Papers

61,005 results
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Article Tier 2

Protective effect of Spirulina in the ovary of rats against Doxorubicin toxicity

This experimental study examined whether Spirulina supplementation could protect rat ovaries from toxicity caused by doxorubicin, an anti-cancer agent known to cause reproductive side effects. Spirulina's antioxidant phytopigments including beta-carotene and tocopherols were found to reduce Dox-induced reproductive toxicity in ovarian tissue.

2024 Revista Científica de la Facultad de Ciencias Veterinarias 1 citations
Article Tier 2

Protective Effect of Chlorella vulgaris and Spirulina platensis against ThioacetamideInduced Hepatorenal Toxicity in Male Rats

This paper is not directly about microplastics — it evaluates whether the microalgae Chlorella vulgaris and Spirulina platensis can protect against liver and kidney toxicity caused by thioacetamide in rats, finding significant protective effects via antioxidant mechanisms.

2023 Journal of Current Veterinary Research 2 citations
Article Tier 2

The Impact of Microalgae and Their Bioactive Compounds on Liver Well-being in Rats Subjected to Synthetic Phenolic Antioxidants

This review examines how microalgae and their bioactive compounds — including polysaccharides, pigments, and polyphenols — protect liver health in animal models, summarizing evidence for anti-inflammatory and antioxidant mechanisms. The authors note that algal-derived compounds show hepatoprotective effects in rodent studies, though human clinical evidence remains limited.

2024 Egyptian Journal of Veterinary Science
Article Tier 2

The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)

Researchers investigated whether Spirulina algae supplementation could protect Nile tilapia fish from blood toxicity caused by gibberellic acid, a plant growth hormone widely used in agriculture that contaminates nearby waterways. Fish fed higher doses of Spirulina showed near-normal blood cell counts and reduced DNA damage after exposure, suggesting the algae has protective antioxidant properties that could help organisms cope with agricultural chemical contamination.

2022 Environmental Science and Pollution Research 24 citations
Article Tier 2

Antioxidative Responses of Chlorella vulgaris Under Different Growth Phases

Researchers tracked the antioxidant enzyme activity and non-enzymatic antioxidant production of Chlorella vulgaris microalgae across all growth phases, documenting how the organism's natural antioxidant capacity varies throughout its life cycle.

2022 SQUALEN Bulletin of Marine and Fisheries Postharvest and Biotechnology 6 citations
Article Tier 2

Recent progress on the toxic effects of microplastics on Chlorella sp. in aquatic environments

This review summarizes research on how microplastics affect Chlorella, a type of green algae that forms the base of aquatic food chains. Microplastics can slow algae growth, cause oxidative stress, and disrupt photosynthesis, which matters for human health because damage to these foundational organisms can ripple up through the food web and affect the quality of water and seafood.

2024 Heliyon 39 citations
Article Tier 2

Dietary Arthrospira platensis in Rainbow Trout (Oncorhynchus mykiss): A Means to Reduce Threats Caused by CdCl2 Exposure?

Researchers investigated whether dietary Spirulina supplementation could protect rainbow trout from cadmium chloride toxicity, evaluating growth performance, immune response, and tissue damage to assess its potential as a protective feed additive in aquaculture.

2022 Toxics 32 citations
Article Tier 2

Chlorella alleviates the intestinal damage of tilapia caused by microplastics

Researchers investigated how polyethylene microplastics of different sizes affect the intestinal health of tilapia and whether Chlorella algae supplementation could alleviate the damage. They found that microplastics caused intestinal histological changes and disrupted enzyme activities, gene expression, and gut microbiota in the fish. The addition of Chlorella showed potential to mitigate some of the intestinal damage caused by nanoscale microplastic exposure.

2024 Chemosphere 12 citations
Article Tier 2

Impact of Natural Microorganisms on the Removal of COD and the Cells Activity of the Chlorella sp. in Wastewater

This is not a microplastics study; it examines how adding natural microorganisms to a Chlorella algae system maintains algal cell activity and improves chemical oxygen demand removal in wastewater treatment.

2023 Water 6 citations
Article Tier 2

Spotlight on the long-term effects of micro/nanoplastics exposure on Spirulina platensis: Algal cells, extracellular polymeric substances, and phycocyanin

Scientists studied the effects of micro and nanoplastics on Spirulina, a nutritional algae widely used as a food supplement, over a 50-day period. The plastic particles slowed Spirulina growth, damaged cell surfaces, and initially reduced the quality and quantity of phycocyanin, a valuable blue pigment. Since Spirulina is consumed by humans as a health food, microplastic contamination in algae culture environments could affect the quality and safety of these supplements.

2025 Food Chemistry 6 citations
Article Tier 2

Selenium-containing polysaccharide from Spirulina platensis alleviates Cd-induced toxicity in mice by inhibiting liver inflammation mediated by gut microbiota

Researchers found that selenium-containing polysaccharide from Spirulina platensis alleviates cadmium-induced liver toxicity in mice by modulating gut microbiota composition and suppressing inflammatory pathways, suggesting a protective role against heavy metal exposure.

2022 Frontiers in Nutrition 25 citations
Article Tier 2

Evaluation of valoneic acid and the cytostasis properties of lagerstroemia speciosa ethanolic leaf extract on the accumulation of MPS in the complete blood count of the albino rats

Researchers evaluated valoneic acid from Lagerstroemia speciosa leaf extract for its potential to mitigate the effects of microplastic accumulation on blood parameters in albino rats exposed to microbeads and glyphosate. The study explores medicinal plant compounds as protective agents against microplastic and pesticide-associated hematotoxicity.

