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20 resultsShowing papers similar to The simultaneous administration of microplastics and cadmium alters rat testicular activity and changes the expression of PTMA, DAAM1 and PREP
ClearCombined effect of polystyrene microplastics and cadmium on rat blood-testis barrier integrity and sperm quality
Researchers exposed male rats to polystyrene microplastics and cadmium, both separately and together, and found that both substances damaged testicular tissue, disrupted the blood-testis barrier, and reduced sperm quality. Notably, the combined exposure was less severe than cadmium alone, likely because microplastics absorbed some cadmium in the gut and reduced its bioavailability. The study also found for the first time that microplastics trigger autophagy in reproductive cells as a protective response.
Synergistic effect of PS-MPs and Cd on male reproductive toxicity: Ferroptosis via Keap1-Nrf2 pathway
A mouse study found that microplastics and the heavy metal cadmium work together to cause more severe damage to male reproductive organs than either pollutant alone. The combination triggered a form of cell death called ferroptosis by disrupting a key protective pathway in the body. This is the first study to show this synergistic reproductive harm, suggesting that microplastics can make other environmental toxins more dangerous.
The single and combined effects of decabromodiphenyl ethane and mixed microplastics on male mice reproductive toxicity
Researchers investigated the combined reproductive toxicity of mixed microplastics and the flame retardant DBDPE in male mice over seven weeks. The study found that DBDPE alone decreased sex hormone levels and sperm count, and when combined with microplastics, the effects on testicular damage, sperm malformation, and oxidative stress were compounded, suggesting that microplastics may amplify the toxicity of co-occurring chemical contaminants.
Maternal Exposureto Combined Cadmium and PolystyreneNanoplastics Induces Offspring Testicular Dysplasia via MitochondrialReactive Oxygen Species Overactivating the Peroxisome Proliferator-ActivatedReceptor α‑Mediated Autophagy Signaling Pathway
Maternal exposure to combined polystyrene nanoplastics and cadmium during pregnancy caused testicular dysplasia in offspring via mitochondrial reactive oxygen species overactivating the PPARα-mediated autophagy pathway, with combined exposure more harmful than either alone.
Nanoplastic PS and cadmium co-exposure accelerates ferroptosis mediated by HIF-1α-related signaling in spermatogonium
Researchers exposed mouse sperm precursor cells to nanoplastics combined with cadmium and found that co-exposure caused significantly more cell damage than either contaminant alone. The combined treatment triggered a form of cell death called ferroptosis through a specific signaling pathway involving the gene HIF-1a. The study suggests that nanoplastics may worsen the reproductive toxicity of heavy metals commonly found alongside plastic pollution in the environment.
Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis
Researchers found that polystyrene nanoplastics combined with bacterial toxins (LPS) caused worse damage to mouse testicles than either substance alone, reducing sperm count, lowering testosterone levels, and increasing inflammation. Since microplastics in the environment can carry bacteria and their toxins, this combination exposure is realistic. The findings suggest that nanoplastic pollution could amplify the reproductive harm caused by bacterial infections in males.
Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish
Researchers exposed adult zebrafish to polyethylene microplastics and cadmium, both individually and in combination, for 21 days. They found that microplastics and cadmium together produced additive toxic effects, increasing cadmium accumulation in fish tissues, altering behavior, and causing more severe organ damage. The study suggests that microplastics in contaminated waterways may worsen the harmful effects of heavy metals on aquatic life.
Dose-Dependent Effect of Polystyrene Microplastics on the Testicular Tissues of the Male Sprague Dawley Rats
Male rats exposed to increasing doses of polystyrene microplastics showed dose-dependent testicular damage including disrupted spermatogenesis and altered hormone levels, suggesting potential reproductive toxicity from microplastic accumulation.
Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics combined with cadmium for three weeks and found that the presence of microplastics significantly increased cadmium accumulation in the liver, gut, and gills. The combined exposure caused greater oxidative damage, tissue inflammation, and disruption of protective gene activity than either pollutant alone. The study demonstrates that microplastics can enhance the toxicity of heavy metals in fish by acting as carriers that increase the body's uptake of harmful substances.
Effects of Co-exposure to Microplastics and Cadmium on the Binding of Protamine-like Proteins to DNA in Mytilus Galloprovincialis
Researchers found that co-exposure of Mytilus galloprovincialis mussels to microplastics and cadmium disrupted the binding of protamine-like proteins to sperm DNA, potentially compromising chromatin integrity and fertilization success in an already-stressed marine environment.
