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The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats
Summary
Researchers found that oral supplementation of Spirulina platensis or Chlorella vulgaris before and after whole-body gamma irradiation significantly attenuated radiation-induced decreases in red and white blood cell counts, hemoglobin, and platelets, and reduced liver enzyme elevation in male albino rats. The results suggest both microalgae may offer protective effects against radiation-induced hematological and organ damage.
Background: Patients undergoing radiotherapy may suffer from many harmful effects including gut microbiota injury, therefore, the use of exogenous probiotics is suggested to reduce these effects. Aim: The present study aimed to determine the possible protective effect of Spirulina platensis and Chlorella vulgaris against radiation-induced hematological and biochemical disturbances in male albino rats. Materials and Methods: Spirulina or chlorella was administered orally at a dose level of 300 mg/kg body weight daily for one week before and one week after the exposure to gamma radiation (6Gy, single dose). Results: Whole-body gamma-irradiation induced a significant decrease in total leukocyte count, red blood cell count, hemoglobin concentration, hematocrit value and platelets count, compared to their corresponding values of the control group. A significant increase in alanine aminotransferase (ALT) activity, marker of liver damage, and a non-significant increase in urea and creatinine levels, markers of kidney function was is observed. Spirulina or chlorella administration pre- and post-irradiation has significantly attenuated the radiation-induced disturbances in the studied parameters. Conclusion: oral supplementation of spirulina or chlorella may afford protection against radiation-induced detrimental effect and may preserve the tissue integrity and the functions of different organs in the body.
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