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Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: Are larger plastic particles more harmless?

Journal of Hazardous Materials 2020 253 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Wenbin Zhu, Jiannan Ding, Yejing Huang, Wenbin Zhu, Yejing Huang, Jiannan Ding, Shanshan Zhang, Wenbin Zhu, Wenbin Zhu, Zhenyu Wang Jiannan Ding, Jiannan Ding, Jiannan Ding, Jiannan Ding, Shanshan Zhang, Shanshan Zhang, Shanshan Zhang, Jiannan Ding, Yejing Huang, Yejing Huang, Jiannan Ding, Jiannan Ding, Hua Zou, Zhenyu Wang Shanshan Zhang, Shujiao Liu, Jiannan Ding, Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Hua Zou, Zhenyu Wang Zhenyu Wang Zhenyu Wang Hua Zou, Jiannan Ding, Shanshan Zhang, Shujiao Liu, Wenbin Zhu, Zhenyu Wang Hua Zou, Hua Zou, Hua Zou, Zhenyu Wang Zhenyu Wang Hua Zou, Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Wenbin Zhu, Jiannan Ding, Jinju Geng, Jiannan Ding, Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Hua Zou, Hua Zou, Hua Zou, Zhenyu Wang Zhenyu Wang Wenbin Zhu, Jinju Geng, Wenbin Zhu, Wenbin Zhu, Wenbin Zhu, Hua Zou, Zhenyu Wang Zhenyu Wang Wenbin Zhu, Wenbin Zhu, Zhenyu Wang Zhenyu Wang Wenbin Zhu, Jiannan Ding, Wenbin Zhu, Zhenyu Wang Jinju Geng, Jinju Geng, Zhenyu Wang Jiannan Ding, Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang Zhenyu Wang

Summary

Researchers exposed red tilapia to three sizes of polystyrene particles (0.3, 5, and 70-90 micrometers) to compare their toxic effects. The study found that the largest particles showed the highest accumulation in tissues, but all sizes induced oxidative stress, disrupted cytochrome P450 enzymes, caused neurotoxicity, and altered metabolic profiles, indicating that even smaller nanoplastics can cause significant harm to fish.

Polymers

Body Systems

Hepatic Nervous

Models

Fish other

Nanoplastics (NPs) and microplastics (MPs) are a heterogeneous class of pollutants with diverse sizes in aquatic environments. To evaluate the hazardous effects of N/MPs with different sizes, the accumulation, oxidative stress, cytochrome P450 (CYP) enzymes, neurotoxicity, and metabolomics changes were investigated in the red tilapia exposed to three sizes of polystyrene (PS) N/MPs (0.3, 5, and 70 - 90 μm). After 14-d exposures, the largest particles (70 - 90 μm) showed the highest accumulation levels in most cases. Exposures to PS-MPs (5 and 70 - 90 μm) caused a more severe oxidative stress in red tilapia than PS-NPs. The activity of CYP3A-related enzyme was obviously inhibited by PS-NPs, whereas the CYP enzymes in the liver may not be sensitive to MP exposures. In the brain, only 5 μm PS-MPs significantly inhibited the acetylcholinesterase activity. After exposures, the treatments with 0.3, 5, and 70 - 90 μm N/MPs resulted in 31, 40, and 23 significantly differentially expressed metabolites, respectively, in which the pathway of tyrosine metabolism was significantly affected by all the three PS-N/MP exposures. Overall, the PS particles within the μm size posed more severe stress to red tilapia. Our results suggest that the toxicity of N/MPs may not show a simply monotonic negative correlation with their sizes.

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