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61,005 resultsShowing papers similar to Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice
ClearDual impact of microplastic exposure in a mouse model: Impaired uterine receptivity and altered maternal-offspring metabolism
Researchers exposed female mice to polystyrene microplastics and found that the particles impaired uterine receptivity, which is critical for embryo implantation, and altered metabolic profiles in both the mothers and their offspring. The microplastics disrupted gene expression related to uterine function and caused metabolic changes across multiple organs. The findings suggest that microplastic exposure could have reproductive and metabolic consequences that extend to the next generation.
Immunotoxicological disruption of pregnancy as a new research area in immunotoxicology
This review examines how environmental chemicals, including microplastics, can disrupt the immune system during pregnancy and increase the risk of miscarriage. Studies in mice and humans have shown that microplastic exposure during pregnancy can damage the placenta's immune system, interfere with signaling between mother and fetus, and contribute to pregnancy loss. The findings highlight an emerging concern that microplastic exposure may pose particular risks to reproductive health during pregnancy.
Polystyrene microplastics disturb maternal glucose homeostasis and induce adverse pregnancy outcomes
Pregnant mice exposed to polystyrene microplastics developed abnormal blood sugar levels and experienced poor pregnancy outcomes, including placental damage and restricted fetal growth. The study found that microplastics disrupted glucose metabolism through inflammation and a cellular stress response, suggesting that microplastic exposure during pregnancy could contribute to complications similar to gestational diabetes.
Maternal exposure to polystyrene microplastics alters placental metabolism in mice
Researchers exposed pregnant mice to polystyrene microplastics and examined how placental metabolism was affected. The study found significant changes in placental metabolic pathways that could help explain the fetal growth restriction previously observed in microplastic-exposed pregnancies. These findings suggest that microplastic exposure during pregnancy may interfere with the placenta's ability to support normal fetal development.
Polystyrene microplastics impaired decidualization in mice via oxidative stress and inflammation and disrupted the reproductive function of their female offspring
Mouse experiments found that polystyrene microplastics impaired uterine decidualization and embryo implantation via oxidative stress and inflammation, and that maternal PS-MP exposure also disrupted the reproductive function of female offspring.
Exposure to polystyrene microplastics during lactational period alters immune status in both male mice and their offspring
This study found that when male mice were exposed to polystyrene microplastics during the nursing period, both the adult mice and their offspring showed changes in immune cell populations in the spleen. The microplastics altered the balance of different types of immune cells, suggesting the immune system was being disrupted. This is especially concerning because it shows that microplastic exposure during early life can affect immune development in the next generation.
Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice
Researchers exposed pregnant mice to polystyrene micro and nanoplastics and found that exposure caused fetal growth restriction and placental abnormalities. The study observed that plastic particles accumulated in placental tissue and disrupted normal placental function. These findings raise concern that maternal exposure to plastic particles during pregnancy may interfere with fetal development.
Gestational exposure to micro- and nanoplastics leads to poor pregnancy outcomes by impairing placental trophoblast syncytialization
Researchers found that exposing pregnant mice to micro- and nanoplastics led to increased embryo loss, reduced embryonic weight, and smaller placentas. The plastic particles impaired a critical process called syncytialization, where placental cells fuse together to form a functional barrier, by activating a stress-response signaling pathway. The study suggests that prenatal microplastic exposure could disrupt placental development and contribute to poor pregnancy outcomes.
Exposure to Polystyrene Nanoplastics Compromise Ovarian Reserve Function and Endometrial Decidualization in Early Pregnant Mice
Female mice exposed to polystyrene nanoplastics for 90 days before pregnancy had fewer successful pregnancies, smaller pups, and damaged ovaries with reduced egg counts. The nanoplastics disrupted key reproductive hormones and interfered with the uterine process needed for embryo implantation. This study raises concerns that nanoplastic exposure through food and water could harm female fertility and pregnancy outcomes in humans.
Polystyrene nanoparticles induced adverse pregnancy outcomes via the activation of placental ferroptosis and gut microbiota dysfunction
Researchers exposed pregnant mice to 50-nanometer polystyrene nanoparticles and found that the particles caused adverse pregnancy outcomes through two interconnected mechanisms: disruption of gut microbiota and activation of ferroptosis in placental tissue. The nanoparticle exposure altered the composition of beneficial gut bacteria and triggered iron-dependent cell death in the placenta. The study suggests that maternal exposure to nanoplastics during pregnancy may threaten reproductive health through gut-placenta axis disruption.
Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice
Researchers exposed pregnant mice to polystyrene nanoplastics through drinking water and found that higher concentrations led to significantly reduced fetal weight. The nanoplastics caused abnormal cell structures in the placenta and disrupted metabolic processes in both placental tissue and fetal livers. The study suggests that maternal nanoplastic exposure during pregnancy can cross the placental barrier and interfere with normal fetal growth and metabolism.
