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61,005 resultsShowing papers similar to Effectiveness of N-Acetylcysteine on Zinc oxide Nanoparticles-Induced Cardiotoxicity in Adult Albino Rats
ClearProtective effects of Vitamin E against Zinc Oxide nanoparticles-induced histotoxicity of liver and testicular tissue, genotoxicity and biomarker stress in male albino rats
This rat study examined whether vitamin E could protect against liver and testicular damage caused by zinc oxide nanoparticles at doses of 50 and 200 mg/kg. Vitamin E at 100 mg/kg provided significant protection against ZnO nanoparticle-induced tissue damage, genotoxicity, and oxidative stress markers.
Protective Effects of Theaflavins and Epigallocatechin Gallate against ZnO-NP-Induced Cell Apoptosis In Vitro
Researchers evaluated whether theaflavins (TFs) and epigallocatechin gallate (EGCG) could protect rat tracheal epithelial cells against zinc oxide nanoparticle (ZnO-NP)-induced cytotoxicity, exposing cells to 100 micrograms per liter ZnO-NPs followed by varying concentrations of the tea polyphenols and measuring oxidative stress, inflammation, and apoptosis markers. Both compounds showed protective effects against ZnO-NP-induced cell damage in a dose-dependent manner.
Investigation of pulmonary toxicity evaluation on mice exposed to polystyrene nanoplastics: The potential protective role of the antioxidant N-acetylcysteine
Researchers investigated lung damage in mice exposed to inhaled polystyrene nanoplastics and tested whether the antioxidant N-acetylcysteine could offer protection. They found that nanoplastics caused significant lung inflammation, tissue damage, and oxidative stress, but N-acetylcysteine treatment helped reduce these harmful effects. The study suggests that oxidative stress is a key mechanism behind nanoplastic-induced lung injury and points to potential protective strategies.
N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl2 in primary spleen lymphocytes
Researchers found that N-acetyl-L-cysteine (NAC) alleviated oxidative stress-induced inflammation and cell death caused by microplastic exposure, suggesting NAC may protect against microplastic toxicity. The findings point to antioxidant supplementation as a potential mitigation strategy for microplastic-related cellular damage.
Determination of Oxidative Stress Responses Caused by Zinc Oxide Nanoparticle on Gammarus Pulex
Gammarus pulex, a freshwater invertebrate indicator species, was exposed to zinc oxide nanoparticles at 0, 10, 20, and 40 ppm for 24 and 96 hours to assess oxidative stress responses. The study measured antioxidant enzyme activities and related biomarkers, finding concentration- and time-dependent oxidative stress effects.
Combined cerium and zinc oxide nanoparticles induced hepato-renal damage in rats through oxidative stress mediated inflammation
Researchers found that combined cerium and zinc oxide nanoparticles induced liver and kidney damage in rats through oxidative stress-mediated inflammation, demonstrating that co-exposure to multiple nanoparticles can produce synergistic toxic effects.
Use of DNA adduct and histopathological defects as indications for bio-persistence potency of zinc oxide nanoparticles in gastropod, Monacha cartusiana (Mǜller) after short-term exposure
Researchers assessed the bio-persistence and adverse effects of zinc oxide nanoparticles in the gastropod Monacha cartusiana after short-term exposure, using DNA adduct formation and histopathological defects as biomarkers to characterize cytotoxic and genomic damage from metallic nanoparticle exposure.
Combined cerium and zinc oxide nanoparticles induced hepato-renal damage in rats through oxidative stress mediated inflammation
Researchers found that exposing rats to cerium oxide and zinc oxide nanoparticles — alone or in combination — caused liver and kidney damage by triggering oxidative stress and inflammatory signaling, with the combined treatment producing distinct toxicity patterns compared to either nanoparticle alone.
Evaluating the Effectiveness of Vitamins E and C in Mitigating the Toxic Effects of Zinc Oxide Bulk and Nanoparticles on Fish: A Review
This paper is not relevant to microplastics — it is a review of how vitamins E and C can reduce the toxic effects of zinc oxide nanoparticles on fish in aquatic environments.
Clinicopathological Studies on the Impact of Grape Seed Extract and L-Carnitine as Cardioprotective Agents Against Doxorubicin-Induced Toxicity in Rats
Researchers investigated whether grape seed extract and L-Carnitine could protect rat hearts from the toxic side effects of the cancer drug doxorubicin. Both supplements significantly reduced heart damage markers, lipid oxidation, and inflammation while improving antioxidant enzyme levels. The study suggests these natural compounds may offer protective benefits against drug-induced cardiac injury through their antioxidant and anti-inflammatory properties.
Assessment of the protective and ameliorative impact of quercetin nanoparticles against neuronal damage induced in the hippocampus by acrolein
Researchers found that quercetin nanoparticles — tiny particles of a natural antioxidant found in plants — protected brain cells in the hippocampus from damage caused by acrolein, a toxic compound linked to Alzheimer's disease, suggesting nanoparticle delivery of quercetin as a potential therapeutic strategy.
