Papers

61,005 results
|
Article Tier 2

Antioxidant Capacity, Enzyme Activities Related to Energy Metabolism, and Transcriptome Analysis of Crassostrea hongkongensis Exposed to Hypoxia

Researchers studied how low-oxygen conditions affect the antioxidant defenses and energy metabolism of the Hong Kong oyster, an important aquaculture species in China. They found that hypoxia significantly altered enzyme activity related to energy production and caused oxidative stress in the oysters. The study provides insights into how seasonal oxygen depletion in coastal waters threatens oyster health and aquaculture productivity.

2024 Antioxidants 5 citations
Article Tier 2

Genome-wide identification of seven superoxide dismutase genes in the marine rotifer Brachionus rotundiformis and modulated expression and enzymatic activity in response to microplastics and nutritional status

All superoxide dismutase genes in the marine rotifer Brachionus rotundiformis were identified and characterized, with expression and enzymatic activity showing complex modulation in response to microplastic exposure under both normal feeding and starvation conditions.

2021 Aquatic Toxicology 10 citations
Article Tier 2

The Combined Effects of Toxic Microcystis aeruginosa and Thermal Stress on the Edible Clam (Corbicula fluminea): Insights into Oxidative Stress Responses and Molecular Networks

Researchers exposed the edible clam Corbicula fluminea to combined thermal stress and toxic Microcystis aeruginosa cyanobacteria, finding that the combined stressors caused greater oxidative stress and physiological disruption than either alone, with implications for bivalve aquaculture during cyanobacterial bloom events.

2023 Antioxidants 3 citations
Article Tier 2

Determination of bioaccumulation of polystyrene nanoplastics in mussel Mytilus galloprovincialis and their impact on enzymatic and nonenzymatic antioxidative stress mechanisms

Researchers assessed the bioaccumulation of polystyrene nanoplastics in the mussel Mytilus galloprovincialis and measured enzymatic and non-enzymatic antioxidant stress responses after 4 days of exposure to 1 mg/L of 54 nm particles. Nanoplastics accumulated in mussel tissues and triggered significant oxidative stress responses, including altered superoxide dismutase and catalase activity, indicating toxicological effects at environmentally relevant concentrations.

2024 Juraj Dobrila University of Pula Digital Repository
Article Tier 2

Exposure to plastic debris alters expression of biomineralization, immune, and stress-related genes in the eastern oyster (Crassostrea virginica)

Researchers exposed eastern oysters to plastic debris during their first year of life and then analyzed changes in gene activity using RNA sequencing. They found that plastic exposure altered the expression of genes involved in shell building, immune response, and stress management. The study suggests that chronic contact with degrading plastics in the ocean can disrupt multiple biological processes in shellfish.

2025 PLoS ONE 4 citations
Article Tier 2

Environmental and Sublethal Concentrations of Polystyrene Nanoplastics Induced Antioxidant System, Transcriptomic Responses, and Disturbed Gut Microbiota in Oyster Magallana Hongkongensis

Researchers exposed Hong Kong oysters to polystyrene nanoplastics at both environmentally realistic and higher concentrations. Even at the lower, real-world concentrations, the nanoplastics significantly altered the oysters' gut bacteria and gene expression patterns, while higher doses also triggered immune and antioxidant stress responses, raising concerns about food safety and ecosystem health.

2024 Journal of Agricultural and Food Chemistry 9 citations
Article Tier 2

Oxidative Stress in Far Eastern Mussel Mytilus trossulus (Gould, 1850) Exposed to Combined Polystyrene Microspheres (µPSs) and CuO-Nanoparticles (CuO-NPs)

Researchers exposed the marine mussel Mytilus trossulus to polystyrene microspheres and copper oxide nanoparticles alone and in combination for 5 days, finding that both contaminants induced oxidative stress and that combined exposure enhanced lysosomal membrane damage compared to single exposures. The battery of biomarkers including lipid peroxidation, antioxidant activity, and DNA damage provided a sensitive profile of combined toxicity.

