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61,005 resultsShowing papers similar to Combined transcriptome and metabolite profiling analyses provide insights into the chronic toxicity of carbaryl and acetamiprid to Apis mellifera larvae
ClearCombined transcriptome and metabolite profiling analyses provide insights into the chronic toxicity of carbaryl and acetamiprid to Apis mellifera larvae
Researchers exposed honeybee larvae in vitro to no-observed-adverse-effect concentrations of the insecticides carbaryl and acetamiprid and used combined transcriptome and metabolite profiling to reveal that carbaryl disrupted oxidative stress responses and amino acid metabolism, while acetamiprid altered different metabolic pathways.
How Environmental and Ecological Stressors Reprogram Honey Bee Chemistry Through the Microbiome–Metabolome Axis
Researchers reviewed how major environmental stressors — including pesticides, pathogens, nutritional imbalance, and contaminants — disrupt the honey bee gut microbiome-metabolome axis, finding recurring patterns of functional dysbiosis such as impaired energy metabolism and weakened immune regulation that can scale up to threaten colony resilience.
Assessing the effects of a commercial fungicide and an herbicide, alone and in combination, on Apis mellifera: Insights from biomarkers and cognitive analysis
Researchers tested the combined effects of a commercial fungicide and herbicide on honey bees and found that the mixture was more harmful than either chemical alone. The pesticide combination impaired the bees' cognitive abilities, disrupted detoxification enzymes, and increased oxidative stress markers. The study suggests that current risk assessments, which typically evaluate pesticides individually, may underestimate the real-world dangers bees face from chemical mixtures.
Influence of nano-polystyrene on cyfluthrin toxicity in honeybee Apis cerana cerana Fabricius
Researchers found that nano-polystyrene plastics damaged the gut and gland development of Asian honeybees, while also changing how the bees process toxins at the genetic level. When combined with the pesticide cyfluthrin, the nanoplastics altered detoxification and immune gene activity in complex ways. Since honeybees are essential pollinators for food crops, the toxic effects of nanoplastics on bee health could have indirect consequences for human food security.
Pesticides, Herbicides and Their Effects on Pollinators
This review examined how pesticide exposure—particularly neonicotinoids—harms pollinators through direct contact, ingestion, and bioaccumulation, finding that chronic low-level exposure impairs foraging, navigation, immune function, and reproduction in bees and other pollinators.
Effect of chronic deltamethrin exposure on brain transcriptome and metabolome of juvenile crucian carp
Researchers examined the effects of chronic deltamethrin exposure on the brain chemistry and gene expression of juvenile crucian carp. The study found that this common pyrethroid insecticide disrupted brain metabolic pathways and altered gene transcription patterns, suggesting potential neurotoxic effects on freshwater fish from ongoing pesticide contamination.
Single and Synergistic Effects of Microplastics and Difenoconazole on Oxidative Stress, Transcriptome, and Microbiome Traits in Honey Bees
Researchers exposed honey bees to microplastics and the fungicide difenoconazole, both alone and together, and found that the combination caused worse oxidative stress and gut microbiome disruption than either pollutant alone. This is concerning because bees encounter both pollutants in agricultural environments, and the combined exposure may weaken their health more than expected.
Binary combined toxicity of neonicotinoids and co-existing pollutants to non-target invertebrates: A meta-analysis
This global meta-analysis of 47 studies synthesized data on how co-exposure to neonicotinoid insecticides with other pollutants — including microplastics, heavy metals, and fungicides — affects non-target invertebrates, finding that co-contaminants generally amplify neonicotinoid toxicity especially for bees and aquatic invertebrates. The results highlight that real-world mixture exposures pose greater risks to invertebrate health than single-chemical laboratory studies suggest.
Current Knowledge on Bee Innate Immunity Based on Genomics and Transcriptomics
This review synthesized genomic and transcriptomic studies on innate immunity in bees, covering defense mechanisms against pathogens including viruses, bacteria, and parasites. The authors identified key immune genes and signaling pathways across solitary and social bee species, with implications for understanding colony health and designing interventions against bee population decline.
Microplastics reach the brain and interfere with honey bee cognition
Researchers found that microplastics reach honey bee brains and impair cognitive function, with bees exposed to mixed polymer combinations showing disrupted learning and memory abilities, demonstrating that plastic pollution poses a direct threat to pollinator health.
Gut microbiota analysis of the western honeybee ( Apis mellifera L.) infested with the mite Varroa destructor reveals altered bacterial and archaeal community
Researchers used 16S rRNA amplicon sequencing to characterize bacterial and archaeal gut communities in adult honeybees (Apis mellifera) and larvae from Varroa destructor-infested hives, comparing healthy and mite-affected groups. They found Bombella dominated larval microbiota while Gillamella, Lactobacillaceae, and Snodgrassella dominated adults, though healthy and Varroa-affected adult groups did not differ statistically, and larvae showed enrichment of genes involved in cofactor and vitamin biosynthesis.
Synergistic effects between microplastics and glyphosate on honey bee larvae
This study found that honey bee larvae exposed to microplastics combined with the herbicide glyphosate experienced worse developmental problems, higher oxidative stress, and stronger immune responses than those exposed to either pollutant alone. The combined exposure disrupted key detoxification and antioxidant genes in the developing bees. While focused on bees, this research highlights how microplastics can amplify the harm from other environmental chemicals, a pattern that likely applies to other organisms including humans.
