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Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility
Summary
This review examines how oxidative stress affects male livestock reproductive function by disrupting autophagy processes in the testes. The study suggests that oxidative stress-induced autophagy dysfunction can impair spermatogenesis, reduce sperm quality, compromise testosterone synthesis, and damage the blood-testis barrier, with implications for improving livestock breeding outcomes.
This review systematically examines the influence of oxidative stress on the reproductive function of male livestock, with a particular focus on the modulation of autophagy. Spermatogenesis, a highly precise biological process, is vulnerable to a range of internal and external factors, among which oxidative stress notably disrupts autophagic processes within the testes. This disruption results in diminished sperm quality, impaired testosterone synthesis, and compromised integrity of the blood-testis barrier. Furthermore, this review elucidates the molecular mechanisms by which oxidative stress-induced autophagy dysfunction impairs spermatogenesis and mitochondrial function, consequently reducing sperm motility. These findings aim to provide a theoretical foundation and serve as a reference for improving reproductive performance and sperm quality in livestock.
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