2022 Journal of Marine Science and Engineering 15 citations
Article Tier 2

Hypoxia in the Blue Mussel Mytilus chilensis Induces Transcriptome Shift Associated with Endoplasmic Reticulum Stress, Metabolism, and Immune Response.

Scientists used gene expression analysis to study how low-oxygen conditions affect the blue mussel Mytilus chilensis at the molecular level. Researchers found that hypoxia triggered stress responses in the mussels' gills, digestive glands, and muscles, including cellular stress pathways, metabolic shifts, and immune changes. The study highlights how climate-driven oxygen depletion in coastal waters can stress economically important shellfish species.

2024 Preprints.org 5 citations
Article Tier 2

State of the antioxidant defense system in wedge clams from Bulgarian Black Sea as a measure of resistance to environmental impacts

Researchers assessed the antioxidant defense status of wedge clams (Donax trunculus) collected from multiple Bulgarian Black Sea sites in summer and autumn, measuring catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and glutathione. They found that enzyme activity varied seasonally and by site, with elevated GST at tourist-heavy localities in summer suggesting heightened detoxification responses to anthropogenic environmental pressure.

2022 BIORISK – Biodiversity and Ecosystem Risk Assessment 2 citations
Meta Analysis Tier 1

Is microplastic an oxidative stressor? Evidence from a meta-analysis on bivalves

Microplastics induce time-dependent oxidative stress in bivalves, with antioxidant enzymes (GPx, GST, SOD) increasing during short-term exposure but declining after long-term exposure, while glutathione levels and catalase activity remained elevated throughout and may serve as reliable biomarkers of sublethal microplastic effects.

2021 Journal of Hazardous Materials 199 citations
Article Tier 2

H2O2-Induced Oxidative Stress Responses in Eriocheir sinensis: Antioxidant Defense and Immune Gene Expression Dynamics

This study examined how Chinese mitten crabs respond to oxidative stress caused by hydrogen peroxide, finding that their antioxidant defenses and immune gene activity initially ramp up but then collapse under prolonged or high-dose exposure. While not directly about microplastics, the findings are relevant because microplastics are known to trigger similar oxidative stress in aquatic organisms, and this research helps map the biological pathways involved.

2024 Antioxidants 21 citations
Article Tier 2

Metabolic profiles and protein expression responses of Pacific oyster (Crassostrea gigas) to polystyrene microplastic stress

Researchers exposed Pacific oysters to polystyrene microplastics for 21 days and found the particles caused oxidative stress and disrupted the oysters' metabolism, particularly amino acid processing. Different microplastic concentrations triggered different metabolic changes in the oysters. Since oysters are a popular seafood, these findings raise questions about food safety and whether microplastic-stressed shellfish could affect consumer health.

2024 Food Chemistry 15 citations
Article Tier 2

Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism

Comparative genomic and transcriptomic analysis of two closely related oyster species from warm and cold environments found that noncoding sequence divergence and adaptive transcriptional plasticity underpin thermal adaptation, with warm-adapted oysters showing higher plasticity in energy metabolism genes that up-regulate ATP production and lipid catabolism in response to heat.

2021 Molecular Biology and Evolution 68 citations
Article Tier 2

Effects of trace metals and microplastics on the gene expression of antioxidant and detoxification genes in Mytilus galloprovincialis from estuaries

Researchers measured microplastic contamination and trace metal concentrations alongside antioxidant and detoxification gene expression in wild mussels from three estuaries in the Asturias region of Spain. Significant differences in both pollutant levels and gene expression were found between clean and polluted sites, though post-mining estuaries showed signs of recovery.

2025 Chemosphere 2 citations
Article Tier 2

Hemocyte Responses of the Oyster Crassostrea hongkongensis Exposed to Diel-Cycling Hypoxia and Salinity Change

Researchers examined hemocyte immune responses of Hong Kong oysters exposed to diel-cycling hypoxia and salinity fluctuations, conditions that co-occur in estuarine environments and were linked to mass mortality events in the field.

