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61,005 resultsShowing papers similar to Aquatic toxicity of tire microplastics on marine and freshwater organisms: An in silico approach
ClearMitigating risk of tire wear particles in Daphnia pulex: In silico approaches
Researchers used computational molecular docking and simulation methods to evaluate the toxicity of tire wear particles on the aquatic organism Daphnia pulex. They screened 96 different tire rubber formulations and identified one with the lowest predicted ecological risk. The study suggests that optimizing tire additive combinations could help reduce the environmental toxicity of tire-derived microplastic pollution in aquatic ecosystems.
Exploring the Potential Hormonal Effects of Tire Polymers (TPs) on Different Species Based on a Theoretical Computational Approach
Researchers used molecular dynamics simulations to explore the potential hormonal toxicity of tire polymers across marine, freshwater, and soil environments, finding differences in how these prevalent microplastics interact with biological receptors in different species.
Toxicity evaluation of microplastics to aquatic organisms through molecular simulations and fractional factorial designs
Researchers used molecular docking, molecular dynamics, and fractional factorial design to evaluate the toxicity of ten common microplastic types to zebrafish, identifying polystyrene and polyvinylchloride as the most toxic based on binding interactions with key biological proteins.
Toxicity inhibition strategy of microplastics to aquatic organisms through molecular docking, molecular dynamics simulation and molecular modification
Researchers used molecular docking and dynamics simulations to study the combined toxic effects of microplastics and their chemical additives on zebrafish receptor proteins. They found that different microplastic-additive combinations produced widely varying toxicity levels, and identified hydrophobic forces, hydrogen bonding, and electrostatic interactions as the main drivers of protein binding. The study proposes a computational framework for screening lower-toxicity plasticizer formulations and designing more environmentally friendly plastic materials.
Cocktail effects of tire wear particles leachates on diverse biological models: A multilevel analysis
Tire wear particles, a major but underappreciated source of microplastic pollution, leached chemicals into seawater that inhibited algae growth, caused developmental problems in zebrafish embryos, and showed hormone-disrupting effects in cell tests. The study found that water-soluble organic compounds from tires -- not just heavy metals like zinc -- were the primary drivers of toxicity, underscoring the need for better regulation of tire additives.
Toxicity of micro and nano tire particles and leachate for model freshwater organisms
Researchers tested the toxicity of micro- and nano-sized tire particles and their chemical leachates on zebrafish embryos and water fleas, two commonly used model organisms. They found that nano-sized tire particles were more toxic than micro-sized ones, and that the chemical leachate alone also caused significant developmental harm to zebrafish. The study demonstrates that tire debris poses a meaningful environmental risk to freshwater organisms through both direct particle exposure and the release of harmful chemicals.
Behind conventional (micro)plastics: An ecotoxicological characterization of aqueous suspensions from End-of-Life Tire particles
Researchers studied the toxic effects of ground-up end-of-life tire particles on zebrafish larvae and found that finer tire powder was more harmful than coarser granules. The smaller particles released chemicals into the water that altered over 100 proteins involved in metabolic processes. The study suggests that recycled tire materials leach toxic substances that could pose risks to aquatic organisms.
Co-exposure of TMPs and antibiotics in zebrafish: The influence of additives on the risk of hepatotoxicity
Researchers investigated how tire microplastics combined with antibiotics cause liver damage in zebrafish, focusing specifically on the role of chemical additives in the tire particles. They found that different antibiotic-tire microplastic combinations produced varying levels of liver toxicity, with certain additive chemicals playing a key role. The study suggests that the additives leaching from tire microplastics may be an underappreciated contributor to their environmental toxicity.
Hepatotoxicity, developmental toxicity, and neurotoxicity risks associated with co-exposure of zebrafish to fluoroquinolone antibiotics and tire microplastics: An in silico study
Using computer modeling, this study found that tire microplastics combined with common antibiotics caused significantly more liver damage in zebrafish than brain or developmental harm. The two pollutants worked together to amplify toxicity, meaning the combination was worse than either one alone. This highlights how microplastics in waterways can interact with other contaminants to create greater health risks for aquatic life and potentially for humans who consume seafood.
In silico insights into microplastic additive toxicity: Risks of pulmonary fibrosis and endocrine disruption
Researchers used computational modeling to investigate how five common microplastic additives, including phthalates and flame retardants, interact with proteins involved in lung fibrosis and endocrine function. Molecular docking revealed that these additives bind strongly to fibrotic markers like TGF-beta and to hormone receptors, suggesting potential mechanisms for tissue damage and hormonal disruption. The study highlights the need for further investigation into the health risks posed by chemical additives leaching from microplastics.
Comparative Toxicity of Micro, Nano, and Leachate Fractions of Three Rubber Materials to Freshwater Species: Zebrafish and .
Researchers compared the toxicity of micro, nano, and leachate fractions of three rubber materials—including tire rubber—to freshwater organisms. Nano-fractions and leachates generally showed higher toxicity than larger rubber particles, with leached chemicals driving much of the observed biological harm.
