We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models
Summary
Researchers used in vitro digestion models and Caco-2 cells to assess how the fungicide tebuconazole moves through the gut after consuming table grapes, finding nearly complete bioaccessibility (98.5%) after full digestion and showing that the compound crosses intestinal cells via passive transport.
In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is the main factor affecting bioaccessibility. With an increase in time, the tebuconazole in grapes was almost completely dissolved, with bioaccessibility reaching 98.5%, whereas dietary fiber reduced bioaccessibility. Tebuconazole undergoes carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical application value for correctly evaluating the harmful level of pollutants in the matrix to human body.
Sign in to start a discussion.
More Papers Like This
Oral Exposure to Epoxiconazole Disturbed the Gut Micro-Environment and Metabolic Profiling in Male Mice
Researchers found that oral exposure to the fungicide epoxiconazole disrupted gut microbiota composition and metabolic profiling in male mice, altering intestinal barrier function and mucus secretion with implications for gut health.
Capturing and Quantifying Particle Transcytosis with Microphysiological Intestine‐on‐Chip Models
A microphysiological intestinal model was used to quantify how nano- and microparticles cross the gut epithelium by transcytosis, providing more realistic transport data than standard Caco-2 monolayer assays. The system revealed size-dependent transport efficiency with implications for both drug delivery optimization and health risk assessment of ingested particles.
Mathematical modeling of fluid dynamics in in vitro gut fermentation systems: A new tool to improve the interpretation of microbial metabolism
This study developed fluid dynamics models using ordinary differential equations to simulate how compounds move through in vitro gut fermentation systems, helping distinguish true microbial metabolism from physical dilution. The models were validated against two commonly used in vitro systems to improve interpretation of dietary compound fate studies.
Bioaccessibility of microplastic-associated heavy metals using an in vitro digestion model and its implications for human health risk assessment
Researchers evaluated the bioaccessibility of heavy metals associated with microplastics using an in vitro digestion model to assess human health risks. The study found significant adsorption of arsenic, chromium, cadmium, and lead onto polyvinyl chloride microplastics, with varying bioaccessibility across different digestive phases. The findings suggest that incorporating bioaccessibility data into risk assessments may provide more accurate estimates of health risks from ingesting microplastic-associated heavy metals.
Sub-Chronic Difenoconazole Exposure Induced Gut Microbiota Dysbiosis in Mice
Male mice exposed to the fungicide difenoconazole for 56 days at 30 and 100 mg/kg/day developed gut microbiota dysbiosis, with disrupted microbial community composition that may indicate risks to mammalian health from agricultural fungicide residues.