Papers

61,005 results
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Article Tier 2

The protective efficacy of dual dietary rosemary plus cinnamon mix against lead nitrate-induced immune suppression, genotoxicity, and oxidant/antioxidant status in Nile tilapia fingerlings

Researchers tested whether a dietary mix of rosemary and cinnamon could protect Nile tilapia from the harmful effects of lead exposure. Fish exposed to lead showed reduced growth, suppressed immunity, increased oxidative stress, and DNA damage, but those fed the herbal supplement showed significant improvements across all measures. The study suggests that rosemary and cinnamon supplementation may help mitigate heavy metal toxicity in farmed fish.

2023 Aquaculture International 11 citations
Article Tier 2

Dietary Arthrospira platensis in Rainbow Trout (Oncorhynchus mykiss): A Means to Reduce Threats Caused by CdCl2 Exposure?

Researchers investigated whether dietary Spirulina supplementation could protect rainbow trout from cadmium chloride toxicity, evaluating growth performance, immune response, and tissue damage to assess its potential as a protective feed additive in aquaculture.

2022 Toxics 32 citations
Article Tier 2

Evaluating Silymarin Extract as a Potent Antioxidant Supplement in Diazinon-Exposed Rainbow Trout: Oxidative Stress and Biochemical Parameter Analysis

This study tested whether silymarin, a natural antioxidant from milk thistle, could protect rainbow trout from liver damage caused by the pesticide diazinon. Silymarin successfully reduced oxidative stress and restored many blood markers to normal levels in the exposed fish. While not directly about microplastics, the research is relevant because microplastics in water can carry pesticides like diazinon, and understanding protective compounds could help address the combined toxic effects of these pollutants on aquatic food sources.

2023 Toxics 52 citations
Article Tier 2

Ameliorative Hematological and Histomorphological Effects of Dietary Trigonella foenum-graecum Seeds in Common Carp (Cyprinus carpio) Exposed to Copper Oxide Nanoparticles

Researchers tested dietary fenugreek seed extract as a protective supplement in common carp exposed to copper oxide nanoparticles at 1.5 mg per liter. Fenugreek supplementation at 125-150 mg per liter reduced hematological toxicity and improved tissue histomorphology in fish exposed to CuO nanoparticles, suggesting potential as a nutraceutical mitigation strategy.

2022 International Journal of Environmental Research and Public Health 19 citations
Article Tier 2

Natural Bioactive Phytocompounds to Reduce Toxicity in Common Carp Cyprinus carpio: A Challenge to Environmental Risk Assessment of Nanomaterials

Researchers investigated the toxic effects of copper oxide nanoparticles on common carp and found that Myristica fragrans seed extract provided protective benefits by reducing oxidative stress and mitigating nanoparticle-induced damage.

2023 Water 11 citations
Article Tier 2

A Comprehensive Review on Cadmium Toxicity in Freshwater Fish: Physiological, Ecological and Health Implications

This comprehensive review examines cadmium toxicity in freshwater fish, covering physiological damage to gills, kidneys, liver, and gonads, ecological impacts on fish populations, and implications for human health through consumption of cadmium-contaminated aquatic food.

2025 Asian Journal of Research in Zoology
Article Tier 2

Dietary Curcumin Promotes Gilthead Seabream Larvae Digestive Capacity and Modulates Oxidative Status

Adding curcumin to the diet of gilthead seabream larvae improved their digestive capacity and antioxidant status. The research explores natural dietary supplements for improving fish health in aquaculture, which is relevant as farmed seafood is a source of microplastic exposure for humans.

2021 Animals 19 citations
Article Tier 2

Enhanced Immune Response Improves Resistance to Cadmium Stress in Triploid Crucian Carp

This study found that triploid crucian carp exhibit enhanced immune responses compared to diploid fish, which may contribute to their greater resistance to cadmium-induced stress.

