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Cell-Based In Vitro Models: Emerging Technologies for Enhanced Drug Permeability Prediction
Summary
This paper is not about microplastics. It reviews cell-based laboratory models used to predict how well drugs are absorbed through biological barriers like the gut, lung, and skin. While drug permeation research is relevant to understanding how substances cross body barriers, this study focuses on pharmaceutical development with no connection to microplastic contamination or health effects.
Early drug development gets a boost with cell-based in vitro models for drug permeation. These cost-effective tools track absorption rates and mechanisms, using immortalized epithelial cells that mimic various barriers (gut, lung, skin, etc.). This review explores key models and the intriguing challenge of bridging the gap between in vitro and real-world human absorption. Refining these models holds the key to optimizing drug discovery and bringing promising candidates to fruition.
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