We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Ischemic Stroke Induces Skeletal Muscle Damage and Alters Transcriptome Profile in Rats
ClearPolystyrene microplastics (PS-MPs) disturb skeleto-muscular energy metabolism and tissue architecture following sub-acute exposure: A dose-responsive study
Wistar rats given polystyrene microplastics in drinking water (0.5–50 mg/L) for 28 days showed dose-dependent disruption of skeletal muscle energy metabolism — including reduced ATP production and altered mitochondrial activity — along with histological changes in muscle tissue architecture.
A comprehensive analysis of the hub genes for oxidative stress in ischemic stroke
Integrating three ischemic stroke genomic datasets identified nine hub genes involved in oxidative stress responses including TLR1, MMP9, and TLR4, which were highly expressed in stroke samples and associated with neutrophil and macrophage infiltration, with machine learning models confirming their predictive value.
Exposome on skeletal muscle system: a mini-review
This mini-review examines how environmental exposures, including microplastics, heavy metals, and other pollutants, affect skeletal muscle biology. Evidence indicates that microplastics may delay muscle regeneration and promote fat cell formation through specific signaling pathways, suggesting that cumulative environmental exposures could have meaningful effects on muscle health across the lifespan.
Emerging roles of tRNA-derived small RNAs in injuries
This review systematically covers tRNA-derived small RNAs (tsRNAs) as stress-responsive noncoding RNAs and discusses their roles as biomarkers and therapeutic targets across organ injuries including lung, liver, cardiac, neuronal, and skeletal muscle injuries.
Effects of Acute Exposure to Polystyrene Nanoplastics on the Channel Catfish Larvae: Insights From Energy Metabolism and Transcriptomic Analysis
Researchers found that acute exposure to polystyrene nanoplastics disrupted energy metabolism in channel catfish larvae, with transcriptomic analysis revealing altered gene expression in pathways related to oxidative stress and metabolic processes.
Redox regulation in aging muscles: exercise as a key modulator to combat sarcopenia and frailty
Researchers reviewed evidence on how aerobic and resistance exercise modulates redox homeostasis in aging skeletal muscle, synthesizing findings from randomized controlled trials and meta-analyses to show that exercise reduces oxidative stress markers by 10–20%, enhances antioxidant enzyme activity by 15–30%, and improves muscle strength and frailty scores through pathways including Nrf2, AMPK, and PGC-1α activation.
Polystyrene microplastics-induced ROS overproduction disrupts the skeletal muscle regeneration by converting myoblasts into adipocytes
Researchers found that polystyrene microplastics impaired skeletal muscle repair in mice by triggering excess production of reactive oxygen species (ROS) inside muscle stem cells. This oxidative stress redirected muscle stem cells to become fat cells instead of new muscle fibers, resulting in increased fat deposits and reduced muscle fiber size. The study suggests that microplastic exposure could interfere with the body's natural ability to regenerate and maintain muscle tissue.
[Physiological and Ecological Response Characteristics and Transcriptomic Change Characteristics of Rice （Oryza sativa）Under Different Microplastic Stresses].
Researchers used transcriptomic analysis to characterize physiological and ecological response characteristics of an aquatic organism exposed to microplastic stress, identifying gene expression changes in pathways related to immune function, oxidative stress, and energy metabolism.
Repetitive Transcranial Magnetic Stimulation Improves Neuropathy and Oxidative Stress Levels in Rats with Experimental Cerebral Infarction through the Nrf2 Signaling Pathway
Repetitive transcranial magnetic stimulation treatment of rats with experimentally induced cerebral infarction reduced neurological deficits, lowered oxidative stress markers, and increased expression of the Nrf2 and HO-1 protective pathway proteins, suggesting that rTMS exerts neuroprotective effects after ischemia-reperfusion injury partly through antioxidant signaling.
Abstract DP222: Microplastic Exposure Exacerbates Post-Stroke Depression and Memory Impairment
Researchers compared long-term functional outcomes after stroke in mice with and without prior microplastic exposure. The study found that microplastic exposure worsened post-stroke depression and memory impairment, suggesting that accumulated microplastics in the body may exacerbate neurological recovery outcomes following cerebrovascular events.
Influence of Polystyrene Microplastics on Mitochondrial Oxidative Damage in Renal and Muscular Tissues of the Freshwater Fish
Researchers exposed freshwater fish to environmentally relevant concentrations of polystyrene microplastics for up to 15 days and examined mitochondrial damage in kidney and muscle tissues. The exposure disrupted antioxidant defenses, increased oxidative stress, and altered metabolic enzyme activities in both tissue types. Histological examination revealed significant tissue damage including necrosis and degeneration, suggesting that microplastics can cause organ-level toxicity in fish through mitochondrial oxidative stress.