2021 Frontiers in Physiology 17 citations
Article Tier 2

Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes

Researchers synthesized a novel compound called dimethyl bisphenolate and tested its ability to protect against chemically induced liver injury in rats and cell models. They found that the compound significantly reduced liver damage markers and oxidative stress in a dose-dependent manner, with effects comparable to the established liver protectant silymarin. The study suggests that dimethyl bisphenolate may help protect liver cells by regulating oxidative stress pathways and reducing cell death.

2023 Molecules 6 citations
Article Tier 2

Unveiling the Effects of Fennel (Foeniculum vulgare) Seed Essential Oil as a Diet Supplement on the Biochemical Parameters and Reproductive Function in Female Common Carps (Cyprinus carpio)

Researchers investigated the effects of fennel seed essential oil on the health and reproductive function of common carp over 60 days. At lower doses, the oil improved growth rates and immune parameters, while the highest dose elevated stress-related enzyme levels. The study suggests that fennel oil at moderate doses could serve as a beneficial dietary supplement for farmed fish.

2023 Water 24 citations
Article Tier 2

Effect of dietary Bacillus subtilis supplement on Cd toxicokinetics and Cd-induced immune and antioxidant impairment of Procambarus clarkii

Researchers exposed red swamp crayfish to cadmium at 0.1 and 1.0 mg/L with and without dietary Bacillus subtilis supplementation, finding dose- and time-dependent cadmium accumulation with gills showing highest uptake, and demonstrating that Bacillus subtilis supplementation ameliorated cadmium-induced immune and antioxidant impairment across crayfish tissues.

2022 Research Square (Research Square)
Article Tier 2

Effects of Dietary Rosemary ( Rosmarinus officinalis ) Leaf Powder and Bacillus subtilis on the Growth Performance, Digestive Enzymes, Antioxidant and Immune-Related Gene Expression, and Resistance to Aeromonas hydrophila in Common Carp, Cyprinus carpio

Common carp supplemented with rosemary leaf powder and/or Bacillus subtilis for 56 days showed improved growth, antioxidant enzyme activity, innate immunity, and resistance to Aeromonas hydrophila infection, demonstrating potential as natural feed additives in aquaculture.

2024 Annals of Animal Science
Article Tier 2

Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota

Researchers found that selenium-containing polysaccharide from Spirulina platensis alleviates cadmium-induced liver toxicity in mice by modulating gut microbiota composition and suppressing inflammatory pathways, suggesting a protective role against heavy metal exposure.

2022 Frontiers in Nutrition 25 citations
Article Tier 2

Prefeeding of Clarias gariepinus with Spirulina platensis counteracts petroleum hydrocarbons-induced hepato- and nephrotoxicity

Researchers tested whether feeding catfish (Clarias gariepinus) the microalgae Spirulina platensis before exposing them to petroleum pollutants benzene and toluene could protect their liver and kidneys, finding that Spirulina significantly restored normal organ function and reduced tissue damage. While kidney tissue still showed some injury, the study suggests Spirulina's antioxidant properties can meaningfully shield fish from hydrocarbon pollution.

2024 Scientific Reports 4 citations
Article Tier 2

Toxic Effects of Cadmium on Fish

This review examines how cadmium, a toxic heavy metal released from industrial activities, accumulates in fish tissues and causes widespread organ damage. Researchers found that cadmium affects fish liver, kidneys, gills, and reproductive systems through oxidative stress and disruption of normal cellular processes. The study also discusses the potential risks of cadmium exposure to humans who consume contaminated fish.

2022 Toxics 131 citations
Article Tier 2

Ameliorating potential of Cassia absus seed-powder against cadmium-induced alterations in Zebrafish and identification of flavonoids in different extracts of seed

Researchers investigated the protective effects of Cassia absus seed powder against cadmium-induced toxicity in zebrafish, finding it reduced oxidative stress and histological damage, while identifying flavonoid compounds in the seed extracts as likely active components.

2021 Exploratory Animal and Medical Research 6 citations
Article Tier 2

Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin

Researchers examined the liver toxicity of polystyrene microplastic particles in adult male rats and evaluated whether silymarin, a liver-protective compound, could mitigate the damage. The study found that exposure to 1 and 5 micrometer microplastics induced liver injury through pyroptosis, oxidative stress, and fibrotic changes, and that silymarin treatment showed potential therapeutic effects against these microplastic-induced injuries.

