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20 resultsShowing papers similar to Lutein Can Alleviate Oxidative Stress, Inflammation, and Apoptosis Induced by Excessive Alcohol to Ameliorate Reproductive Damage in Male Rats
ClearThe Possible Protective Effect of Luteolin in a Thioacetamide Rat Model of Testicular Toxicity
This animal study tested whether luteolin, a natural plant compound with antioxidant properties, could protect against testicular toxicity caused by thioacetamide. The study establishes an animal model for studying reproductive toxicity and evaluates whether natural antioxidants can mitigate oxidative damage to sperm-producing tissues.
Toxic effect of polyethylene microplastic on testicles and ameliorative effect of luteolin in adult rats: Environmental challenge
Researchers found that polyethylene microplastics caused significant testicular toxicity in adult rats including reduced sperm quality and testosterone levels, while luteolin treatment ameliorated these effects through its antioxidant and anti-inflammatory properties.
The effect of luteolin on spermatological parameters, apoptosis, oxidative stress rate in freezing rabbit semen
Researchers examined the effect of the flavonoid luteolin at four concentrations (25, 50, 100, and 200 µM) on semen quality, oxidative stress, apoptosis, acrosomal integrity, mitochondrial membrane potential, and dead sperm ratio in frozen-thawed New Zealand rabbit semen. Results showed no statistically significant differences between any luteolin dose and the control group across the assessed spermatological parameters.
Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albino rats
Researchers studied whether the plant compound rhamnetin could protect against testicular damage caused by polystyrene microplastics in rats. Microplastic exposure caused significant harm to sperm quality, hormone levels, and testicular tissue through oxidative stress and inflammation. Co-treatment with rhamnetin restored many of these markers, suggesting it may help counteract some of the reproductive harm associated with microplastic exposure.
New Insight on the In Vitro Effects of Melatonin in Preserving Human Sperm Quality
Researchers found that melatonin protects human sperm quality against cadmium-induced oxidative stress in vitro, preserving motility, viability, DNA integrity, and mitochondrial function while reducing lipid peroxidation over 24 hours of exposure.
Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics–instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment
In a rat study, polystyrene microplastics caused significant damage to the testes, including reduced sperm quality, oxidative stress, and tissue inflammation, but the natural plant compound ginkgetin was able to partially reverse this damage. Ginkgetin worked by boosting antioxidant defenses and reducing the inflammatory response triggered by the microplastics. This suggests that natural antioxidant compounds might help protect male reproductive health from the harmful effects of microplastic exposure.
Lycopene supplement mitigates polystyrene microplastics (PS-MPs)-induced reproductive alteration in rats via modulation of steroidogenic enzymes, inhibition of apoptosis and oxido-inflammatory reaction
Researchers found that lycopene, a natural antioxidant found in tomatoes, helped protect male rats from reproductive damage caused by polystyrene microplastic exposure. The microplastics disrupted hormone levels and sperm quality, but lycopene supplementation reduced oxidative stress and inflammation in reproductive tissues. The study suggests that dietary antioxidants may help counteract some of the harmful reproductive effects associated with microplastic exposure.
Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A
Researchers investigated whether melatonin could alleviate oxidative stress damage caused by bisphenol A (BPA) exposure in mouse testicular tissue. The study found that melatonin treatment reduced BPA-induced oxidative damage and improved sperm quality indicators, suggesting a potential protective role against the reproductive effects of this common plastic-associated chemical.
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Researchers investigated whether the plant compound chrysoeriol could protect against testicular damage caused by polyethylene microplastics in a rat model. The study found that microplastic exposure reduced antioxidant enzyme activity and increased inflammation markers, while co-administration of chrysoeriol showed a protective effect by mitigating oxidative stress and preserving sperm quality.
Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice
Researchers tested extracts from the plant Allium ochotense for their ability to protect against alcohol-induced liver damage in mice. The study found that the extracts improved lipid metabolism, reduced liver inflammation, and boosted antioxidant defenses, suggesting potential as a natural approach to supporting liver health in the context of chronic alcohol consumption.
Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats
Researchers showed that arsenic — a heavy metal contaminant found alongside plastic pollution in many environments — severely damages sperm quality and hormone levels in male rats, and that the plant compound fisetin significantly reversed this damage. The results suggest fisetin may help protect male reproductive health from toxic environmental exposures.
Attenuative effect of astilbin on polystyrene microplastics induced testicular damage: Biochemical, spermatological and histopathological-based evidences
Researchers found that astilbin, a natural plant compound, significantly reduced testicular damage caused by polystyrene microplastic exposure in rats. The microplastics disrupted hormone levels, sperm quality, and testicular tissue structure, but astilbin treatment counteracted these effects by boosting antioxidant defenses and reducing inflammation. The study suggests that natural antioxidant compounds may offer protective benefits against the reproductive harm associated with microplastic exposure.
Metabolic–endocrine remodelling of the testis under polystyrene nanoplastic exposure: Intervention by organ-specific phytocomplexes of Nelumbo nucifera
Researchers found that polystyrene nanoplastics impair testosterone production and sperm quality in male rats by inducing testicular oxidative stress and disrupting cholesterol and energy metabolism, and showed that extracts from lotus plant organs — especially the rhizome — significantly protected testicular function through antioxidant and anti-inflammatory mechanisms.
Apigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study
Researchers tested whether the flavonoid apigetrin could protect rat testicular tissue from damage caused by the chemotherapy drug doxorubicin. They found that doxorubicin caused significant oxidative stress, inflammation, hormone imbalance, and tissue damage in the testes, but co-administration of apigetrin substantially reduced these harmful effects. The study suggests that natural plant compounds may help protect reproductive health during cancer treatment.
Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats
Researchers tested whether fucoidan, a compound extracted from brown seaweed, could protect against reproductive damage caused by polystyrene microplastic exposure in male rats. They found that fucoidan treatment enhanced antioxidant enzyme activity, reduced inflammation markers, and preserved testicular tissue structure and testosterone levels. The study suggests that fucoidan may help counteract microplastic-induced oxidative stress in reproductive tissues.
Oxidative Stress and Male Fertility: Promising Role of Nutraceuticals
This paper is not about microplastics; it reviews the role of oxidative stress in male infertility and the potential of nutraceuticals (antioxidant-rich dietary supplements) to improve sperm quality and hormonal profiles, with no connection to microplastic research.
Epigallocatechin-gallate ameliorates polystyrene microplastics-induced oxido-inflammation and mitochondria-mediated apoptosis in testicular cells via modulation of Nrf2/HO-1, /mTOR/Atg-7, and Cx-43/NOX-1 levels
Researchers found that polystyrene microplastics caused oxidative stress, inflammation, and reduced sperm quality in rats, but that treatment with EGCG — a compound found in green tea — reversed most of these harmful effects by restoring antioxidant defenses and reducing cell death pathways in testicular tissue.
Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility
This review examines how oxidative stress affects male livestock reproductive function by disrupting autophagy processes in the testes. The study suggests that oxidative stress-induced autophagy dysfunction can impair spermatogenesis, reduce sperm quality, compromise testosterone synthesis, and damage the blood-testis barrier, with implications for improving livestock breeding outcomes.
Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats
Researchers found that Moringa oleifera leaf extract protected rats from testicular damage caused by uranyl acetate, a toxic uranium compound, by boosting antioxidant defenses and reducing oxidative stress. While focused on uranium toxicity, the protective mechanisms studied are relevant to microplastics research because microplastics also cause testicular damage through oxidative stress in animal studies. Natural antioxidants like those in Moringa may help protect reproductive health from environmental pollutants.
Rutin Protects Liver and Kidneys against the Toxicity of Plastic Compounds in Rats
Rats exposed to bisphenol A and dibutyl phthalate — two chemicals commonly leached from plastics — showed elevated liver and kidney damage markers, oxidative stress, and adverse changes in cholesterol profiles. Treatment with rutin, a natural flavonoid supplement, significantly reversed these effects, suggesting it may help counteract the organ toxicity associated with chronic low-level plastic chemical exposure.