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Article
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AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button.
Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Nanoplastics
Reproductive & Development
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Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage
Particle and Fibre Toxicology
2024
82 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Shukun Wan,
Xiaoqing Wang,
Weina Chen,
Manli Wang,
Jingsong Zhao,
Zhongyan Xu,
Rong Wang,
Chenyang Mi,
Zhaodian Zheng,
Huidong Zhang
Summary
Exposure to polystyrene nanoplastics triggered a cell death pathway in the placental cells (trophoblasts) that are essential for maintaining pregnancy, leading to miscarriage in mice. This finding raises concerns that nanoplastic exposure during pregnancy could harm fetal development by damaging the critical cells that connect mother and baby.
Exposure to PS-NPs activated Bcl-2/Cleaved-caspase-2/Cleaved-caspase-3, leading to excessive apoptosis in human trophoblast cells and in mice placental tissues, further inducing miscarriage.