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Emerging roles of tRNA-derived small RNAs in injuries
Summary
This review systematically covers tRNA-derived small RNAs (tsRNAs) as stress-responsive noncoding RNAs and discusses their roles as biomarkers and therapeutic targets across organ injuries including lung, liver, cardiac, neuronal, and skeletal muscle injuries.
tRNA-derived small RNAs (tsRNAs) are a novel class of small noncoding RNAs, precisely cleaved from tRNA, functioning as regulatory molecules. The topic of tsRNAs in injuries has not been extensively discussed, and studies on tsRNAs are entering a new era. Here, we provide a fresh perspective on this topic. We systematically reviewed the classification, generation, and biological functions of tsRNAs in response to stress, as well as their potential as biomarkers and therapeutic targets in various injuries, including lung injury, liver injury, renal injury, cardiac injury, neuronal injury, vascular injury, skeletal muscle injury, and skin injury. We also provided a fresh perspective on the association between stress-induced tsRNAs and organ injury from a clinical perspective.
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