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Papers
61,005 resultsShowing papers similar to Novel application of microparticles demonstrate myeloid uptake and induce phenotypic change within the brain tumor microenvironment 2254
ClearA Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells
This study developed nanoparticle-based technology to treat aggressive brain tumors (glioblastoma) by penetrating deep into tumor tissue and activating the immune system against cancer cells. While not directly about microplastic pollution, it demonstrates that nanoparticles can cross brain barriers and influence immune responses. The research is relevant because it shows how tiny particles, including plastics, can access and affect the brain.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.
Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle.
This study tested polymer microparticles as a delivery system for a cancer drug in brain tumor models. This is a drug delivery and cancer treatment research paper with no direct connection to environmental microplastics.
Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
Researchers developed a nanoparticle-based treatment that combines microwave energy, chemotherapy, and immune activation to reverse the protective environment that tumors create to hide from the immune system. In animal experiments, this combined approach significantly increased immune cell infiltration into tumors and improved the body's ability to fight cancer beyond the treated area.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations
Researchers reviewed how nanoparticles embedded in hydrogels — water-based gel materials — can serve as targeted drug delivery vehicles for brain tumors by crossing the blood-brain barrier, a major obstacle that blocks most medications from reaching the brain. These systems have shown improved survival rates in studies, and the review outlines remaining challenges around manufacturing, stability, and scaling up for clinical use.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Role of microplastics in the tumor microenvironment (Review)
This review examines how microplastics may help tumors grow by influencing the environment around cancer cells. Microplastics can interact with immune cells, connective tissue cells, blood vessel cells, and the tissue scaffolding around tumors in ways that may promote cancer progression and inflammation. While more research is needed, the findings raise important questions about whether chronic microplastic exposure could affect cancer development in humans.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
The Immunotoxic Effects of Environmentally Relevant Micro- and Nanoplastics
Researchers characterized the immunotoxic effects of over 20 types of micro- and nanoplastic particles on macrophages and dendritic cells, finding that physicochemical properties such as size, shape, polymer type, and surface oxidation strongly influence immune cell responses.
Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo
Researchers found that polystyrene microplastics can cross the blood-brain barrier in mice after oral exposure and accumulate in brain tissue, where they are engulfed by microglia, the brain's immune cells. This engulfment triggered inflammatory responses and cell death in the microglia both in cell cultures and in living mice. The study suggests that microplastic exposure may affect brain immune function, with potential implications for neurological health.
A quantitative study of nanoplastics within cells using magnetic resonance imaging
Researchers developed a magnetic resonance imaging strategy to quantify nanoplastics internalized by mouse macrophage cells, providing a novel non-invasive approach for tracking nanoplastic uptake and distribution within living organisms.
Microplastics and Their Effect on Neuroglia: A Narrative Review
This narrative review examines how microplastics — entering the body through inhalation, ingestion, and skin contact — may accumulate in neuroglial cells of the brain, raising concern about their role in neuroinflammation and neurodegenerative disease progression.
Nanoplastics Shape Adaptive Anticancer Immunity in the Colon in Mice
In a mouse study, researchers found that orally administered polyethylene nanoplastics disrupted the intestinal immune environment in ways that could favor tumor growth in the colon. The nanoplastics altered immune cell populations and promoted an immunosuppressive environment around colorectal tumors. The study suggests that nanoplastic exposure may influence how the immune system responds to abnormal cell growth in the gut.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.
Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4
Researchers discovered that glioblastoma brain tumor cells produce structures called migrasomes that release proteins into surrounding tissue, helping the cancer spread more aggressively. Blocking formation of these migrasomes significantly reduced tumor cell migration and invasion, identifying new potential targets for treating this deadly brain cancer.
Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin
This paper discusses the prevalence of micro- and nanoplastics and the health concerns they raise, particularly noting that nanoplastics are believed to be more toxic because they can pass through biological barriers. A key challenge is developing reliable detection methods for particles smaller than 1 micrometer.
The nervous system is the major target for Gold nanoparticles: Evidence from RNA sequencing data of C. elegans
This review examines research suggesting that the nervous system is a primary target for gold nanoparticle toxicity, with evidence from animal models showing that these particles cross the blood-brain barrier and accumulate in neural tissue. While focused on gold nanoparticles, the findings are relevant to understanding how nanoplastics may also affect the brain.
Primary astrocytes as a cellular depot of polystyrene nanoparticles
Researchers found that astrocytes — support cells in the brain — absorb polystyrene nanoplastics far more efficiently than neurons and act as a cellular buffer to protect nerve cells, but become overactivated when the particle load is too high, losing their protective function and potentially contributing to neurological harm.
Nanoparticles in Drug Delivery
This review examines how nanoparticles made from various materials, including polymers, are being developed for targeted drug delivery across biological barriers. Researchers highlighted advances in stimuli-responsive nanoparticle engineering for tumor targeting and the integration of AI models for personalized medicine. While focused on biomedical applications, the study is relevant to understanding how polymer-based particles interact with biological systems at the nanoscale.
A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation
Researchers developed a microfluidic blood-brain barrier model using human endothelial cells, astrocytes, and pericytes to compare nanoparticle transport, finding that extracellular vesicles crossed most efficiently and that ligand presentation and membrane composition — not size or stiffness — were the primary determinants of barrier penetration.
Morphological and lipid metabolism alterations in macrophages exposed to model environmental nanoplastics traced by high-resolution synchrotron techniques
Researchers used advanced imaging techniques to study how nanoplastics affect immune cells called macrophages and found that the particles caused significant changes in cell shape and disrupted fat metabolism. The nanoplastics accumulated inside the cells and altered the composition and distribution of lipids, which are essential for normal immune function. The findings suggest that nanoplastic exposure may impair the immune system by interfering with how immune cells process and store fats.
Application of Hydrogel as Drug Carrier in Tumor Therapy
This review summarizes recent advances in hydrogel-based drug delivery systems for cancer therapy, focusing on their ability to achieve controlled drug release and respond to tumor microenvironment signals for targeted treatment.