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Papers
20 resultsShowing papers similar to Metabolomics-Based Analysis of the Major Taste Contributors of Meat by Comparing Differences in Muscle Tissue between Chickens and Common Livestock Species
ClearMetabolic disruption of flavor substance in aquatic animals: a review of POPs and heavy metal effects
This review examines the effects of persistent organic pollutants and heavy metals on key flavor substances in aquatic animals, including free amino acids, nucleotides, and organic acids that determine the taste of aquatic products. The authors found that marine pollutant stress disrupts the metabolic stability of these flavor compounds, with implications for both aquatic animal health and seafood quality.
Cross-Platform Comparison of Amino Acid Metabolic Profiling in Three Model Organisms Used in Environmental Metabolomics
Researchers compared NMR and mass spectrometry for amino acid profiling in three model organisms, finding significant platform-dependent differences for environmental studies.
Metabolites, gene expression and gut microbiota profiles suggest the putative mechanisms via which dietary creatine increases the serum taurine and g- ABA contents in Megalobrama amblycephala
Researchers investigated the effects of dietary creatine and betaine supplementation on growth performance, liver health, serum metabolites, gene expression, and gut microbiota in blunt snout bream (Megalobrama amblycephala) fed high-carbohydrate diets, finding that combined creatine-betaine supplementation improved feed conversion and liver health compared to high-carbohydrate controls.
Detection of the Disorders of Glycerophospholipids and Amino Acids Metabolism in Lung Tissue From Male COPD Patients
Untargeted metabolomics was applied to lung tissue from male COPD patients to characterize metabolic disruptions, finding significant disturbances in glycerophospholipid and amino acid metabolism compared to healthy controls. The study identifies overlapping biomarkers between lung tissue and plasma metabolomes, suggesting that blood-based metabolic profiling could serve as a surrogate for lung metabolic status in COPD.
Untargeted Metabolomics Uncovers Food Safety Risks: Polystyrene Nanoplastics Induce Metabolic Disorders in Chicken Liver
Researchers exposed chickens to polystyrene nanoplastics through feed for 120 days and used metabolomics to assess the impact on liver health. They found significant liver damage, including increased lipid accumulation and elevated liver enzyme levels, along with disruption of 193 metabolites primarily related to lipid and amino acid metabolism. The study raises food safety concerns, suggesting that nanoplastic contamination in poultry feed could affect the quality and safety of poultry products entering the food chain.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Predicting Valproate-Induced Liver Injury Using Metabolomic Analysis of Ex Ovo Chick Embryo Allantoic Fluid
This paper is not about microplastics; it evaluates chick embryo allantoic fluid metabolomics as a model for predicting drug-induced liver injury from valproate.
Characterization of Botanical Parts of Erythrina crista-galli Using Pyrolysis-Gas Chromatography/Mass Spectrometry and Multivariate Analysis
Researchers characterised the chemical composition of five botanical parts of Erythrina crista-galli (bark, flowers, leaves, roots, and twigs) using pyrolysis-gas chromatography/mass spectrometry combined with principal component analysis and hierarchical cluster analysis. The multivariate analysis clustered the botanical parts into three groups based on chemical similarity and identified lignin G content as the primary differentiating factor, with roots showing the highest relative lignin G abundance.
Microplastics: a potential threat to gut microbiota and antioxidant capacity of broiler chickens
Researchers investigated the effects of microplastic exposure on broiler chickens and found significant increases in liver enzyme and oxidative stress markers alongside decreased antioxidant capacity. The study also revealed substantial disruption to gut microbiota, with reduced diversity and altered microbial community structure affecting energy metabolism, amino acid metabolism, and other key functions.
Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis
Researchers fed chickens different doses of polystyrene microplastics and used multi-omics analysis to study digestive system damage through the gut-liver axis. They found that microplastics disrupted gut barrier function, altered liver metabolism, and changed gut bacterial communities in a dose-dependent manner. The study provides detailed molecular evidence of how microplastics can damage the digestive health of poultry, which may have implications for food safety.