Role of TRPC6 in apoptosis of skeletal muscle ischemia/reperfusion injury
This study used TRPC6 knockout mice and hypoxia/reoxygenation cell models to show that TRPC6 is a key ion channel in skeletal muscle ischemia-reperfusion injury, with its deletion reducing calcium overload, decreasing apoptosis, and partially restoring exercise capacity.
Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes
Researchers exposed mouse spermatocytes to polystyrene nanoplastics and observed membrane disruption, mitochondrial damage, increased oxidative stress, and DNA damage within 24 hours. Transcriptomic analysis revealed 134 genes with altered expression, many linked to critical reproductive processes like sperm development and mitochondrial organization. The study suggests that nanoplastic exposure may interfere with male reproductive health at the cellular and genetic level.
Transcriptome Analysis Revealed the Early Heat Stress Response in the Brain of Chinese Tongue Sole (Cynoglossus semilaevis)
Researchers used transcriptome analysis to study how the brains of Chinese tongue sole fish respond to short-term heat stress. They identified distinct gene expression patterns in male and female fish, with key pathways related to cortisol production, immune signaling, and stress-response genes like heat shock proteins. The study provides new insights into the sex-specific brain mechanisms fish use to cope with temperature changes.
The mouse model of induced sperm DNA damage caused by polystyrene microplastics exhibited distinct transcriptomic and proteomic features
Researchers established a mouse model of polystyrene microplastic-induced sperm DNA damage by administering 1 mg/kg/day for 60 days, which significantly elevated the sperm DNA fragmentation index, and characterized the transcriptomic and proteomic profiles associated with this reproductive toxicity.
Mitochondrial Metabolism Characterization of Four Different Fish Cell Lines
Researchers characterized the mitochondrial metabolism and stress responses of four fish cell lines derived from different species and tissues, providing baseline data to support their use as in vitro models for evaluating the toxicity of environmental pollutants.
Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene
Researchers exposed larval tilapia to polystyrene nanoplastics and then analyzed changes in gene expression and metabolic profiles after a recovery period. They found that nanoplastic exposure disrupted immune-related pathways, energy metabolism, and lipid processing in the fish, with some effects persisting even after exposure ended. The study suggests that nanoplastics can cause lasting metabolic and immune disruptions in freshwater fish.
Maternal high-salt intake induces sex-specific liver injury in offspring: integrative transcriptomic and therapeutic investigation
Researchers found that maternal high-salt intake in rats produced sex-specific liver injury in offspring at the transcriptomic and structural level, with males showing greater susceptibility. The study highlights that developmental programming from maternal diet can predispose offspring to liver disease and suggests potential pharmacological interventions.
Identification of the Hub Genes Linked to Lead (IV)-Induced Spleen Toxicity Using the Rat Model
This paper is not about microplastics — it investigates gene expression pathways underlying lead-induced toxicity in the spleen using rat models, with no connection to plastic pollution.
Effects of the Myokine Irisin on Stromal Cells from Swine Adipose Tissue
Researchers investigated the effects of the exercise-induced hormone irisin on adipose tissue stromal cells from pigs, finding that it influences cell behavior and metabolic activity, with potential implications for understanding how physical activity regulates fat tissue and reproductive function.
Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress
This study examined how acute heat stress affects the physiology of the oriental river prawn, finding significant changes in gene expression and biochemistry that provide insight into how this commercially important species responds to warming water temperatures.
Abstract TMP110: Impact of Microplastics and Nanoplastics on Ischemic Stroke in Mice
Researchers investigated the effect of polyethylene and polystyrene micro/nanoplastics on ischemic stroke outcomes in mice using a transient middle cerebral artery occlusion model. Daily MNP pretreatment before stroke induction was assessed for effects on infarct volume and neurological outcomes, exploring the emerging hypothesis that MNPs may be a cerebrovascular risk factor.
Polystyrene nanoplastics trigger mitochondrial and metabolic reprogramming in cardiomyocytes: Evidence from integrated transcriptomic and metabolomic analysis
Scientists found that tiny plastic particles called nanoplastics can damage heart cells by disrupting their powerhouses (mitochondria) and reducing their ability to produce energy. When researchers exposed human heart cells and mice to these nanoplastics, they observed weakened heart function and signs of early heart damage. This research suggests that the growing amount of microscopic plastic pollution in our environment could pose previously unknown risks to heart health.
Toxicological effects of microplastics in renal ischemia–reperfusion injury
Researchers studied how microplastic exposure affects kidney injury and recovery in a mouse model of reduced blood flow to the kidneys. They found that microplastics worsened kidney damage by triggering inflammatory responses and disrupting cellular repair processes. The study suggests that microplastic accumulation in the body may increase vulnerability to kidney complications.