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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Reproductive & Development Sign in to save

Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage

Particle and Fibre Toxicology 2024 82 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 70 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Shukun Wan, Shukun Wan, Shukun Wan, Shukun Wan, Xiaoqing Wang, Weina Chen, Weina Chen, Manli Wang, Zhongyan Xu, Xiaoqing Wang, Zhongyan Xu, Jingsong Zhao, Jingsong Zhao, Zhongyan Xu, Zhongyan Xu, Manli Wang, Rong Wang, Huidong Zhang Chenyang Mi, Chenyang Mi, Zhaodian Zheng, Zhaodian Zheng, Huidong Zhang

Summary

Exposure to polystyrene nanoplastics triggered a cell death pathway in the placental cells (trophoblasts) that are essential for maintaining pregnancy, leading to miscarriage in mice. This finding raises concerns that nanoplastic exposure during pregnancy could harm fetal development by damaging the critical cells that connect mother and baby.

Polymers
PS
Body Systems
Reproductive
Models
Mouse

Exposure to PS-NPs activated Bcl-2/Cleaved-caspase-2/Cleaved-caspase-3, leading to excessive apoptosis in human trophoblast cells and in mice placental tissues, further inducing miscarriage.

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