Comparative Metabolomic Approaches to Nanoplastic Toxicity in Mammalian and Aquatic Systems
This review compared metabolomic approaches used to characterize nanoplastic toxicity across mammalian and aquatic biological systems, synthesizing data on oxidative stress, mitochondrial dysfunction, and metabolic pathway disruption. The authors found convergent metabolic signatures—particularly in amino acid and lipid metabolism—across diverse organisms, suggesting common toxicological mechanisms regardless of species.
Exposure to known and emerging groundwater contaminants significantly alters poultry microbiome and metabolome
Researchers exposed broiler chickens to low-level mixtures of agricultural chemicals and microplastics via contaminated groundwater and found that gut microbial communities and metabolic pathways were significantly altered — including disrupted energy metabolism and cofactor availability — without observable intestinal damage, revealing a form of subclinical dysbiosis.
Mass Spectrometry Imaging Disclosed Spatial Distribution of Defense-Related Metabolites in Triticum spp.
Mass spectrometry imaging was used to map the spatial distribution of defense-related metabolites in two Triticum wheat species infected with Fusarium head blight, revealing tissue-specific locations of the metabolic response to mycotoxin challenge.
Relevance of gut microbiome research in food safety assessment
This review examined how the gut microbiome metabolizes non-nutritious dietary compounds, arguing that gut microbial processing of food contaminants and additives is an underappreciated dimension of food safety assessment.
Genome-Wide Structural Variation Analysis and Breed Comparison of Local Domestic Ducks in Shandong Province, China
Researchers mapped the structural variations in the genomes of three domestic duck breeds from Shandong Province, China, identifying over 21,000 variants linked to traits like nervous system development, energy metabolism, and reproduction. Population analysis revealed distinct genetic profiles among the breeds, with geographic isolation contributing to greater genetic uniformity in one breed. The findings provide a genetic foundation for selective breeding and the development of new duck breeds.
Effects of blended microbial feed additives on performance, meat quality, gut microbiota and metabolism of broilers
Researchers evaluated the effects of supplementing diets of 240 Wenchang broilers with blended microbial feed additives at 0, 0.2, 0.4, and 0.6 percent concentrations over 70 days, measuring outcomes including growth performance, meat quality, gut microbiota composition, and metabolic parameters.
Toxicity mechanisms of polystyrene microplastics in marine mussels revealed by high-coverage quantitative metabolomics using chemical isotope labeling liquid chromatography mass spectrometry
Scientists used an advanced metabolomics technique to study how polystyrene microplastics affect marine mussels at the molecular level, identifying nearly 3,600 metabolic compounds. The study found that microplastics at environmentally realistic concentrations disrupted amino acid metabolism, leading to oxidative stress and immune system effects. Encouragingly, after a week-long recovery period, the mussels largely returned to normal, suggesting these toxic effects may be reversible.
Xenovolatilomic profiling of Hass avocado ( Persea americana Mill.) tissues exposed to endosulfan: identification of potential toxicity biomarkers
Researchers applied xenovolatilomic profiling using GC-MS to identify potential toxicity biomarkers in Hass avocado tissues exposed to the pesticide endosulfan. The study explored biochemical alterations through volatile organic compound profiling, offering insights into how persistent organic pollutants affect plant biochemistry.
Critical features of an in vitro intestinal absorption model to study the first key aspects underlying food allergen sensitization
This study identified critical design features for in vitro intestinal absorption models to study food allergen sensitization, providing a framework for screening novel protein sources — including insect proteins and other alternative foods — for allergic risk.
Species Sensitivity to Toxic Substances: Evolution, Ecology and Applications
This review explores why different species vary in their sensitivity to toxic substances, examining the evolutionary and ecological factors that drive these differences. Researchers analyzed how traits like metabolic capacity, body size, and life history influence how organisms respond to chemical exposure. The study provides a framework for improving ecotoxicological predictions by better understanding the biological basis of species sensitivity.