2023 Toxicology Mechanisms and Methods 20 citations
Article Tier 2

Protective Effects of Curcumin and/or Ginger Supplementation against Oreochromis niloticus Oxidative Stress Induced by Ultraviolet-A Radiation

Researchers found that dietary supplementation with curcumin and/or ginger significantly protected Nile tilapia from oxidative stress induced by ultraviolet-A radiation, improving antioxidant enzyme activity and reducing DNA fragmentation and lipid peroxidation. The findings suggest these natural compounds can serve as effective antioxidant feed additives in aquaculture.

2023 Egyptian Journal of Aquatic Biology and Fisheries 2 citations
Article Tier 2

Mechanisms of Gills Response to Cadmium Exposure in Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis): Oxidative Stress, Immune Response, and Energy Metabolism

This study examined how cadmium, a toxic heavy metal from industrial pollution, damages the gills of a marine fish species by triggering oxidative stress, immune responses, and energy imbalances. While not directly about microplastics, the findings are relevant because microplastics can absorb and transport heavy metals like cadmium into aquatic food chains. Understanding how fish respond to cadmium exposure helps assess the combined risks when heavy metals hitchhike on microplastic particles.

2024 Animals 15 citations
Article Tier 2

Ferrous Ion Alleviates Lipid Deposition and Inflammatory Responses Caused by a High Cottonseed Meal Diet by Modulating Hepatic Iron Transport Homeostasis and Controlling Ferroptosis in Juvenile Ctenopharyngodon idellus

Researchers investigated whether ferrous ion supplementation could mitigate the lipid deposition and inflammatory responses caused by high cottonseed meal diets in juvenile grass carp, finding that Fe2+ addition at 0.2% and 0.4% levels modulated hepatic iron transport homeostasis and controlled ferroptosis over an eight-week feeding trial.

2023 Antioxidants 4 citations
Article Tier 2

Effect of Scoparia dulcis Extract on Lipid Oxidation in Fish Feed, Growth Performance, and Hypoxia Tolerance in Juvenile Jian Carp (Cyprinus carpio var. Jian)

This paper is not relevant to microplastics research; it investigates the effects of Scoparia dulcis plant extracts on lipid oxidation in fish feed and growth performance in Jian carp, focusing on antioxidant and digestive outcomes.

2024 Aquaculture Nutrition 2 citations
Article Tier 2

Natural-based solutions to mitigate dietary microplastics side effects in fish

Zebrafish reared for 6 months on diets containing microencapsulated astaxanthin and microplastics showed reduced oxidative stress and lower MP accumulation in liver compared to controls, suggesting antioxidant supplementation can mitigate the toxicological effects of dietary microplastic exposure.

2024 Chemosphere 5 citations
Article Tier 2

Seasonal assessment of selected trace elements in grass carp (Ctenopharyngodon idella) blood and their effects on the biochemistry and oxidative stress markers

Researchers monitored trace metal concentrations in the blood of grass carp across seasons and found significant seasonal differences, along with statistical links between metals like zinc, iron, and copper and markers of liver function, oxidative stress, and metabolism. The findings show that environmental metal pollution has measurable physiological effects on freshwater fish, which are continuously exposed through their aquatic habitat.

2023 Environmental Monitoring and Assessment 11 citations
Article Tier 2

Dietary Pectin Supplementation as a Potential Strategy to Mitigate the Toxic Effects of Microplastics and Cadmium in Freshwater Crayfish ( Astacus leptodactylus )

Researchers investigated whether dietary pectin supplementation could mitigate the toxic effects of microplastics and cadmium exposure in freshwater crayfish. Pectin partially restored some antioxidant enzyme activities and normalized certain biochemical markers disrupted by the pollutant exposure. However, because the crayfish were directly exposed to the contaminants in water, oral pectin supplementation had limited protective effects on several key health parameters, suggesting that dietary interventions alone may not fully counteract environmental pollutant exposure.

2026 Aquaculture Research