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20 resultsShowing papers similar to Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
ClearThe quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Novel application of microparticles demonstrate myeloid uptake and induce phenotypic change within the brain tumor microenvironment 2254
Researchers demonstrated that microparticles can be taken up by myeloid cells within glioblastoma tumors and can induce phenotypic changes in tumor-associated macrophages and neutrophils, suggesting that particle-based approaches may be able to modify the immunosuppressive tumor microenvironment.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.
Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations
This review examines three cutting-edge approaches to cancer treatment: nanomaterials for targeted drug delivery, mesenchymal stem cells as carriers for therapeutic agents, and microbial agents that can selectively attack tumors. Each approach aims to overcome the limitations of conventional treatments like chemotherapy and radiation, which often damage healthy tissue and lead to drug resistance. The authors discuss both the promise and the remaining challenges of bringing these innovative therapies into clinical practice.
Extracellular Vesicles & Co.: scaring immune cells in the TME since ever
This review explores how extracellular vesicles and other secreted particles in the tumor microenvironment help cancer cells evade the immune system. Researchers described the various ways these tiny cell-derived packages carry signals that suppress immune responses and promote tumor growth. The study provides a broad overview of how intercellular communication in tumors undermines the body's natural defenses against cancer.
The influence of microplastic particles on the effectiveness of electrochemotherapy in breast cancer cells
Researchers examined whether microplastic particle exposure affects the effectiveness of electrochemotherapy in breast cancer cells, investigating whether MPs could alter cellular responses to the combined electroporation and chemotherapy treatment through inflammatory or oxidative stress mechanisms.
Effects of Combination Treatments with Astaxanthin-Loaded Microparticles and Pentoxifylline on Intracellular ROS and Radiosensitivity of J774A.1 Macrophages.
This study examined how astaxanthin-loaded microparticles combined with a drug affected reactive oxygen species levels and radiation sensitivity in immune cells. This is a cancer treatment research study with no direct connection to environmental microplastics.
IL-11-Engineered Macrophage Membrane-Coated Reactive Oxygen Species-Responsive Nanoparticles for Targeted Delivery of Doxorubicin to Osteosarcoma
Researchers designed reactive oxygen species-responsive nanoparticles coated with interleukin-11-engineered macrophage membranes for targeted doxorubicin delivery to osteosarcoma tumors in children and adolescents. The biomimetic nanocarriers evaded immune clearance and selectively accumulated at tumor sites, improving chemotherapy delivery efficiency in preclinical models.
Tumour-associated macrophages: versatile players in the tumour microenvironment
This review explores tumour-associated macrophages, immune cells that play complex and sometimes contradictory roles in cancer, both helping tumours grow and fighting them. Researchers describe newly discovered behaviors of these cells, including their ability to transform into other cell types. The study highlights the potential of targeting these macrophages as a strategy in cancer immunotherapy.
Exploring Metal Nanoparticles Interaction with Cancer Cells
This paper is not relevant to microplastics research — it reviews the uses of metal nanoparticles in biomedical applications, particularly cancer treatment, and discusses their toxicity profiles.
Nanoplastics Shape Adaptive Anticancer Immunity in the Colon in Mice
In a mouse study, researchers found that orally administered polyethylene nanoplastics disrupted the intestinal immune environment in ways that could favor tumor growth in the colon. The nanoplastics altered immune cell populations and promoted an immunosuppressive environment around colorectal tumors. The study suggests that nanoplastic exposure may influence how the immune system responds to abnormal cell growth in the gut.
A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells
This study developed nanoparticle-based technology to treat aggressive brain tumors (glioblastoma) by penetrating deep into tumor tissue and activating the immune system against cancer cells. While not directly about microplastic pollution, it demonstrates that nanoparticles can cross brain barriers and influence immune responses. The research is relevant because it shows how tiny particles, including plastics, can access and affect the brain.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Iron Oxide Nanoparticles: Selectively Targeting Melanoma Cells In Vitro by Inducing DNA Damage via H2AX Phosphorylation and Hindering Proliferation through ERK Dephosphorylation
Researchers investigated iron oxide magnetic nanoparticles and found they selectively target melanoma cancer cells while sparing healthy skin cells. The nanoparticles triggered DNA damage and blocked cell growth signals specifically in melanoma cells, and their effectiveness was further enhanced using magnetic heating. The study explores a nanotechnology-based approach to cancer treatment rather than microplastic-related research.
Intratumoural microbiota: from theory to clinical application
Researchers reviewed how bacteria living inside tumors — called intratumoural microbiota — influence cancer development, immune responses, and treatment outcomes. They highlight that while some tumor-resident microbes drive cancer progression by damaging DNA and disrupting immune signaling, engineered bacteria could be harnessed as novel therapeutic tools to target tumors directly.
The ancillary effects of nanoparticles and their implications for nanomedicine
Researchers reviewed 'ancillary effects' — the unintended biological interactions between nanoparticles and living systems that occur independent of engineered targeting or therapeutic functions — cataloguing how nanomaterial surface properties can modulate cell signaling, immune responses, and toxicity in ways that have major implications for nanomedicine safety and design.
Role of microplastics in the tumor microenvironment (Review)
This review examines how microplastics may help tumors grow by influencing the environment around cancer cells. Microplastics can interact with immune cells, connective tissue cells, blood vessel cells, and the tissue scaffolding around tumors in ways that may promote cancer progression and inflammation. While more research is needed, the findings raise important questions about whether chronic microplastic exposure could affect cancer development in humans.
The Immunotoxic Effects of Environmentally Relevant Micro- and Nanoplastics
Researchers characterized the immunotoxic effects of over 20 types of micro- and nanoplastic particles on macrophages and dendritic cells, finding that physicochemical properties such as size, shape, polymer type, and surface oxidation strongly influence immune cell responses.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.