Papers

61,005 results
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Article Tier 2

Role of nanoparticle surface charge in their toxicity

This study examined how surface charge (carboxyl vs. amino functionalization) affects the toxicity of polystyrene nanoparticles formed during plastic degradation, noting that nanoparticle toxicity can differ substantially from bulk material. Results highlighted that surface chemistry is a critical determinant of nanoparticle behavior in biological environments.

2024 E3S Web of Conferences 1 citations
Article Tier 2

Long-term toxicity of surface-charged polystyrene nanoplastics to marine planktonic species Dunaliella tertiolecta and Artemia franciscana

Researchers conducted long-term toxicity tests of positively and negatively charged polystyrene nanoparticles on marine microalgae and brine shrimp, finding that surface chemistry was the decisive factor: cationic (amino-modified) nanoparticles caused algal growth inhibition and shrimp mortality at microgram-per-liter concentrations, while anionic (carboxylated) particles accumulated and transferred trophically without acute lethality.

2017 Aquatic Toxicology 412 citations
Article Tier 2

Effects of polystyrene microplastics on early stages of two marine invertebrates with different feeding strategies

Researchers exposed early life stages of two marine invertebrates to polystyrene microplastics to measure effects on development and survival. The study found that even early life stages are vulnerable to microplastic exposure, raising concerns about impacts on marine invertebrate populations.

2017 Environmental Pollution 191 citations
Article Tier 2

Accumulation and Embryotoxicity of Polystyrene Nanoparticles at Early Stage of Development of Sea Urchin Embryos Paracentrotus lividus

Researchers exposed sea urchin embryos to polystyrene nanoparticles with different surface charges and studied how the particles accumulated and affected development. They found that positively charged nanoparticles embedded in the embryos' outer membrane and caused significant developmental defects, while negatively charged particles were less harmful. The study suggests that the surface chemistry of nanoplastics plays a key role in determining their toxicity to developing marine organisms.

2014 Environmental Science & Technology 610 citations
Article Tier 2

Differential toxicity of functionalized polystyrene microplastics to clams (Meretrix meretrix) at three key development stages of life history

Carboxylated and amino-functionalized polystyrene microplastics were tested on clam larvae at three developmental stages (fertilized eggs, D-veliger, umbo larvae), with both plastic types decreasing hatching rates (5.79–39.5%) and developmental rates (4.78–7.86%), and toxicity being greatest at the earliest stage. The study reveals that clam larvae are most vulnerable to functionalized microplastics during fertilization and early development, with surface charge playing a key role in toxicity.

2019 Marine Pollution Bulletin 83 citations
Article Tier 2

Polystyrene Nanoplastic Behavior and Toxicity on Crustacean Daphnia magna: Media Composition, Size, and Surface Charge Effects

Researchers examined how size and surface charge of polystyrene nanoplastics (20-100 nm) affected their behavior and toxicity to Daphnia magna in different water media, finding that smaller particles and certain media compositions significantly increased toxicity and aggregation patterns.

2021 Environments 34 citations
Article Tier 2

A Multisystemic Approach Revealed Aminated Polystyrene Nanoparticles-Induced Neurotoxicity.

Aminated polystyrene nanoparticles caused neurotoxicity in multiple model systems, including effects on neuronal cell viability, oxidative stress markers, and behavioral changes in exposed organisms, demonstrating that surface charge of nanoplastics influences their capacity to damage nervous tissue.

2024 Small (Weinheim an der Bergstrasse, Germany)
Article Tier 2

Charge-dependent negative effects of polystyrene nanoplastics on Oryzias melastigma under ocean acidification conditions

This study tested the combined effects of differentially charged polystyrene nanoplastics and ocean acidification on the marine fish Oryzias melastigma, finding that surface charge significantly influenced both independent and interactive toxicity. Negatively charged particles were generally more harmful, with effects exacerbated under acidified conditions.

