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Maternal high-salt intake induces sex-specific liver injury in offspring: integrative transcriptomic and therapeutic investigation
Summary
Researchers found that maternal high-salt intake in rats produced sex-specific liver injury in offspring at the transcriptomic and structural level, with males showing greater susceptibility. The study highlights that developmental programming from maternal diet can predispose offspring to liver disease and suggests potential pharmacological interventions.
Maternal high-salt intake induces sex-specific structural and molecular liver injury in offspring, highlighting the developmental origins of liver disease. These findings emphasize the importance of maternal nutrition in shaping offspring hepatic health and suggest potential pharmacological strategies to counteract early-life dietary insults.
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