pollutant exposure. Evidence indicates that microplastics interacting with nanoparticles can amplify toxic effects in freshwater organisms.

2023 Environmental Pollution 25 citations
Article Tier 2

Exposure to Nanoplastics Cause Caudal Vein Plexus Damage and Hematopoietic Dysfunction by Oxidative Stress Response in Zebrafish (Danio rerio)

Researchers found that nanoplastic exposure in zebrafish embryos caused damage to blood vessel development and impaired the formation of blood cells. The nanoplastics triggered oxidative stress in vascular and blood-forming cells, disrupting normal developmental processes. The study suggests that nanoplastic contamination in aquatic environments could affect early development in fish by interfering with their circulatory and blood cell production systems.

2024 International Journal of Nanomedicine 4 citations
Article Tier 2

Contribution of additive-related effects to microplastics toxicity for aquatic organisms: a case study with model metal (ZnO) and organic additives (Lubio) and LDPE

Researchers produced well-defined LDPE microplastic particles loaded with model additives (ZnO nanoparticles and a commercial Lubio antiaging system) to isolate and quantify additive-related contributions to microplastic toxicity in Daphnia magna and Tetrahymena thermophila. Results showed ZnO nanoparticles were acutely toxic while additive-free and Lubio-loaded particles demonstrated differing toxicity profiles, providing a framework for disentangling polymer versus additive effects in ecotoxicity studies.

2022 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Mitochondrial dysfunction and lipometabolic disturbance induced by the co-effect of polystyrene nanoplastics and copper impede early life stage development of zebrafish (Danio rerio)

Researchers found that co-exposure to polystyrene nanoplastics and copper at environmentally relevant concentrations caused mitochondrial dysfunction and lipid metabolism disruption in zebrafish embryos, impairing early development and survival more severely than either contaminant alone.

2022 Environmental Science Nano 7 citations
Article Tier 2

Effects of copper in Daphnia are modulated by nanosized titanium dioxide and natural organic matter: what is the impact of aging duration?

This study examined how titanium dioxide nanoparticles interact with natural organic matter to modify the toxicity of copper to the freshwater crustacean Daphnia magna. It is an aquatic toxicology study focused on nanoparticle-metal interactions rather than microplastics specifically.

2020 Environmental Science and Pollution Research 4 citations
Article Tier 2

Single and combined acute and subchronic toxic effects of microplastics and copper in zebrafish (Danio rerio) early life stages

Researchers exposed zebrafish embryos and larvae to microplastics, copper, and their combinations to assess individual and combined toxic effects. They found that microplastics alone caused limited harm, but when combined with copper, the mixture produced altered biochemical responses and changes in gene expression. The study suggests that microplastics can modify the toxicity of heavy metals in aquatic organisms during early development.

2021 Chemosphere 96 citations