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Human Health Effects
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Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis
International Journal of Molecular Sciences2022
60 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 55
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Tao Wang,
Tao Wang,
Tao Wang,
Jian Sun,
Tao Wang,
Hui Zou
Hui Zou
Hui Zou
Tao Wang,
Jian Sun,
Jian Sun,
Tao Wang,
Tao Wang,
Tao Wang,
Huayi Qu,
Huayi Qu,
Huayi Qu,
Huayi Qu,
Yan Chen,
Tao Wang,
Huayi Qu,
Jian Sun,
Tao Wang,
Tao Wang,
Tao Wang,
Jian Sun,
Huayi Qu,
Jian Sun,
Tao Wang,
Tao Wang,
Hui Zou
Tao Wang,
Tao Wang,
Jian Sun,
Hui Zou
Hui Zou
Tao Wang,
Hui Zou
Yonggang Ma,
Tao Wang,
Tao Wang,
Tao Wang,
Yonggang Ma,
Tao Wang,
Yan Yuan,
Zongping Liu,
Yonggang Ma,
Tao Wang,
Yonggang Ma,
Hui Zou
Yonggang Ma,
Tao Wang,
Yonggang Ma,
Yan Yuan,
Yan Yuan,
Zongping Liu,
Yonggang Ma,
Yonggang Ma,
Yonggang Ma,
Yonggang Ma,
Yonggang Ma,
Zongping Liu,
Yan Yuan,
Yonggang Ma,
Hui Zou
Yan Yuan,
Yonggang Ma,
Yan Yuan,
Yan Yuan,
Yan Yuan,
Yan Yuan,
Yonggang Ma,
Yonggang Ma,
Yan Yuan,
Yonggang Ma,
Yonggang Ma,
Zongping Liu,
Jianchun Bian,
Yan Yuan,
Jianchun Bian,
Jianchun Bian,
Jianchun Bian,
Yonggang Ma,
Jianchun Bian,
Jianchun Bian,
Jianchun Bian,
Hui Zou
Jianchun Bian,
Zongping Liu,
Zongping Liu,
Yonggang Ma,
Tao Wang,
Yan Yuan,
Zongping Liu,
Jianchun Bian,
Hui Zou
Hui Zou
Zongping Liu,
Zongping Liu,
Jianchun Bian,
Hui Zou
Hui Zou
Zongping Liu,
Zongping Liu,
Zongping Liu,
Jianchun Bian,
Hui Zou
Hui Zou
Summary
Researchers exposed mice to microplastics and cadmium for three months and found that microplastics significantly worsened cadmium-induced kidney injury. The combined exposure enhanced oxidative stress, autophagy, cell death, and tissue scarring in the kidneys beyond what cadmium alone caused. The study suggests that microplastics may act as amplifiers of heavy metal toxicity in organ systems.
Cadmium (Cd) is a potential pathogenic factor in the urinary system that is associated with various kidney diseases. Microplastics (MPs), comprising of plastic particles less than 5 mm in diameter, are a major carrier of contaminants. We applied 10 mg/L particle 5 μm MPs and 50 mg/L CdCl2 in water for three months in vivo assay to assess the damaging effects of MPs and Cd exposure on the kidney. In vivo tests showed that MPs exacerbated Cd-induced kidney injury. In addition, the involvement of oxidative stress, autophagy, apoptosis, and fibrosis in the damaging effects of MPs and Cd on mouse kidneys were investigated. The results showed that MPs aggravated Cd-induced kidney injury by enhancing oxidative stress, autophagy, apoptosis, and fibrosis. These findings provide new insights into the toxic effects of MPs on the mouse kidney.