Gestational exposure to polystyrene microplastics incurred placental damage in mice: Insights into metabolic and gene expression disorders
This mouse study found that when pregnant mice were exposed to tiny polystyrene microplastics (0.1 micrometers), the particles crossed the placenta and reached fetal livers and brains, causing placental damage and impaired fetal development. Larger microplastics (5 micrometers) were less able to cross the placenta, suggesting that the smallest plastic particles pose the greatest risk during pregnancy.
Gut microbiota participates in polystyrene microplastics-induced defective implantation through impairing uterine receptivity
Researchers found that oral exposure to polystyrene microplastics in mice impaired the ability of embryos to implant in the uterus by disrupting uterine receptivity. The study revealed that microplastics altered gut bacteria composition, which in turn affected hormone signaling and gene expression in the uterus. These findings suggest a gut-reproductive axis through which microplastic exposure could potentially affect fertility.
Adverse effects of a realistic concentration of human exposure to microplastics on markers of placental barrier permeability in pregnant rats
Researchers exposed pregnant rats to polystyrene microplastics at concentrations realistic for human exposure and examined effects on the placenta. They found that the microplastics accumulated in placental tissue, caused oxidative stress, triggered cell death, and reduced the expression of proteins that maintain the placental barrier. The study provides the first evidence that realistic levels of microplastic exposure can compromise the protective barrier between mother and developing offspring.
Maternal ingestion of polyethylene microplastics results in reduced antiviral responses by dysregulating the immune system in their progeny
Researchers found that mice exposed to polyethylene microplastics during pregnancy transferred particles to offspring, and those offspring showed impaired antiviral immune responses. The findings suggest that maternal microplastic exposure can programme immune dysfunction in the next generation through disruption of developing immune systems.
Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring
Researchers exposed pregnant mice to polystyrene microplastics during pregnancy and nursing and found significant metabolic disruptions in both the mothers and their offspring across two generations. The microplastics altered lipid metabolism, gut microbiota composition, and key metabolic signaling pathways. The study suggests that microplastic exposure during critical developmental windows may have lasting health consequences that pass to future generations.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers exposed pregnant mice to nanoscale polystyrene particles through inhalation and tracked where the particles traveled. They found that the nanoplastics crossed from the lungs into the bloodstream and accumulated in both placental and fetal tissues, confirming that inhaled plastic nanoparticles can reach developing offspring during pregnancy.
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy
Researchers found that nanoscale polystyrene particles inhaled by pregnant mice were able to cross into the placenta and deposit in fetal tissues. The findings raise concerns about potential developmental risks from airborne nanoplastic exposure during pregnancy.
Intergenerational and transgenerational reproductive toxicity of polystyrene microplastics in female mice
Female mice were exposed to polystyrene microplastics during lactation and researchers tracked reproductive outcomes in both exposed mothers and their offspring through multiple generations, finding that even at doses comparable to human infant bottle-feeding exposure, microplastics induced ovarian damage and reduced fertility that persisted across generations.
Polystyrene Microplastics Disrupt Vertical Transmission of the Breast Milk Microbiome, Impairing Early‐Life Gut Colonization and Immune Development in Offspring
Researchers exposed pregnant and lactating mice to polystyrene microplastics and found that maternal exposure disrupted the breast milk microbiome, reducing beneficial bacteria like Ligilactobacillus while increasing potentially harmful ones. Offspring from exposed mothers showed altered gut colonization, excessive weight gain, reduced immune markers, and compromised intestinal barrier integrity, suggesting microplastics may affect infant development through changes in breast milk composition.
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
When pregnant mice were exposed to nanoplastics during pregnancy and nursing, their female offspring had significantly reduced fertility as adults. The nanoplastics caused premature activation of egg cells in the ovaries and damaged crucial connections between eggs and their supporting cells. This raises concerns that a mother's exposure to nanoplastics could have lasting effects on her daughters' ability to have children.
Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage
Exposure to polystyrene nanoplastics triggered a cell death pathway in the placental cells (trophoblasts) that are essential for maintaining pregnancy, leading to miscarriage in mice. This finding raises concerns that nanoplastic exposure during pregnancy could harm fetal development by damaging the critical cells that connect mother and baby.
Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics throughout mating, pregnancy, and nursing, then examined the ovaries of their female offspring. They found that maternal nanoplastic exposure significantly reduced ovarian weight and follicle numbers in the offspring and lowered the expression of key antioxidant genes. The study suggests that nanoplastic exposure during pregnancy may pose risks to the reproductive development of female offspring.
Polystyrene micro- and nanoplastics cause placental dysfunction in mice
Pregnant mice exposed to polystyrene micro- and nanoplastics in drinking water showed signs of placental dysfunction, with nanoplastics causing more severe effects than microplastics. Both sizes triggered a brain-sparing response in fetuses, where blood flow is redirected to protect the brain from low oxygen, a sign of fetal distress. These findings suggest that nanoplastic exposure during pregnancy could disrupt normal placental function and potentially affect fetal brain development.