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61,005 resultsShowing papers similar to Polystyrene microplastics inhibit the neurodevelopmental toxicity of mercury in zebrafish (Danio rerio) larvae with size-dependent effects
ClearPolystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption
Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.
Polystyrene Nanoplastic Exposure Adversely Affects Survivability of Zebrafish Larvae
Researchers found that polystyrene nanoplastic exposure significantly reduces survival rates of zebrafish larvae in a dose-dependent manner, documenting behavioral abnormalities and developmental defects that highlight the toxicity of nanoscale plastic particles to early vertebrate life.
Evaluation of phenotypic and behavioral toxicity of micro- and nano-plastic polystyrene particles in larval zebrafish ( Danio rerio )
Researchers exposed larval zebrafish (Danio rerio) to six sizes (0.05–10.2 µm) and multiple concentrations of polystyrene micro/nanoplastics and assessed toxicity using embryo and behavioral assays. Smaller particles and higher concentrations caused greater phenotypic and behavioral toxicity, with particle uptake and organ distribution confirmed, establishing size as a key determinant of polystyrene MP toxicity in a vertebrate developmental model.
Effects of microplastics on the accumulation and neurotoxicity of methylmercury in zebrafish larvae
Researchers found that microplastics can adsorb methylmercury and act as carriers, increasing its accumulation in zebrafish larvae and worsening neurotoxicity by disrupting locomotor activity and triggering oxidative stress.
Polystyrene microplastics mitigate lead-induced neurotoxicity by reducing heavy metal uptake in zebrafish larvae
In a surprising finding, this zebrafish study showed that polystyrene microplastics actually reduced the neurotoxic effects of lead by absorbing the heavy metal and lowering how much the fish took in. The microplastics essentially acted as a sponge for lead in the water, decreasing the amount available to harm developing fish brains. However, this does not mean microplastics are beneficial, as the particles may transport absorbed heavy metals to other parts of the environment or release them under different conditions.
Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.
Mechanisms Underlying the Size-Dependent Neurotoxicity of Polystyrene Nanoplastics in Zebrafish
Scientists discovered that smaller nanoplastics cause more severe brain and nerve damage in zebrafish than larger ones, and identified the molecular pathways behind this size-dependent toxicity. The smaller particles more easily crossed biological barriers and triggered greater oxidative stress and inflammation in the nervous system, which is important for understanding potential neurological risks of nanoplastic exposure.
Polystyrene nanoplastics enhance the toxicological effects of DDE in zebrafish (Danio rerio) larvae
Researchers found that polystyrene nanoplastics enhanced the toxicity of the pesticide metabolite DDE in zebrafish larvae, with co-exposure causing greater developmental abnormalities and oxidative stress than either pollutant alone.
Effects of nanoplastics on zebrafish embryo-larval stages: A case study with polystyrene (PS) and polymethylmethacrylate (PMMA) particles
Researchers assessed the effects of polystyrene and polymethylmethacrylate nanoparticles on zebrafish embryos and larvae over 96 hours. The study found that these nanoplastics affected biochemical endpoints related to neurotransmission, antioxidant status, oxidative damage, and energy metabolism, with effects varying by plastic type. Evidence suggests that smaller plastic particles may have increased bioavailability and reactivity compared to larger fragments.
The Trojan horse effect of nanoplastics exacerbates methylmercury-induced neurotoxicity during zebrafish development
This zebrafish study showed that 250 nm polystyrene nanoplastics can act as a Trojan horse by enhancing methylmercury accumulation and directing it toward the head and eyes of larvae over 30 days. Combined exposure worsened behavioral impairment and developmental defects beyond what either contaminant caused alone.
Size-dependent impact of polystyrene microplastics on the toxicity of cadmium through altering neutrophil expression and metabolic regulation in zebrafish larvae
Researchers used transgenic zebrafish larvae to study how different sizes of polystyrene particles affect cadmium toxicity through changes in immune cell (neutrophil) expression. They found that micro-sized particles reduced cadmium toxicity by lowering cadmium uptake, while nano-sized particles maintained high immune responses due to increased oxidative stress, demonstrating that particle size plays a critical role in combined pollutant effects.
