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61,005 resultsShowing papers similar to Potential effects of MPs and their co-pollutants on human intestinal tract
ClearMicro(nano)plastics in food system: potential health impacts on human intestinal system.
This review assessed how micro(nano)plastics in the human food system reach the intestine and accumulate in the gut, summarizing evidence that they can alter intestinal barrier function, trigger inflammation, and disrupt the gut microbiome, with implications for long-term digestive health.
Micro(nano)plastics and their potential impact on human gut health: a narrative review
This narrative review synthesizes evidence on how microplastics and nanoplastics affect the human gut, discussing ingestion routes, gut barrier interactions, microbiome disruption, and potential systemic health effects.
Gut microbiota as an emerging target for the health implications of microplastics
This review examines how microplastic exposure disrupts the gut microbiome, finding evidence that microplastics damage intestinal barrier proteins, promote inflammation and oxidative stress, and may drive systemic effects including neurotoxicity and reproductive toxicity through gut-mediated pathways.
Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review
This review summarizes research on how micro- and nanoplastics affect the gut, finding that they can damage the intestinal lining, trigger immune responses, and disrupt the balance of beneficial gut bacteria in both cell studies and animal models. Since humans are primarily exposed to microplastics through food and food packaging, understanding these gut effects is essential for assessing the true health risks of plastic pollution.
Trojan horse in the intestine: A review on the biotoxicity of microplastics combined environmental contaminants
This review examines how microplastics act as 'Trojan horses' by carrying other environmental contaminants such as heavy metals, persistent organic pollutants, and pathogens into the intestinal system. Researchers analyzed the mechanisms by which microplastics adsorb and release these co-contaminants and how the combinations affect the gut barrier. The study highlights that the interactive toxicity of microplastics with other pollutants may be more harmful than either pollutant alone, particularly to intestinal health.
Microplastics and the gut microbiome: Emerging health concerns and strategies
This review covers how microplastic ingestion affects the gut microbiome, describing mechanisms by which microplastics cause intestinal disorders, disrupt endocrine function, and promote pathogenic bacterial growth, while also noting inhalation and dermal absorption as secondary exposure routes.
Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment
This review summarizes current research on how microplastics disrupt the gut environment in both animals and humans, focusing on damage to the intestinal barrier. Studies show that microplastic exposure can cause oxidative damage, inflammation, destruction of the gut lining, thinning of the protective mucus layer, and disruption of beneficial gut bacteria. While direct human evidence is still limited, the growing body of animal research suggests that microplastics could pose a meaningful threat to intestinal health.
Human Exposure to Microplastics and Its Associated Health Risks
This review examines how microplastics enter the human body through food, air, and skin, and have been detected in stool, blood, and tissues. Research in lab animals and human cells shows that microplastics can disrupt digestion, immunity, the nervous system, and reproduction, and can also amplify the toxicity of other environmental pollutants they carry.
Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
This review examines the evidence on how nano- and microplastics affect the immune system and intestinal health. The findings suggest that exposure to these particles can disrupt the gut microbiome and impair critical intestinal barrier functions, potentially contributing to the development of chronic inflammatory and immune conditions.
The infiltration of microplastics in human systems: Gastrointestinal accumulation and pathogenic impacts
This review focuses on how microplastics accumulate in the human digestive system and what health problems they might cause. The authors explain that people ingest microplastics through food, water, and air, and these particles may trigger inflammation, disrupt gut bacteria, and potentially contribute to gastrointestinal diseases.
Toxicological Evaluation of Effects of Some Environmental Pollutants on Intestinal Microbiota: Traditional Review
This review examines how various environmental pollutants affect the gut microbiome — the community of microorganisms in the intestinal tract. Microplastics are among the pollutants discussed, and their ability to alter gut microbiota composition is increasingly recognized as a mechanism by which plastic particles may harm human and animal health.
The role of gut microbiota in MP/NP-induced toxicity
This review summarizes how micro- and nanoplastics disrupt gut bacteria and why that matters for overall health. The tiny plastic particles change the composition and function of the gut microbiome, which can trigger inflammation, weaken the intestinal barrier, and potentially contribute to diseases beyond the gut through the immune and nervous systems.
[Effect of microand nanoplastics on the gastrointestinal mucosa and intestinal microbiome].
This review examines how micro- and nanoplastics entering through the food chain affect the gastrointestinal tract, finding evidence of disruption to gut mucosal integrity and intestinal microbiome composition, with implications for digestive health and systemic immune function.
Research Advances on the Impact of Environmental Pollutants on Gut Microbiota
This review synthesizes evidence from animal models, human studies, and mechanistic experiments showing how microplastics, pesticides, and heavy metals each disrupt gut microbiota composition, reduce beneficial bacteria, and compromise intestinal barrier integrity and host health.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Developments in the field of intestinal toxicity and signaling pathways associated with rodent exposure to micro(nano)plastics.
This review synthesizes current research on how micro- and nano-plastics damage the intestinal epithelium, disrupt gut barrier function, and activate inflammatory signaling pathways. The findings highlight the gut as a primary site of microplastic accumulation and suggest that intestinal toxicity may link dietary microplastic exposure to systemic health effects.
Impacts of microplastics on gut health: Current status and future directions
This systematic review found consistent evidence across mouse, fish, and earthworm models that microplastics disrupt gut microbiota composition, impair intestinal barrier integrity, and trigger gastrointestinal inflammation. The correlation between microplastic exposure and gut health deterioration was statistically significant across all animal models examined.
The whole life journey and destination of microplastics: A review
This review traces the full journey of microplastics from their environmental sources through their various pathways into the human body, and what happens once they get inside. Once ingested, microplastics can disrupt gut bacteria, damage the intestinal barrier, and then spread to other organs where they cause inflammation and toxicity. The review highlights significant gaps in our understanding and emphasizes the need for more research on how microplastics move through the body and accumulate over time.
A Comprehensive Narrative Review of Potential Gastrointestinal Adverse Effects From Micro(nano) Plastic Exposure
This narrative review synthesizes evidence on gastrointestinal adverse effects of micro- and nanoplastic exposure, examining how these particles interact with gut microbiota, mucosal barriers, and immune tissue to contribute to inflammatory bowel disease, liver disease, and colorectal cancer risk.
Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction
Researchers investigated how micro- and nanoplastics disrupt gut barrier function in mice, finding that different surface chemistries caused varying levels of damage. The study suggests that these plastic particles harm the gut by altering the gut microbiome, which then leads to inflammation and weakening of the intestinal barrier that normally keeps harmful substances out of the body.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review provides the first comprehensive look at how microplastics and nanoplastics affect the human gut using laboratory models. The findings help explain how these tiny particles may damage the digestive tract lining and trigger inflammation, which is important for understanding the health risks of swallowing microplastics in food and water.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review of 30 in vitro studies found that microplastics and nanoplastics cause size- and concentration-dependent damage to human gastrointestinal cells, including increased oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Smaller particles consistently showed greater cellular uptake and biological effects, though chronic low-dose exposure generally produced minimal impacts.
Microplastics in humans: Current evidence of presence and their role in organ toxicity
This comprehensive review examined how microplastics enter the human body through ingestion, inhalation, dermal absorption, and maternal-fetal transfer, summarizing documented evidence of MP presence and toxic effects across multiple organs.
Microplastics (MPs): Fate in in vitro human digestive environment and study of the dialogue between epithelium, microbiota and mucus
This study examined what happens to microplastics as they pass through the human digestive system in vitro, studying interactions between plastic particles, gut microbiota, and intestinal mucus. Understanding how the gut processes microplastics is a key step in evaluating their potential health effects.