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Papers
20 resultsShowing papers similar to Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models
ClearOral Exposure to Epoxiconazole Disturbed the Gut Micro-Environment and Metabolic Profiling in Male Mice
Researchers found that oral exposure to the fungicide epoxiconazole disrupted gut microbiota composition and metabolic profiling in male mice, altering intestinal barrier function and mucus secretion with implications for gut health.
Capturing and Quantifying Particle Transcytosis with Microphysiological Intestine‐on‐Chip Models
A microphysiological intestinal model was used to quantify how nano- and microparticles cross the gut epithelium by transcytosis, providing more realistic transport data than standard Caco-2 monolayer assays. The system revealed size-dependent transport efficiency with implications for both drug delivery optimization and health risk assessment of ingested particles.
Mathematical modeling of fluid dynamics in in vitro gut fermentation systems: A new tool to improve the interpretation of microbial metabolism
This study developed fluid dynamics models using ordinary differential equations to simulate how compounds move through in vitro gut fermentation systems, helping distinguish true microbial metabolism from physical dilution. The models were validated against two commonly used in vitro systems to improve interpretation of dietary compound fate studies.
Bioaccessibility of microplastic-associated heavy metals using an in vitro digestion model and its implications for human health risk assessment
Researchers evaluated the bioaccessibility of heavy metals associated with microplastics using an in vitro digestion model to assess human health risks. The study found significant adsorption of arsenic, chromium, cadmium, and lead onto polyvinyl chloride microplastics, with varying bioaccessibility across different digestive phases. The findings suggest that incorporating bioaccessibility data into risk assessments may provide more accurate estimates of health risks from ingesting microplastic-associated heavy metals.
Sub-Chronic Difenoconazole Exposure Induced Gut Microbiota Dysbiosis in Mice
Male mice exposed to the fungicide difenoconazole for 56 days at 30 and 100 mg/kg/day developed gut microbiota dysbiosis, with disrupted microbial community composition that may indicate risks to mammalian health from agricultural fungicide residues.
Copper adsorption on microplastics: Investigating toxicity in an in vitro digestive environment
Researchers analyzed how the presence of microplastics affects copper bioaccessibility and toxicity during in vitro digestion, testing naturally weathered particles as a realistic exposure model. Microplastics altered the bioaccessible fraction of copper, with implications for how co-ingested metals behave in the human gut.
Bioaccessibility of polypropylene microfiber-associated tetracycline and ciprofloxacin in simulated human gastrointestinal fluids
Researchers tested how antibiotics attached to polypropylene microplastic fibers behave when exposed to simulated human digestive fluids. They found that the antibiotics were released from the microplastics during digestion, with higher release rates in intestinal fluid than in stomach fluid. The study suggests that when people ingest microplastics contaminated with antibiotics, the chemicals can become available for absorption in the gut.
Copper adsorption on microplastics: Investigating toxicity in an in vitro digestive environment
Researchers investigated how the presence of naturally weathered microplastics affects the bioaccessibility and toxicity of adsorbed copper during simulated gastrointestinal digestion. Results showed that microplastics altered the release and uptake of copper in the gut, potentially increasing or decreasing its bioavailable fraction depending on conditions.
EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects
Researchers used new approach methodologies to assess the potential hazards of nanocellulose materials when consumed orally, focusing on intestinal barrier crossing, local tissue effects, and microbiome interactions. They found that nanocellulose particles were taken up by intestinal cells and that repeated exposure increased uptake, though most effects on gut tissue were mild. The study provides safety-relevant data for the growing use of nanocellulose in food industry applications.
Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro
Researchers found that surfactants added to agricultural pesticide formulations significantly increase the toxicity of the active ingredients by making it easier for them to cross cell membranes and blocking the body's normal chemical removal pathways. This suggests that pesticide safety testing should evaluate the complete formulation — not just the active ingredient — since the added chemicals can amplify harm in ways not currently captured by regulators.
Analysis of PFAS in Locally Acquired Food Containers
This paper is not relevant to microplastics research — despite its title referencing PFAS in food containers, the abstract describes methods for measuring intestinal permeability using sugar absorption tests.
Microplastics in our diet: complementary in vitro gut and epithelium models to understand their fate in the human digestive tract.
Researchers used complementary in vitro gut models to study how microplastics behave during human digestion, finding that digestive conditions alter microplastic surface properties and their interactions with gut cells. The work advances understanding of how ingested microplastics may affect the human digestive system.
Digestion of Polystyrene Nanoparticles in a Whey Protein Drink. a Simulated in Vitro Gastrointestinal Digestion Using a Batch Infogest Model Combined with Cell Absorption Experiments
This study tracked polystyrene nano- and microplastic particles through a simulated digestive process mixed with a whey protein drink, then tested whether the particles could be absorbed by human intestinal cells. The work contributes to understanding how dietary microplastics survive digestion and whether they can pass through the gut lining into the body.
Cell-Based In Vitro Models: Emerging Technologies for Enhanced Drug Permeability Prediction
This paper is not about microplastics. It reviews cell-based laboratory models used to predict how well drugs are absorbed through biological barriers like the gut, lung, and skin. While drug permeation research is relevant to understanding how substances cross body barriers, this study focuses on pharmaceutical development with no connection to microplastic contamination or health effects.
Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies
This review of gut-on-a-chip systems for drug development highlights the key design components including chip fabrication materials, tissue engineering approaches, and biochemical cues, covering their applications for studying oral drug bioavailability and intestinal disease treatment.
Critical features of an in vitro intestinal absorption model to study the first key aspects underlying food allergen sensitization
This study identified critical design features for in vitro intestinal absorption models to study food allergen sensitization, providing a framework for screening novel protein sources — including insect proteins and other alternative foods — for allergic risk.
Digestion of microplastics with simulated gastrointestinal conditions mitigates uptake by intestinal epithelial cells: Quantified by imaging flow cytometry
Researchers studied how simulated digestion affects the uptake of microplastics by intestinal cells. They found that microplastics that had been through a simulated digestive process were taken up at significantly lower rates compared to pristine particles. The findings suggest that digestive conditions may reduce how many microplastics actually cross the intestinal barrier, which is important for understanding real-world human exposure.
How Digestive Processes Can Affect the Bioavailability of PCBs Associated with Microplastics: A Modeling Study Supported by Empirical Data
Researchers used a simulated human digestive model to study whether gut processes change how quickly chemicals like PCBs transfer on and off microplastic particles. They found that digestive enzymes and bile salts significantly accelerated the release of these chemicals from microplastics, suggesting that the human gut environment may increase exposure to plastic-associated pollutants. The study provides new evidence that microplastics could act as carriers that release harmful chemicals more readily during digestion.
An automatic flow-through system for exploration of the human bioaccessibility of endocrine disrupting compounds from microplastics
An automated flow-through system was developed to investigate the bioaccessibility of plastic-borne contaminants in the human gastrointestinal tract using physiologically relevant body fluids. The system measured leaching rates of plastic additives under fasted and fed state conditions, providing the first mechanistic data on how ingested microplastics release chemical contaminants in the human gut.
Relevance of gut microbiome research in food safety assessment
This review examined how the gut microbiome metabolizes non-nutritious dietary compounds, arguing that gut microbial processing of food contaminants and additives is an underappreciated dimension of food safety assessment.