2022 The Science of The Total Environment 14 citations
Review Tier 2

Micro- and nanoplastic toxicity: A review on size, type, source, and test-organism implications

This comprehensive review analyzed 615 studies on the toxicity of micro- and nanoplastics across different polymer types, sizes, and organisms. A major finding is that over 90% of nanoplastic research uses only polystyrene, leaving huge gaps in our understanding of other common plastics at the nanoscale. The review highlights that smaller particles are generally more toxic and that more research is urgently needed on the nanoplastics people are most likely to encounter in everyday life.

2023 The Science of The Total Environment 149 citations
Article Tier 2

Review of the toxic effects and mechanisms of polystyrene micro/nanoplastics across multiple animal species

This review comprehensively examines the toxic effects of polystyrene micro- and nanoplastics across marine animals, freshwater species, soil organisms, and mammals. Researchers found that these particles can cause damage at multiple biological levels, affecting the digestive, respiratory, nervous, reproductive, and circulatory systems. The study highlights the widespread environmental presence of polystyrene plastics and the need to better understand how they harm living organisms.

2025 Journal of Hazardous Materials Advances 2 citations
Article Tier 2

Nanoplastics in the oceans: Theory, experimental evidence and real world

Researchers critically review over 200 studies on nanoplastic pollution — focusing predominantly on polystyrene — synthesizing knowledge on how nanoplastics form from polymer degradation, accumulate in seawater, and affect organisms in controlled conditions, while identifying key methodological standards needed for reliable ecotoxicological assessments.

2020 Marine Pollution Bulletin 84 citations
Article Tier 2

Effect of salinity and humic acid on the aggregation and toxicity of polystyrene nanoplastics with different functional groups and charges

Researchers showed that surface charge governs nanoplastic behavior in water — higher salinity caused negatively charged nanoplastics to aggregate while positively charged particles remained stable — and that humic acid (dissolved organic matter) alleviated toxicity to Daphnia, increasing survival from 15% to nearly 100% in some cases.

2018 Environmental Pollution 289 citations
Article Tier 2

Investigating the toxicities of different functionalized polystyrene nanoplastics on Daphnia magna

Researchers compared the toxicity of plain and surface-modified polystyrene nanoplastics on Daphnia water fleas, finding that unmodified particles were most lethal by activating stress kinase pathways, while surface-functionalized particles were less toxic — largely because positively charged particles aggregated rapidly in water and reduced their effective exposure concentration.

2019 Ecotoxicology and Environmental Safety 154 citations
Article Tier 2

Impact of nano- and micro-sized polystyrene beads on larval survival and growth of the Pacific oyster Crassostrea gigas.

Polystyrene beads at nano (0.55 um) and micro (10, 100 um) sizes were tested on Pacific oyster larvae, with smaller particles causing greater mortality and growth inhibition at lower concentrations, suggesting nanoplastics pose a higher risk to early bivalve development than microplastics.

2024 Journal of hazardous materials
Article Tier 2

Nano-sized polystyrene affects feeding, behavior and physiology of brine shrimp Artemia franciscana larvae

Researchers exposed brine shrimp larvae to anionic and cationic polystyrene nanoparticles and found sub-lethal but significant effects: anionic particles packed guts and limited feeding, while positively charged particles adhered to sensory appendages, impaired movement, and triggered repeated molting as a possible expulsion defense.

2015 Ecotoxicology and Environmental Safety 361 citations
Article Tier 2

Acute toxicity of nanoplastics on Daphnia and Gammarus neonates: Effects of surface charge, heteroaggregation, and water properties

Researchers examined nanoplastic toxicity on crustacean neonates and found that smaller particles (20-40 nm) were more toxic, with surface charge and aggregation behavior being the primary factors influencing toxicity depending on species and water conditions.

2022 The Science of The Total Environment 22 citations
Article Tier 2

Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next

This review integrates findings from studies on how polystyrene nanoplastics affect zebrafish embryo development, a widely used model for understanding toxicity. Researchers found that the functional coating on nanoplastic surfaces had a greater influence on toxic effects than particle size or concentration alone. The study highlights that surface chemistry is a critical and often overlooked factor in nanoplastic toxicity, and calls for more standardized study designs to improve comparability across research.