Co-exposure of cadmium and polystyrene nanoplastics: Induction pyroptosis and autophagy in mice testis
Researchers investigated the combined effects of cadmium and polystyrene nanoplastics on mouse testicular tissue. The study found that co-exposure produced more severe testicular damage than either substance alone, driven by the interplay between pyroptosis (inflammatory cell death) and autophagy. Inhibiting one of these cellular processes affected the other, suggesting they are closely interconnected in the toxicity response to nanoplastic and heavy metal co-exposure.
Combined exposure to titanium nanoparticles and nanoplastics damages the male reproductive system and sperm activity
This study assessed the effects of combined TiO2 nanoparticles and polystyrene nanoplastics on male reproductive function in animal models, finding that co-exposure caused greater damage to sperm motility, testicular structure, and hormone levels than either material alone. The results raise concerns about combined environmental exposure to two common industrial nanomaterials.
Maternal Exposure to Combined Cadmium and Polystyrene Nanoplastics Induces Offspring Testicular Dysplasia via Mitochondrial Reactive Oxygen Species Overactivating the Peroxisome Proliferator-Activated Receptor α-Mediated Autophagy Signaling Pathway
Researchers investigated the combined effects of maternal exposure to polystyrene nanoplastics and cadmium on offspring in a mouse model. The study found that co-exposure caused testicular developmental abnormalities in offspring through mitochondrial oxidative stress and disrupted autophagy signaling, suggesting that nanoplastics may amplify the reproductive toxicity of co-occurring environmental contaminants.
Microplastics and male reproductive system: A comprehensive review based on cellular and molecular effects
This comprehensive review examines how microplastics affect the male reproductive system at cellular and molecular levels, drawing on studies from multiple scientific databases. Researchers found that microplastics can damage testicular structure and function, impair spermatogenesis, and disrupt sperm parameters through mechanisms including oxidative stress, inflammation, and activation of cell death pathways. The review highlights that microplastics reduce ATP production and trigger signaling cascades that may contribute to male fertility problems.
Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
Researchers exposed mice to microplastics and cadmium for three months and found that microplastics significantly worsened cadmium-induced kidney injury. The combined exposure enhanced oxidative stress, autophagy, cell death, and tissue scarring in the kidneys beyond what cadmium alone caused. The study suggests that microplastics may act as amplifiers of heavy metal toxicity in organ systems.
Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
Researchers studied the combined toxic effects of polystyrene microplastics and cadmium at different concentrations in zebrafish over a 10-day exposure period. The study found that microplastics could either amplify or reduce cadmium toxicity depending on the metal concentration, affecting survival, growth, and antioxidant responses in complex ways.
Co-exposure to polystyrene microplastics and microcystin-LR aggravated male reproductive toxicity in mice
Researchers found that exposing mice to a combination of polystyrene microplastics and microcystin-LR, a toxin produced by algae, caused more severe damage to male reproductive organs than either pollutant alone. The microplastics increased the amount of the toxin that accumulated in testicular tissue. The study suggests that the interaction between microplastics and other environmental contaminants may amplify reproductive health risks.
Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats
Researchers studied the chronic toxic effects of polystyrene microplastics on the reproductive system of male rats over 90 days. The study found significant reductions in sperm volume, motility, epididymal count, and serum testosterone levels, along with disrupted testicular architecture and decreased antioxidant capacity. The findings suggest that chronic microplastic exposure may adversely affect male reproductive parameters in mammals.
PS-MPs or their co-exposure with cadmium impair male reproductive function through the miR-199a-5p/HIF-1α-mediated ferroptosis pathway
Researchers found that polystyrene microplastics, especially when combined with cadmium, caused significant reproductive damage in male mice through a cell death pathway called ferroptosis. Smaller microplastic particles were more toxic than larger ones, and the combination of microplastics with cadmium amplified the harm beyond what either caused alone. The study identifies a specific molecular mechanism by which microplastics and heavy metals together may threaten male reproductive health.
Evaluation of single and combined effects of cadmium and micro-plastic particles on biochemical and immunological parameters of common carp (Cyprinus carpio)
Researchers investigated the individual and combined toxicity of cadmium and polystyrene microplastics on common carp over 30 days. They found that co-exposure to both pollutants produced more severe effects on liver enzymes, immune function, and biochemical markers than either pollutant alone. The study suggests that microplastics can enhance the toxicity of heavy metals in aquatic organisms, raising concerns about the combined impact of these co-occurring contaminants.