Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Detection Methods Human Health Effects Marine & Wildlife Sign in to save

Toxicity mechanisms of polystyrene microplastics in marine mussels revealed by high-coverage quantitative metabolomics using chemical isotope labeling liquid chromatography mass spectrometry

Journal of Hazardous Materials 2021 136 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Wei Huang, Wei Huang, Xinghuo Wang, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Wei Huang, Youji Wang Wei Huang, Wei Huang, Youji Wang Elvis Genbo Xu, Wei Huang, Wei Huang, Elvis Genbo Xu, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Wei Huang, Elvis Genbo Xu, Elvis Genbo Xu, Xinghuo Wang, Xinghuo Wang, Wei Huang, Wei Huang, Wei Huang, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Deying Chen, Jiangning Zeng, Xinghuo Wang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Youji Wang Youji Wang Wei Huang, Youji Wang Youji Wang Xinghuo Wang, Elvis Genbo Xu, Elvis Genbo Xu, Wei Huang, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Wei Huang, Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Wei Huang, Elvis Genbo Xu, Elvis Genbo Xu, Wei Huang, Elvis Genbo Xu, Wei Huang, Wei Huang, Wei Huang, Xinghuo Wang, Wei Huang, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Wei Huang, Xinghuo Wang, Jiangning Zeng, Jiangning Zeng, Jiangning Zeng, Xian Luo, Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Wei Huang, Wei Huang, Wei Huang, Wei Huang, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Xinghuo Wang, Youji Wang Wei Huang, Jiangning Zeng, Wei Huang, Youji Wang Wei Huang, Jiangning Zeng, Youji Wang Youji Wang Wei Huang, Wei Huang, Jiangning Zeng, Elvis Genbo Xu, Wei Huang, Wei Huang, Youji Wang Wei Huang, Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Wei Huang, Elvis Genbo Xu, Elvis Genbo Xu, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Youji Wang Tao Huan, Youji Wang Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Elvis Genbo Xu, Wei Huang, Wei Huang, Youji Wang Youji Wang Youji Wang Liang Li, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Wei Huang, Wei Huang, Elvis Genbo Xu, Elvis Genbo Xu, Wei Huang, Youji Wang Xinghuo Wang, Youji Wang Jiangning Zeng, Wei Huang, Youji Wang Youji Wang Youji Wang Wei Huang, Wei Huang, Xinghuo Wang, Elvis Genbo Xu, Jiangning Zeng, Wei Huang, Wei Huang, Youji Wang Wei Huang, Elvis Genbo Xu, Youji Wang Elvis Genbo Xu, Wei Huang, Wei Huang, Youji Wang Youji Wang Youji Wang Youji Wang Wei Huang, Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Youji Wang Elvis Genbo Xu, Jiangning Zeng, Wei Huang, Wei Huang, Youji Wang Elvis Genbo Xu, Youji Wang Youji Wang Liang Li, Youji Wang Youji Wang

Summary

Scientists used an advanced metabolomics technique to study how polystyrene microplastics affect marine mussels at the molecular level, identifying nearly 3,600 metabolic compounds. The study found that microplastics at environmentally realistic concentrations disrupted amino acid metabolism, leading to oxidative stress and immune system effects. Encouragingly, after a week-long recovery period, the mussels largely returned to normal, suggesting these toxic effects may be reversible.

Polymers

Body Systems

Immune Nervous

Models

Invertebrate other

Marine microplastic has become an important environmental issue of global concern due to its wide distribution and harmful impacts. However, there is still insufficient information on the toxicity mechanism of microplastics to marine organisms. In this study, we developed and applied a high-coverage quantitative metabolomics technique to investigate the toxicity mechanisms of the polystyrene microspheres (micro-PS) on marine mussels (Mytilus coruscus). A total of 3599 metabolites were quantified, including 163 positively identified metabolites, 318 high-confident putatively identified metabolites, and 2602 mass-matched metabolites from the hemolymph of mussels. Metabolomics analysis indicated that micro-PS disrupted the amino acid metabolism, particularly phenylalanine metabolism, which may lead to oxidative stress and neurotoxicity. Micro-PS at environmentally relevant concentrations induced oxidative stress and immunotoxicity in mussels. After 7 days of recovery, along with the significant clearance of micro-PS by mussels, both metabolite levels and biochemical indicators generally returned to the same level as the control group. Overall, the results showed that microplastics at environmentally-relevant concentrations can cause toxic effects on mussels but these influences are reversible. We envisage the usages of high-coverage metabolomics for investigating the toxicity of various types of microplastics under many different conditions, including those relevant to the marine environment.

Read via DOI PubMed

Share this paper

Post Share Share Pin Email