2021 The Science of The Total Environment 105 citations
Article Tier 2

Sublethal Effects of Polystyrene Nanoplastics on the Embryonic Development of Artemia salina (Linnaeus, 1758)

Researchers exposed brine shrimp embryos to amino-modified polystyrene nanoplastics of two sizes and assessed a range of developmental effects. They found that the nanoplastics accumulated in the organisms and caused sublethal effects including altered hatching rates and developmental abnormalities, even at non-lethal concentrations. The study suggests that nanoplastic pollution may pose risks to the early development of organisms at the base of aquatic food chains.

2023 Animals 15 citations
Article Tier 2

What Is on the Outside Matters—Surface Charge and Dissolve Organic Matter Association Affect the Toxicity and Physiological Mode of Action of Polystyrene Nanoplastics toC. elegans

Researchers investigated how surface charge and organic matter coatings affect the toxicity of polystyrene nanoplastics to the nematode C. elegans. Positively charged nanoplastics were over 60 times more toxic than negatively charged ones, and organic matter coatings reduced toxicity across all particle types. The findings suggest that surface chemistry plays a critical role in nanoplastic toxicity and should be considered when assessing environmental risks.

2021 Environmental Science & Technology 79 citations
Article Tier 2

Ecotoxicological Effects of Nanoplastic and Microplastic Polystyrene Particles on Hyalella azteca: A Comprehensive Study on the Impact of Physical and Chemical Surface Properties

Researchers studied the ecotoxicological effects of polystyrene nano- and microplastics on the freshwater crustacean Hyalella azteca through short- and long-term exposure experiments. The study found that surface properties and functional group modifications of the particles were key determinants of toxicity, with amino-functionalized microplastics and fluorescent nanoplastics showing significant effects on oxidative stress biomarkers and organism development, while unmodified nanoplastics were nearly inert.

2025 Journal of Contaminant Hydrology 1 citations
Article Tier 2

Functionalized polystyrene nanoplastic-induced energy homeostasis imbalance and the immunomodulation dysfunction of marine clams (Meretrix meretrix) at environmentally relevant concentrations

Functionalized polystyrene nanoplastics inhibited growth of marine clams (Meretrix meretrix) at environmentally relevant concentrations by disrupting energy homeostasis and immune function. The study demonstrated that surface functionalization of nanoplastics influences their toxicity to filter-feeding bivalves.

2021 Environmental Science Nano 54 citations
Article Tier 2

Developmental toxicity of functionalized polystyrene microplastics and their inhibitory effects on fin regeneration in zebrafish

Researchers exposed zebrafish to polystyrene microplastics with different surface modifications and found that all types caused developmental toxicity, including increased mortality, reduced body length, and impaired swimming ability. The amino-modified particles were generally the most harmful, also inhibiting fin regeneration after injury. The study suggests that surface chemistry plays a critical role in determining how microplastics interact with biological systems.

2025 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 1 citations
Article Tier 2

Cytotoxic effects of polystyrene nanoplastics with different surface functionalization on human HepG2 cells

Researchers exposed human liver (HepG2) cells to 50 nm polystyrene nanoparticles with three different surface chemistries and found that amino-functionalized particles caused the greatest cytotoxicity and oxidative stress, demonstrating that surface charge and chemistry — not just particle size — determine nanoplastic harm to human cells.

2020 The Science of The Total Environment 211 citations
Article Tier 2

Nanopolystyrene beads affect motility and reproductive success of oyster spermatozoa (Crassostrea gigas)

Polystyrene nanoplastics with positively charged surfaces caused dramatic reductions in oyster sperm motility and fertilization success at relatively low concentrations, while negatively charged particles only affected motility at higher doses. The study raises concerns about how nanoplastic surface chemistry affects reproductive success in commercially important marine species.

2020 Nanotoxicology 45 citations