2024 World Journal of Advanced Research and Reviews
Article Tier 2

Spirulina platensis supplementation remediates microplastics-induced growth inhibition and stress in Nile tilapia, Oreochromis niloticus

Nile tilapia fish exposed to microplastics showed reduced growth, intestinal damage, and signs of immune stress, but adding the dietary supplement Spirulina to their feed significantly reversed these harmful effects. Spirulina reduced oxidative stress and helped repair gut damage caused by microplastic exposure. While this is a fish study, it suggests that certain natural supplements might help protect against some of the biological damage caused by microplastic ingestion.

2025 Journal of Hazardous Materials Advances 5 citations
Article Tier 2

Investigation of the toxic effects of different polystyrene micro-and nanoplastics on microalgae Chlorella vulgaris by analysis of cell viability, pigment content, oxidative stress and ultrastructural changes

Researchers examined the toxic effects of different-sized polystyrene micro- and nanoplastics on the microalga Chlorella vulgaris in long-term exposure tests. The study found that smaller particles (20 and 50 nm) caused greater reductions in cell viability and chlorophyll concentration than larger ones, with surface functionalization also influencing toxicity and ultrastructural damage.

2020 Marine Pollution Bulletin 209 citations
Article Tier 2

Evaluation of Chlorella vulgaris biosorption capacity for phosphate and nitrate removal from wastewater

Researchers found that the common green microalgae Chlorella vulgaris can effectively remove phosphate and nitrate from wastewater through a natural adsorption process, with optimal removal at neutral pH and 24-hour contact time — offering a low-cost, environmentally friendly alternative to chemical water treatment.

2024 Scientific Reports 17 citations
Article Tier 2

Toxicity of Tetracycline and Metronidazole in Chlorella pyrenoidosa

Researchers studied the individual and combined toxicity of the antibiotics tetracycline and metronidazole on the green alga Chlorella pyrenoidosa. The study found that tetracycline was more toxic than metronidazole, and when combined, the two antibiotics had a synergistic effect that increased damage to algal cell membranes, morphology, and oxidative stress responses.

2023 International Journal of Environmental Research and Public Health 29 citations
Article Tier 2

Concentration dependent toxicity of microplastics to marine microalgae

Researchers exposed the marine microalga Chlorella sp. to polystyrene microplastics at concentrations of 10 and 50 mg/L, finding that even low concentrations inhibited growth and disrupted photosynthesis, while higher concentrations caused more pronounced oxidative stress.

2025 E3S Web of Conferences
Article Tier 2

Effect of microplastics and microplastic-metal combinations on growth and chlorophyll a concentration of Chlorella vulgaris

Researchers tested the effects of polystyrene microplastics alone and in combination with metals (copper, zinc, manganese) on the freshwater microalga Chlorella vulgaris. The study found that low microplastic concentrations had no significant impact, but higher concentrations reduced algal growth and chlorophyll content, with metal-microplastic combinations producing more pronounced effects.

2020 The Science of The Total Environment 231 citations
Article Tier 2

Influence of microplastics on microalgal performance during wastewater polishing

Researchers studied how five common types of microplastics affect the green alga Chlorella vulgaris during wastewater treatment. They found that while microplastics reduced algal metabolism and growth, the organism maintained its ability to effectively remove nutrients from wastewater. The study demonstrates that Chlorella vulgaris is a robust candidate for bioremediation of microplastic-contaminated wastewater, even under pollutant stress.

2026 Journal of Environmental Sciences
Article Tier 2

Investigating the protective effects of epigallocatechin-gallate against polystyrene microplastics-induced biochemical and hematological alterations in rats

This study investigated whether epigallocatechin-gallate (EGCG) -- a green tea antioxidant -- could protect rats from biochemical and hematological damage caused by polystyrene microplastic ingestion. EGCG supplementation partially mitigated oxidative stress and inflammatory markers elevated by polystyrene microplastic exposure, suggesting a potential dietary protective strategy.

2024 Clinical Traditional Medicine and Pharmacology 1 citations
Article Tier 2

Impact of Chlorella vulgaris Bioremediation and Selenium on Genotoxicity, Nephrotoxicity and Oxidative/Antioxidant Imbalance Induced by Polystyrene Nanoplastics in African Catfish (Clarias gariepinus)

Researchers found that polystyrene nanoplastics caused DNA damage, kidney injury, and oxidative stress in African catfish. The study suggests that treatment with the green algae Chlorella vulgaris and the mineral selenium helped reduce these harmful effects, pointing to potential protective strategies against nanoplastic toxicity in aquaculture.

2024 Preprints.org 4 citations
Article Tier 2

Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)

Researchers fed albino rats different concentrations of microplastics for 28 days and measured changes in blood, liver, kidney, and lipid profiles. They found dose-dependent effects including reduced immune cell counts suggesting immunosuppression, lower red blood cell levels indicating anemia, and altered liver and kidney function markers. The study provides evidence that microplastic ingestion may affect multiple organ systems and blood health in a way that worsens with higher exposure levels.

2024 Environmental Analysis Health and Toxicology 8 citations
Article Tier 2

Effects of Combination Treatments with Astaxanthin-Loaded Microparticles and Pentoxifylline on Intracellular ROS and Radiosensitivity of J774A.1 Macrophages.

This study examined how astaxanthin-loaded microparticles combined with a drug affected reactive oxygen species levels and radiation sensitivity in immune cells. This is a cancer treatment research study with no direct connection to environmental microplastics.

2021 Molecules (Basel, Switzerland)
Article Tier 2

Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats

Not relevant to microplastics — this is a pharmacological study testing whether caffeine and vitamin C can correct blood disorders (anemia, low white blood cells, low platelets) induced by heparin, phenylhydrazine, and aspirin in laboratory rats.

2023 International Journal of Science and Research Archive