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20 resultsShowing papers similar to Uptake and toxicity of polystyrene micro/nanoplastics in gastric cells: Effects of particle size and surface functionalization
ClearNano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size
Researchers examined how different sizes of polystyrene nanoplastics affect human stomach cells in the laboratory. They found that smaller nanoplastics were more readily taken up by the cells and caused greater damage, including increased oxidative stress and reduced cell survival. The study suggests that nanoplastic particle size plays a critical role in determining their potential impact on gastrointestinal health.
Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period
Researchers systematically studied the effects of polystyrene micro- and nanoplastics on human liver cells, varying particle size, surface chemistry, concentration, and exposure duration. They found that smaller particles were internalized more readily and that surface functionalization significantly influenced toxicity, with aminated particles causing the most cell damage. The study suggests that particle characteristics beyond just size play an important role in determining how micro- and nanoplastics affect human cells.
Functionalized polystyrene nanoplastics induce distinct toxicity and transcriptomic changes in human intestinal Caco-2 cells
Researchers exposed human intestinal Caco-2 cells to polystyrene nanoplastics with different surface functionalizations (plain, aminated, carboxylated) and assessed cytotoxicity, cellular uptake, and transcriptomic responses. Surface chemistry strongly determined both uptake efficiency and the pattern of gene expression changes, with aminated particles inducing the most severe cytotoxic and inflammatory responses.
Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells
Researchers studied how human intestinal Caco-2 cells take up polystyrene plastic particles of five different sizes ranging from 300 nanometers to 6 micrometers. The study found that smaller particles were taken up at higher rates and that co-exposure with bisphenol A increased cellular toxicity, suggesting that nanoscale plastics may pose a greater risk to human intestinal cells than larger microplastics.
Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity
Researchers found that polystyrene microplastics accumulate mainly in stomach tissue, where smaller nanoscale particles cause more severe damage than larger ones. The nanoplastics reduced antioxidant enzyme activity, increased DNA damage markers, and activated signaling pathways associated with cancer development. These size-dependent effects on the gastrointestinal tract suggest that the smallest plastic particles may pose the greatest risk to digestive health.
Correlation between cellular uptake and cytotoxicity of polystyrene micro/nanoplastics in HeLa cells: A size-dependent matter
Researchers tested polystyrene particles of various sizes on human cells and found that only the smallest nanoplastics, those under about 25 nanometers in radius, could enter cells and cause toxic effects. Larger microplastic particles did not penetrate the cell membrane and showed no toxicity even at very high concentrations. The study provides a clear explanation for why smaller plastic particles tend to be more harmful, directly linking cell entry to cellular damage.
The potential effects of microplastic pollution on human digestive tract cells
Researchers tested polystyrene particles of four different sizes on human colon and small intestine cells to assess the potential effects of microplastic ingestion. They found that the smallest nanoscale particles were more readily taken up by cells and caused greater reductions in cell viability and increased oxidative stress. The study suggests that smaller plastic particles may pose a greater risk to the human digestive tract than larger ones.
Bioaccumulation of differently-sized polystyrene nanoplastics by human lung and intestine cells
Researchers examined how human lung and intestine cells take up polystyrene nanoplastics of different sizes, finding that smaller particles were internalized in greater numbers but at lower total mass compared to larger ones. When compared on a surface area basis, the uptake rates were similar across sizes, suggesting that surface interactions with cell membranes play a key role. The findings indicate that particle size is an important factor to consider when evaluating the health risks of nanoplastic exposure.
Cytotoxic effects of polystyrene nanoplastics with different surface functionalization on human HepG2 cells
Researchers exposed human liver (HepG2) cells to 50 nm polystyrene nanoparticles with three different surface chemistries and found that amino-functionalized particles caused the greatest cytotoxicity and oxidative stress, demonstrating that surface charge and chemistry — not just particle size — determine nanoplastic harm to human cells.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
Researchers compared the molecular mechanisms triggered by polystyrene nanoplastics with different surface functionalization in human colon cell lines. The study examined how surface chemistry of nanoplastic particles influences their biological interactions with intestinal cells, contributing to understanding of how nanoplastics may affect the human gastrointestinal system.
Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models
Researchers studied how the human digestive process transforms polystyrene microplastics and affects their intestinal toxicity using in vitro Caco-2 cell models. The study found that digestion formed a corona on microplastic surfaces without altering their chemical composition, and that smaller particles (100 nm) showed higher toxicity than larger ones (5 micrometers) regardless of digestive treatment.
Cellular interactions with polystyrene nanoplastics—The role of particle size and protein corona
Researchers investigated how polystyrene nanoplastics interact with mammalian cells, finding that particle size and the protein corona that forms around particles in biological fluids strongly influence cellular uptake and toxicity. Smaller nanoplastics penetrated cell membranes more readily and caused greater disruption, suggesting that the tiniest plastic particles may pose the greatest biological risk.
Cellular internalization and release of polystyrene microplastics and nanoplastics
Scientists studied how polystyrene plastic particles of different sizes enter and exit living cells. They found that particles 50 and 500 nanometers in size can penetrate cell membranes and get taken up through multiple pathways, while 5-micrometer particles are too large to enter cells. This research helps explain why smaller nanoplastics may be more harmful to human health, as they can more easily get inside our cells and accumulate there.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
Researchers compared molecular mechanisms triggered by differently functionalized micro- and nanoplastics in human cells, assessing how surface chemistry affects cellular responses. Surface functionalization significantly altered the toxicity profile of particles, with some coatings increasing and others decreasing inflammatory and oxidative responses.
Influence of the polymer type on the impact of microplastic particles
Researchers compared cellular toxicity of microparticles made from polystyrene, polyethylene, PVC, PLA, and cellulose acetate in murine macrophages and epithelial cells, finding that polymer type influences cytotoxicity and uptake behavior. All particle types were ingested by macrophages, but their surface chemistry and charge affected the degree of cellular damage.
Cellular absorption of polystyrene nanoplastics with different surface functionalization and the toxicity to RAW264.7 macrophage cells
Researchers tested how polystyrene nanoplastics with different surface coatings affect immune cells (macrophages) and found that positively charged amino-coated particles were the most toxic. All types of nanoplastics were absorbed into the cells, but the amino-coated ones caused the most cell membrane damage, oxidative stress, and cell death through a mitochondrial pathway. This matters because it shows that the surface chemistry of nanoplastics, not just their size, determines how dangerous they are to immune cells that serve as the body's first line of defense.
Are all nanoplastics equally neurotoxic? Influence of size and surface functionalization on the toxicity of polystyrene nanoplastics in human neuronal cells
Researchers tested four types of polystyrene nanoplastics on human neuronal cells and found that toxicity varied dramatically depending on particle surface chemistry. Particles with amine surface groups were the most harmful, significantly reducing cell survival and causing visible damage to cell structures, while unmodified particles showed minimal toxicity, suggesting that surface properties matter as much as size when assessing nanoplastic risks.
Effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles
Researchers studied the effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles. The study suggests that environmental weathering can alter how micro- and nanoplastics interact with biological systems, with potential implications for understanding human health effects from ingested plastic particles.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
Researchers compared molecular and cellular mechanisms triggered by differently surface-functionalized micro- and nanoplastics in human intestinal and liver cells, finding that surface chemistry strongly determines biological effects. Functionalized particles elicited distinct patterns of oxidative stress, inflammation, and membrane damage compared to unfunctionalized particles.
The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
Researchers studied how the human digestive process changes the physical and biological properties of polystyrene nanoplastics. They found that digestive fluids altered the surface characteristics of the particles, potentially affecting how they interact with gut cells. The study suggests that the form of nanoplastics that actually reaches our intestines may behave differently than the pristine particles typically used in lab studies.