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20 resultsShowing papers similar to Maternal and early life exposures and their potential to influence development of the microbiome
ClearInfant microbiota formation: mother – placenta – fetus – baby
This review examines how infant gut microbiota forms through the mother-placenta-fetus-baby pathway, with colonization beginning during the prenatal period. The study discusses how factors such as delivery mode, breastfeeding, and maternal health shape early microbial communities that influence long-term health outcomes.
Resilience to Global Health Challenges Through Nutritional Gut Microbiome Modulation
This review explores how gut microbiome composition during early life influences long-term health, and how nutritional strategies can help build resilience against chronic diseases. Researchers highlight that environmental factors including microplastics and other contaminants can disrupt the developing gut microbiome, potentially contributing to allergies, obesity, and neurological conditions. The study suggests that targeted nutritional interventions to support healthy gut bacteria could help counteract some of these environmental exposures.
Microplastics Versus Microbiome: The Infantile Gut’s Battle for Health
This review examines how microplastics and nanoplastics disrupt the developing gut microbiome in infants, covering potential effects on microbial stabilization, antibiotic resistance gene transfer through biofilm formation, and implications for long-term metabolic and immune health.
Impact of Environmental Exposure on Infant Sleep : The Exposome Approach
This review synthesizes evidence on how environmental chemical exposures affect infant sleep outcomes, with a focus on the first 1,000 days of life. Researchers examined how infants may be exposed to pollutants including microplastics before birth through the placenta or after birth through diet and the environment. The study highlights the need for more research into how these early-life environmental exposures may disrupt sleep, which is critical for infant development.
Interactions between gut microbiota and emerging contaminants exposure: new and profound implications for human health
This review explores how emerging contaminants like microplastics, antibiotics, and persistent organic pollutants interact with gut bacteria and what that means for human health. Researchers found that the gut microbiome is a key target of these pollutants and may play a role in organ damage, hormonal disruption, and other toxic effects through pathways like the gut-liver and gut-brain axes. The study underscores the importance of understanding the three-way relationship between environmental contaminants, gut bacteria, and overall health.
Current knowledge on the effects of environmental contaminants in early life nutrition
This review examines how environmental contaminants, including microplastics and endocrine-disrupting chemicals, can enter infant diets through breast milk, formula, and early solid foods. Researchers found that these pollutants transfer into breast milk through passive diffusion and can also leach from bottles, packaging, and food contact materials. The study emphasizes the need for better monitoring and regulation to protect infants during this critical developmental window.
Deciphering the Role of the Gut Microbiota in Exposure to Emerging Contaminants and Diabetes: A Review
This review explores the connection between exposure to emerging environmental contaminants, including microplastics and nanoplastics, and disruptions to gut microbiota that may influence glucose metabolism and diabetes risk. Researchers found that these pollutants can alter the composition and function of gut microbial communities through multiple mechanisms. The study suggests that the gut microbiome may be a key pathway through which environmental contaminants affect metabolic health.
Polystyrene Microplastics Disrupt Vertical Transmission of the Breast Milk Microbiome, Impairing Early‐Life Gut Colonization and Immune Development in Offspring
Researchers exposed pregnant and lactating mice to polystyrene microplastics and found that maternal exposure disrupted the breast milk microbiome, reducing beneficial bacteria like Ligilactobacillus while increasing potentially harmful ones. Offspring from exposed mothers showed altered gut colonization, excessive weight gain, reduced immune markers, and compromised intestinal barrier integrity, suggesting microplastics may affect infant development through changes in breast milk composition.
The Association Between Microplastics and Microbiota in Placentas and Meconium: The First Evidence in Humans
Researchers analyzed placentas and meconium from 18 mother-infant pairs in Shanghai and found microplastics present in both, providing some of the first direct evidence of microplastic exposure during pregnancy and at birth. They also discovered correlations between microplastic presence and changes in microbial communities in these tissues. The study raises important questions about whether early-life microplastic exposure could influence infant health and development.