Effects of polystyrene microplastics on mice cardiac tissue structure: Protective role of resveratrol
Researchers exposed mice to polystyrene microplastics for 90 days and found that the particles caused significant oxidative stress and structural damage to heart tissue. However, when mice also received resveratrol, a natural antioxidant compound found in grapes and berries, much of the cardiac damage was prevented. The study suggests that antioxidant compounds may offer some protective benefit against microplastic-induced heart tissue damage.
Modulation efficiency of clove oil nano-emulsion against genotoxic, oxidative stress, and histological injuries induced via titanium dioxide nanoparticles in mice
Researchers found that titanium dioxide nanoparticles (used widely in sunscreens and food products) caused DNA damage, oxidative stress, and organ tissue injury in mice, but that a clove oil nanoemulsion significantly reversed these harmful effects — suggesting a natural antioxidant treatment may protect against nanoparticle toxicity.
Protection of Exogenous Antioxidant of Cinnamomum burmanii as a Hepatoprotective on the Toxicological Responses of Nanoplastics in Rats (Rattus norvegicus L.)
Researchers tested whether Cinnamomum burmanni leaf extract (CLE) protects rat liver function from polystyrene nanoplastic toxicity, administering NPs orally for 14 days with or without 100–400 mg/kg CLE for 28 days. NPs caused oxidative stress and liver damage, while CLE at 200–400 mg/kg significantly reduced hepatotoxicity markers and restored antioxidant enzyme activity, suggesting hepatoprotective potential against nanoplastic-induced toxicity.
Protective role of poncirin against polyethylene microplastics instigatedcardiac toxicity via regulating Nrf2/keap1 pathway
Researchers found that exposing rats to polyethylene microplastics caused significant heart damage — including oxidative stress, inflammation, and cell death — by disrupting the Nrf2 antioxidant defense pathway. Supplementing with poncirin, a natural plant flavonoid, substantially protected cardiac tissue by restoring antioxidant activity, suggesting a potential protective role against microplastic-induced heart toxicity.
N-acetylcysteine suppresses proteasome pathway activation and muscular damage induced by microplastics and chromium nanoparticles
Researchers found chromium nanoparticles and microplastics co-accumulating in human peri-implant muscle tissue from orthopedic patients, and showed in vitro that their combined exposure elevated reactive oxygen species and pro-inflammatory markers, while the antioxidant N-acetylcysteine suppressed the proteasome pathway activation and muscle damage.
Natural Bioactive Phytocompounds to Reduce Toxicity in Common Carp Cyprinus carpio: A Challenge to Environmental Risk Assessment of Nanomaterials
Researchers investigated the toxic effects of copper oxide nanoparticles on common carp and found that Myristica fragrans seed extract provided protective benefits by reducing oxidative stress and mitigating nanoparticle-induced damage.
Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats
Researchers orally exposed Wistar rats to polystyrene nanoplastics at multiple doses for five weeks and observed dose-dependent increases in oxidative stress. The study found significant alterations in liver and kidney function markers, disrupted energy metabolism, and changes in antioxidant enzyme activity, suggesting that nanoplastic exposure may affect multiple organ systems in mammals.
Fe2+ Alleviated the Toxicity of ZnO Nanoparticles to Pseudomonas tolaasii Y-11 by Changing Nanoparticles Behavior in Solution
Researchers found that Fe2+ ions alleviated the toxicity of ZnO nanoparticles to Pseudomonas tolaasii Y-11 by altering nanoparticle behavior in solution, thereby protecting the bacterium's ability to remove nitrate.
Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure
This study tested whether the antioxidant flavonoid quercetin could protect rats from oxidative damage caused by xenobiotic (foreign chemical) exposure, finding that quercetin administration reduced biomarkers of oxidative stress and liver damage. The results suggest that natural antioxidants may help counteract some biochemical effects of environmental chemical exposures.
Histological, Haematological, and thyroid hormones toxicity of oral exposure to CuO/ZnO core/shell nanoparticles in female rats
Researchers assessed the in vivo toxicity of CuO/ZnO core/shell nanoparticles (30 nm) in female albino rats via 30-day oral administration at doses from 5 to 40 mg/L, finding significant alterations in white blood cells, red blood cells, hemoglobin, hematocrit, and thyroid hormone levels, indicating systemic toxicity at low doses.
Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos
Researchers investigated the toxicity of zinc oxide nanoparticles on human brain glial cells and zebrafish embryos, finding that both were harmed at relatively low concentrations. The nanoparticles reduced cell viability in the glial cells and caused developmental abnormalities in the zebrafish embryos. The study suggests that the dissolved zinc ions released from these widely used nanoparticles play a significant role in their toxic effects on the nervous system.
Silica Nanoparticle Acute Toxicity on Male Rattus norvegicus Domestica: Ethological Behavior, Hematological Disorders, Biochemical Analyses, Hepato-Renal Function, and Antioxidant-Immune Response
Researchers assessed the acute toxicity of silica nanoparticles in male rats, finding significant hematological disorders, liver and kidney damage, oxidative stress, and immune system disruption at higher doses after 24 and 96 hours of exposure.
Toxicity of polystyrene nanoplastics and zinc oxide to mice
Mice injected intraperitoneally with environmentally relevant doses of ZnO nanoparticles or polystyrene nanoplastics showed cognitive impairment in recognition tests, while combined exposure produced genotoxic effects and biochemical stress markers, indicating neurotoxic and genotoxic potential.