2021 Frontiers in Marine Science 26 citations
Article Tier 2

First Report of OvoA Gene in Marine Arthropods: A New Candidate Stress Biomarker in Copepods

Researchers reported the first identification of the OvoA gene in marine arthropods, specifically in copepods, finding that OvoA expression increases under oxidative stress conditions, establishing it as a candidate stress biomarker for marine pollution monitoring.

2021 Marine Drugs 9 citations
Article Tier 2

Effects of soil trace metals, organic carbon load and physicochemical stressors on active oxygen species metabolism in Scylla serrata sampled along the Bay of Bengal in Odisha state, India

Researchers examined how soil trace metals (calcium and magnesium), organic carbon load, and physicochemical water stressors influence oxidative stress and antioxidant parameters in the edible mud crab Scylla serrata sampled from multiple sites along the Bay of Bengal in Odisha, India. The study found significant spatio-temporal variation in oxidative stress markers across sites with differing environmental conditions, suggesting that combined soil and water quality parameters drive oxidative stress in this ecologically and economically important crab species.

2022 Frontiers in Environmental Science 9 citations
Article Tier 2

Copper-Induced Ionoregulatory Disturbance, Histopathology, and Transcriptome Responses in Freshwater Mussel (Anodonta woodiana) Gills

Researchers investigated copper toxicity in the freshwater mussel Anodonta woodiana, finding that sublethal exposure caused ionoregulatory disturbance, gill histopathology, and significant transcriptomic changes related to stress response and immune function.

2023 Fishes 10 citations
Article Tier 2

Effects of Microplastics Associated with Triclosan on the Oyster Crassostrea brasiliana: An Integrated Biomarker Approach

Brazilian oysters (Crassostrea brasiliana) were exposed to microplastics alone and in combination with the antibacterial chemical triclosan, with combined exposure causing greater oxidative stress, immune disruption, and genotoxicity than either stressor alone.

2020 Archives of Environmental Contamination and Toxicology 63 citations
Article Tier 2

Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent

Researchers exposed freshwater mussels to industrial wastewater effluent containing elevated levels of copper, nickel, and zinc, then measured a panel of molecular stress markers in gill and digestive tissue. While most markers showed little change, increased nerve enzyme activity and heat shock protein expression were detected, suggesting mussels can serve as sensitive pollution bioindicators but require more research to standardize responses.

2021 Environmental Science and Pollution Research 36 citations
Article Tier 2

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Triangle sail mussels exposed to sub-lethal ammonia concentrations showed antioxidant enzyme activation followed by inhibition, with the highest stress responses in gills and hepatopancreas and histopathological damage suggesting oxidative stress as a key mechanism of ammonia toxicity.

2021 Water 35 citations
Article Tier 2

A Survey on the Distribution of Ovothiol and ovoA Gene Expression in Different Tissues and Cells: A Comparative Analysis in Sea Urchins and Mussels

Researchers compared ovothiol biosynthesis in sea urchins (Paracentrotus lividus) and mussels (Mytilus galloprovincialis) by measuring ovothiol content across tissues and immune cells and analyzing ovoA gene expression from publicly available transcriptomes. They identified tissue-specific and species-specific patterns of ovothiol production, providing a foundation for biotechnological investigation of these potent natural antioxidants sourced from marine invertebrates.

2022 Marine Drugs 11 citations
Article Tier 2

Oxidative and metabolic responses in Crassostrea gasar under combined stressors of elevated temperature and microplastic exposure

Researchers exposed oysters (Crassostrea gasar) to polystyrene microplastics at different temperatures to assess their combined effects on oxidative stress and energy metabolism. The study found that both gills and digestive glands accumulated microplastics regardless of temperature, and that the combination of thermal stress and microplastic exposure produced distinct patterns of oxidative stress and metabolic disruption compared to either stressor alone.

2025 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 1 citations
Article Tier 2

Physiological and transcriptomic analyses reveal critical immune responses to hypoxia and sulfide in the haemolymph of clam Tegillarca granosa

This paper is not relevant to microplastics research — it examines how hypoxia and sulfide exposure affect immune responses in blood clams (Tegillarca granosa) at a physiological and transcriptomic level.

2023 Frontiers in Marine Science 10 citations