Toxicological Evaluation of Effects of Some Environmental Pollutants on Intestinal Microbiota: Traditional Review
This review examines how various environmental pollutants affect the gut microbiome — the community of microorganisms in the intestinal tract. Microplastics are among the pollutants discussed, and their ability to alter gut microbiota composition is increasingly recognized as a mechanism by which plastic particles may harm human and animal health.
The Footprint of Microbiome in Pediatric Asthma—A Complex Puzzle for a Balanced Development
This review examines the growing body of evidence linking the human microbiome to the development of pediatric asthma. Researchers found that the composition of bacteria in the gut and respiratory tract during early childhood appears to influence whether children develop asthma. The study suggests that understanding these microbial patterns could open new approaches for preventing or managing asthma in children.
Effects of Environmental Exposure on Host and Microbial Metabolism
This collection of studies investigates how environmental exposures, including microplastics, PFAS, and other emerging pollutants, disrupt the gut microbiota and alter host metabolism. The research covers a wide spectrum of contaminants and examines how they affect the trillions of microorganisms in the gastrointestinal tract that play essential roles in human health. The findings suggest that environmental pollutants can drive metabolic changes by disrupting the balance between gut microbes and their human hosts.
Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study
Researchers reviewed 69 studies and conducted a cohort study to understand what shapes the gut microbiome of newborns at birth, finding that conditions during delivery — such as cesarean section versus vaginal birth — have a much stronger influence on early microbiota than factors during pregnancy. This suggests the initial seeding of a baby's gut microbiome happens mainly during the birth process itself.
Associations of Plastic Bottle Exposure with Infant Fecal Microbiota, Short-Chain Fatty Acids, and Growth
Researchers investigated associations between plastic bottle use and infant gut health, examining whether exposure influences early fecal microbiota composition, short-chain fatty acid levels, and growth trajectories in infants.
Beyond Infections: Exploring Immune-Mediated Pathways Linking Cannabis and Emerging Environmental Contaminants to Neurodevelopmental Outcomes
This review explores how prenatal exposure to cannabis and emerging environmental contaminants, including micro- and nanoplastics, may affect fetal brain development through immune-mediated pathways. Researchers found that these exposures can disrupt the delicate immune balance between mother and fetus, potentially increasing the risk of neurodevelopmental conditions. The study highlights the need for more research into how environmental pollutants interact with substance exposure to affect brain development before birth.
Contaminants of emerging concern in the fetal environment
This review examines how pregnant women are exposed to a broad spectrum of environmental contaminants including endocrine-disrupting compounds and emerging pollutants such as microplastics that can cross the placenta and reach the developing fetus. The review highlights that prenatal exposure to these contaminants can interfere with hormonally driven developmental processes and may predispose the fetus to disease later in life.
Relevance of gut microbiome research in food safety assessment
This review examines evidence that food additives and microplastics may disrupt the gut microbiome and, in turn, affect human health. The researchers discuss how these non-nutritive dietary compounds can alter gut bacterial communities through mechanisms that are often overlooked in food safety evaluations. They recommend integrating gut microbiome science into food risk assessment frameworks to better protect human health.
Research Advances on the Impact of Environmental Pollutants on Gut Microbiota
This review synthesizes evidence from animal models, human studies, and mechanistic experiments showing how microplastics, pesticides, and heavy metals each disrupt gut microbiota composition, reduce beneficial bacteria, and compromise intestinal barrier integrity and host health.
Microplastics and their interactions with microbiota
This review examines how microplastics interact with microbiota (the communities of microorganisms in the environment and in living bodies). Microplastics can carry harmful bacteria and disrupt the natural balance of microbial communities in soil, water, and the human gut. The disruption of gut microbiota by microplastics is particularly concerning because a healthy gut microbiome is essential for immune function, digestion, and overall health.
Micro problems with macro consequences: accumulation of persistent organic pollutants and microplastics in human breast milk and in human milk substitutes
This review examines the presence of persistent organic pollutants and microplastics in both human breast milk and infant formula, raising questions about early-life exposure. Researchers found that these contaminants can transfer to infants during the critical first 1,000 days of development, a period important for long-term health. The study highlights significant gaps in our understanding of how combined exposure to microplastics and organic pollutants during infancy may affect health outcomes.