Mechanistic insight into the adverse outcome of tire wear and road particle leachate exposure in zebrafish (Danio rerio) larvae
Researchers studied how chemicals that leach from tire wear particles affect developing zebrafish, a common lab organism. The tire particle chemicals damaged eye development and impaired swimming behavior, even at concentrations found in the real environment. Since tire wear is one of the largest sources of microplastic pollution, these findings raise concerns about the ecological impact of road runoff on aquatic life.
Ecotoxicology of micronized tire rubber: Past, present and future considerations
This review synthesizes what is known about the ecotoxicology of micronized tire rubber particles, which are increasingly identified as a significant fraction of environmental microplastics, examining their effects on aquatic and terrestrial organisms. The authors note that tire rubber contains a complex mixture of chemical additives that may drive toxicity beyond the physical effects of the particles themselves.
Size-dependent ecotoxicological impacts of tire wear particles on zebrafish physiology and gut microbiota: Implications for aquatic ecosystem health
Researchers found that tire wear particles, a major but often overlooked source of microplastic pollution, affect zebrafish health differently depending on particle size. Smaller particles caused more severe gut microbiome disruption, oxidative stress, and immune responses, suggesting that tire-derived microplastics in waterways may pose a greater health risk to aquatic life than previously recognized.
Tire wear particles in different water environments: occurrence, behavior, and biological effects—a review and perspectives
This review examines tire wear particles, a major but often overlooked source of microplastics in water environments. Tire particles release toxic chemicals as they break down in water and can harm aquatic organisms, but most research has focused only on the chemical leachate rather than the particles themselves. Since tire wear contributes a large share of total microplastic pollution, understanding its full impact on water ecosystems and the food chain is important for human health.
Recycled polyvinyl chloride microplastics: investigation of environmentally relevant concentrations on toxicity in adult zebrafish
Researchers investigated the toxicity of recycled PVC microplastics at environmentally relevant concentrations in adult zebrafish, finding that these particles release chemicals that cause measurable toxic effects in exposed organisms.
Environmentally relevant concentrations of tyre particles cause toxicity in estuarine invertebrates
Researchers tested the toxicity of tire particles at environmentally relevant concentrations on estuarine species, finding that current environmental levels are sufficient to cause harm. The study identified the most sensitive species and life stages and highlighted tire particles as a priority microplastic source for regulatory attention.
Exploring the Potential Mechanism of Polyethylene Terephthalate Associated Cardiotoxicity through Network Toxicology and Molecular Docking
Researchers used computational approaches including network toxicology, molecular docking, and molecular dynamics simulations to explore how polyethylene terephthalate microplastics may affect cardiovascular function. The study identified potential molecular pathways through which PET exposure could contribute to cardiotoxicity. The findings provide a theoretical framework for understanding how plastic contaminants might interact with heart-related biological targets.
Microplastics in freshwater food chains: Priority list based on identification of oxidative stress response characteristic
Using computer simulations, researchers modeled how microplastics cause oxidative stress across freshwater food chains, finding that lower-level organisms like algae experience more damage than fish at the top. The study also identified which types of plastics and chemical additives pose the greatest risk, providing a priority list to guide pollution management in freshwater environments.
Toxicological review of micro- and nano-plastics in aquatic environments: Risks to ecosystems, food web dynamics and human health.
This review synthesized evidence on the toxicological effects of micro- and nanoplastics in aquatic ecosystems, covering risks to individual organisms, disruptions to food web dynamics, and pathways through which plastic exposure poses risks to human health via seafood consumption.
Integrative network toxicology and molecular docking preliminarily explore the potential role of polystyrene microplastics in childhood obesity
Researchers used an integrative computational approach combining cross-species transcriptomics, network toxicology, and molecular docking to investigate potential links between polystyrene microplastic exposure and childhood obesity. They identified shared gene targets involved in lipid metabolism and insulin signaling pathways, with molecular docking confirming stable binding between microplastic compounds and key metabolic proteins. The findings provide a preliminary molecular hypothesis suggesting microplastics could disrupt metabolic processes relevant to obesity.
Molecular mechanisms of microplastic toxicity in coastal sediments of La Guajira Colombia and emerging ecological risks
Researchers conducted the first study of microplastic contamination in coastal sediments along La Guajira, Colombia, finding an average of about 102 particles per kilogram of sediment. The study used molecular docking to explore how common plastic polymers and their additives could interact with biological molecules, suggesting potential ecological risks from microplastic toxicity in these coastal environments.
An effect factor approach for quantifying the impact of plastic additives on aquatic biota in life cycle assessment
Researchers developed a preliminary effect factor approach to quantify the environmental impact of plastic additives on aquatic organisms within life cycle assessment frameworks, addressing a critical gap in how marine plastic chemical impacts are characterized.
Research Progress of Zebrafish Model in Aquatic Ecotoxicology
This review examines how zebrafish are used as model organisms to study the toxic effects of environmental pollutants in water, including microplastics. Zebrafish are ideal because they reproduce quickly, are inexpensive to maintain, and allow researchers to study effects at the genetic, cellular, and whole-organism level. The paper provides a reference guide for scientists choosing model animals for aquatic toxicology research.