Deciphering Pesticide Stress Responses in Rice Through Integrated Multi-Omic Assessment
This review synthesizes research on how pesticide exposure affects rice plants at the molecular level, drawing on transcriptomic, proteomic, and metabolomic studies. Researchers found that pesticides trigger detoxification enzymes, alter antioxidant defenses, and reprogram metabolic pathways in rice. The study highlights how integrating multiple omics approaches can provide a more complete picture of pesticide stress responses in crops.
Impact of Oxytetracycline on Apis mellifera Colonies: Preliminary Results on Residues and Antibiotic Resistance
Researchers conducted a preliminary study testing two oxytetracycline (OTC) administration protocols (long and short) on 18 honeybee (Apis mellifera) colonies divided into three groups to assess toxicity, honey residues, and antibiotic resistance gene transfer. They found no toxicity to adult bees or brood but detected OTC residues in nest honey up to seven months post-treatment (210.3 micrograms/kg after long protocol) and identified genes encoding OTC antibiotic resistance in bacteria isolated from adult bee guts.
A global meta-analysis reveals the toxicity of plastics on insect health
This meta-analysis pools data from global studies to reveal that microplastics and nanoplastics are harmful to insect health, affecting survival, reproduction, and development. Since insects play critical roles in pollination and food chains, their decline from plastic pollution could have cascading effects on agriculture and the broader ecosystems humans depend on.
Suborganismal responses of the aquatic midge Chironomus riparius to polyethylene microplastics
Researchers exposed Chironomus riparius larvae to polyethylene microplastics and used transcriptomics and metabolomics to characterize suborganismal responses, finding disruption of oxidative stress pathways, energy metabolism, and cuticle synthesis — effects not captured by standard life-history endpoints alone.
The Negligible Effect of Toxic Metal Accumulation in the Flowers of Melliferous Plants on the Mineral Composition of Monofloral Honeys
Researchers found that while melliferous plants like dandelion and goldenrod accumulate cadmium and lead from contaminated soil, toxic metals were not meaningfully transferred into monofloral honeys, suggesting honeybees act as effective biofilters that protect the nutritional quality of honey.
Hazard Assessment of the Effects of Acute and Chronic Exposure to Permethrin, Copper Hydroxide, Acephate, and Validamycin Nanopesticides on the Physiology of Drosophila: Novel Insights into the Cellular Internalization and Biological Effects
Researchers assessed the toxicity and genotoxicity of four nanopesticide formulations (permethrin, copper hydroxide, acephate, and validamycin) to Drosophila melanogaster through acute and chronic exposure, finding that all four caused physiological and genetic damage at relevant concentrations. The study revealed cellular internalization pathways and highlighted the need for nanopesticide-specific safety evaluation frameworks.
Low doses of imidacloprid induce disruption of intercellular adhesion and initiate proinflammatory changes in Caco-2 cells
Low doses of the neonicotinoid insecticide imidacloprid disrupted intercellular junction proteins and triggered pro-inflammatory signaling in Caco-2 intestinal epithelial cells, suggesting that even sub-lethal pesticide exposure can impair gut barrier integrity and initiate intestinal inflammation relevant to human health.
Toxicogenomic Fingerprint Identification in Springtails to Assess Pesticide-Contaminated Soils
Researchers used toxicogenomic fingerprinting in springtails (Collembola) to assess the effects of pesticide-contaminated soils, analyzing gene expression patterns to identify molecular signatures of pesticide exposure in these ecologically important soil invertebrates. The approach identified distinct transcriptomic responses linked to specific pesticide classes, offering a sensitive biomonitoring tool for evaluating soil contamination in agricultural landscapes.
Glyphosate and Glufosinate Residues in Honey and Other Hive Products
This review examined the presence of glyphosate, glufosinate, and their metabolites in honey and other hive products, highlighting contamination pathways from agricultural herbicide use and potential risks to bee and human health.
Preliminary data on glyphosate, glufosinate, and metabolite contamination in Italian honey samples
Researchers tested 30 honey samples from Italian retailers for glyphosate and glufosinate herbicide residues. They found measurable glyphosate in eight samples, with one wildflower honey containing nearly three times the legal maximum residue limit. The study raises concerns about pesticide contamination reaching consumers through bee products and highlights the need for continued monitoring.
Climate change, air pollution, and risks to honeybees – a review of biomonitoring data
Not relevant to microplastics — this review synthesizes global biomonitoring data on honeybee exposure to metals, PAHs, pesticides, and other environmental pollutants, assessing bees as sentinel species for ecosystem health under climate change.
Stimulation of insect vectors of pathogens by sublethal environmental contaminants: A hidden threat to human and environmental health?
Researchers reviewed evidence showing that sublethal doses of environmental contaminants, including microplastics and pesticides, can stimulate rather than inhibit insect disease vectors such as mosquitoes and agricultural pests. The study suggests these hormetic responses could enhance pathogen transmission and disease spread, representing an underappreciated threat to public health and food security that warrants further investigation.