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Lycopene supplement mitigates polystyrene microplastics (PS-MPs)-induced reproductive alteration in rats via modulation of steroidogenic enzymes, inhibition of apoptosis and oxido-inflammatory reaction
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Researchers found that lycopene, a natural antioxidant found in tomatoes, helped protect male rats from reproductive damage caused by polystyrene microplastic exposure. The microplastics disrupted hormone levels and sperm quality, but lycopene supplementation reduced oxidative stress and inflammation in reproductive tissues. The study suggests that dietary antioxidants may help counteract some of the harmful reproductive effects associated with microplastic exposure.
Increasing levels of polystyrene microplastics (PS-MPs) in the environment poses huge global health threat. Prolonged exposure to PS-MPs results in both male and female infertility, with a deleterious effect on reproductive health. In rats, the disruptive effects of chemotoxicants have been countered by lycopene (LYC). This study examined the protective benefits of lycopene (LYC) against spermatological damage and hormonal alterations brought on by polystyrene microplastics (PS-MPs) in male rats. Twenty Wistar rats were split into four groups of five rats, each consisting of: the control group, the PSMPs treatment group, the PS-MPs + LYC co-treatment group, and the LYC supplementation group. Severe testicular histological damage was seen to have resulted from exposure to PS-MPs. The PS-MPs treatment dramatically reduced the antioxidant enzyme activities while raising the levels of ROS and MDA, thus reducing sperm progressive motility. Also, spermatological damage and hormonal alterations brought on by polystyrene microplastics (PS-MPs) were also prevented by the effects of lycopene (LYC). In conclusion, LYC supplementation has the ability to reduce the harmful effects of PS-MPs on the male reproductive system. Accordingly, LYC prevented PS-MPs-induced spermatological damage and reproductive hormonal changes in rats via its anti-oxidant, androgenic, anti-apoptotic, anti-inflammatory properties.
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Lycopene againsts the polystyrene microplastics-induced neurotoxicity via modulation of mTOR/Beclin-1 activities in adult male Wistar rats
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Twenty Wistar rats were given polystyrene microplastics, lycopene, both or neither by mouth for 56 days. Microplastics raised markers of oxidative stress in the brain and disturbed neurotransmitter balance. Rats that also received lycopene, a compound found in tomatoes, showed smaller changes.
Attenuative effect of astilbin on polystyrene microplastics induced testicular damage: Biochemical, spermatological and histopathological-based evidences
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Researchers found that astilbin, a natural plant compound, significantly reduced testicular damage caused by polystyrene microplastic exposure in rats. The microplastics disrupted hormone levels, sperm quality, and testicular tissue structure, but astilbin treatment counteracted these effects by boosting antioxidant defenses and reducing inflammation. The study suggests that natural antioxidant compounds may offer protective benefits against the reproductive harm associated with microplastic exposure.
Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albino rats
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Researchers studied whether the plant compound rhamnetin could protect against testicular damage caused by polystyrene microplastics in rats. Microplastic exposure caused significant harm to sperm quality, hormone levels, and testicular tissue through oxidative stress and inflammation. Co-treatment with rhamnetin restored many of these markers, suggesting it may help counteract some of the reproductive harm associated with microplastic exposure.
Natural Antioxidants can Improve Microplastics-Induced Male Reproductive Impairment in the African Catfish (Clarias Gariepinus)
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Researchers found that natural antioxidants including lycopene, citric acid, and Chlorella can protect against microplastic-induced reproductive damage in male African catfish, offering potential dietary strategies to mitigate microplastic toxicity in aquaculture.
Impact of polystyrene microplastic exposure at low doses on male fertility: an experimental study in rats
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Researchers exposed adult male rats to varying doses of polystyrene microplastics and found dose-dependent declines in semen quality along with disrupted reproductive hormone levels. Higher doses caused increased oxidative stress, mitochondrial damage, and inflammatory responses in testicular tissue. The study suggests that even relatively low doses of microplastic exposure may have adverse effects on male reproductive health in animal models.
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