Bioaccumulation of various nanoplastic particles in larval zebrafish (Danio rerio)
Researchers exposed larval zebrafish (Danio rerio) to 40-60 nm and 100 nm polystyrene nanoplastic particles using standard fish embryo toxicity and general behavioral toxicity assays from 6-120 hours post-fertilization, combining toxicity endpoints with fluorescence microscopy to confirm particle uptake and excretion. The study demonstrated nanoplastic accumulation within zebrafish larvae at tested concentrations, providing mechanistic insights into aquatic organism exposure dynamics for nanoplastics.
Evaluation of phenotypic and behavioral toxicity of micro- and nano-plastic polystyrene particles in larval zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene particles ranging from 50 nanometers to 10 micrometers and found that nearly all sizes caused physical abnormalities and changes in swimming behavior. Smaller particles were taken up more readily and distributed to organs including the brain and gut. These findings are relevant to human health because zebrafish share many biological pathways with humans, and the results suggest that both micro- and nano-sized plastics can cause developmental harm.
Immunotoxicity responses to polystyrene nanoplastics and their related mechanisms in the liver of zebrafish (Danio rerio) larvae
Researchers studied how polystyrene nanoplastics affect the immune system of zebrafish larvae by examining inflammatory responses in the liver. They found that smaller nanoparticles caused more severe immune reactions, including increased neutrophil and macrophage activity and activation of inflammatory signaling pathways. The study provides evidence that nanoplastics can trigger significant immune system disruption in fish even at early life stages.
From particle size to brain function: a zebrafish-based review of micro/nanoplastic-induced neurobehavioral toxicity and mechanistic pathways
This review uses zebrafish as a model to examine how micro- and nanoplastics cause neurobehavioral toxicity, linking particle size to brain function disruption. Researchers summarize evidence that these plastic particles impair fish behavior and cause molecular-level damage in the nervous system. The findings highlight the growing concern that micro- and nanoplastics are emerging neurotoxicants in aquatic environments.
Polystyrene nanoplastics induced size-dependent developmental and neurobehavioral toxicities in embryonic and juvenile zebrafish
Researchers exposed zebrafish embryos and juveniles to polystyrene nanoplastics of three different sizes and found that all sizes crossed into the brain, eyes, and other organs. Smaller particles tended to cause different types of damage than larger ones, including changes in brain development and behavior. This size-dependent toxicity is relevant to human health because we are exposed to a wide range of nanoplastic sizes through food and water.
Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism
Researchers used zebrafish as a model organism to study the toxic effects of polystyrene nanoplastics at both cellular and whole-organism levels. They found that smaller nanoplastic particles were taken up more readily by cells and caused greater oxidative stress and developmental abnormalities than larger particles. The study confirms that particle size is a critical determinant of nanoplastic toxicity, with the smallest particles posing the greatest biological risks.
Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure
Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.
The mechanism of polystyrene nanoplastics hepatotoxicity in zebrafish (Danio rerio)
This study investigated the hepatotoxic mechanisms of polystyrene nanoplastics in zebrafish (Danio rerio), finding that nanoplastics accumulating in the liver triggered oxidative stress and cellular injury pathways. The results highlight nanoplastics as a significant liver toxicant in aquatic vertebrates.
Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development
Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.
Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
Microplastics induced developmental toxicity with microcirculation dysfunction in zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene microplastics (1 micrometer) and nanoplastics (0.4 micrometer) to assess developmental toxicity. They found that nanoplastics caused significantly higher mortality and more severe microcirculation dysfunction than microplastics, despite being less visible in solution. The study indicates that smaller plastic particles may pose greater developmental risks to aquatic organisms during early life stages.
Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: Are larger plastic particles more harmless?
Researchers exposed red tilapia to three sizes of polystyrene particles (0.3, 5, and 70-90 micrometers) to compare their toxic effects. The study found that the largest particles showed the highest accumulation in tissues, but all sizes induced oxidative stress, disrupted cytochrome P450 enzymes, caused neurotoxicity, and altered metabolic profiles, indicating that even smaller nanoplastics can cause significant harm to fish.
Polystyrene microplastics alleviate the developmental toxicity of silver nanoparticles in embryo-larval zebrafish (Danio rerio) at the transcriptomic level
In a surprising finding, researchers discovered that when zebrafish embryos were exposed to both silver nanoparticles and polystyrene microplastics together, the microplastics actually reduced the toxic effects of the silver nanoparticles. The study suggests that microplastics may interact with other pollutants in complex ways, sometimes lessening rather than amplifying their harmful impacts on developing organisms.