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20 resultsShowing papers similar to Erchen Decoction Alleviates High-Fat Diet + AOM/DSS-Induced CRC by Ameliorating Cholesterol-Bile Acid Metabolism Disorder through Regulating FXR and the Gut Microbiota
ClearJianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota
Researchers found that a traditional Chinese herbal medicine formula called Jianwei Xiaoshi oral liquid improved functional digestive problems in young rats fed a high-calorie diet by regulating eight key proteins involved in pancreatic digestion and restoring healthy gut bacteria balance. The findings suggest potential therapeutic benefits of this herbal remedy for diet-induced digestive disorders in children.
Ameliorative effects of mulberry fruit anthocyanin extract on gut microbiota and liver metabolites in high-fat and high-cholesterol diet-fed ApoE−/− mice
Researchers investigated mulberry anthocyanin extract in high-fat, high-cholesterol diet-fed mice and found it reduced LDL cholesterol and inflammatory markers while favorably shifting gut microbial composition and modulating liver metabolites including glutamine and ATP, suggesting a mechanism linking gut microbiota to atherosclerosis risk reduction.
Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis
Researchers examined how mulberry leaves and black sesame alleviate slow transit constipation in a mouse model, measuring gut motility, microbiota composition, and intestinal gene expression. Both dietary interventions increased beneficial bacteria, enhanced gut peristalsis, and upregulated genes associated with intestinal motility, supporting their traditional use for digestive health.
Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice
Researchers found that subchronic exposure to the cyanotoxin microcystin-LR aggravated colorectal inflammation and barrier disruption in obese mice fed a high-fat diet, operating through the Raf/ERK signaling pathway to worsen pre-existing gut damage.
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
This review examines the phytochemical constituents of Sanyeqing (a traditional medicinal plant) and their therapeutic potential for inflammatory bowel disease and colorectal cancer, identifying anti-inflammatory and anti-tumor mechanisms that could complement conventional treatments.
Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review)
This review covers chemoprevention strategies for precancerous lesions in patients at elevated cancer risk, evaluating evidence for pharmacological and dietary interventions including natural compounds that modulate carcinogenic pathways. The authors assess clinical trial evidence and identify specific compounds with strong evidence for reducing progression from precancerous to malignant lesions.
Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota
Researchers investigated the protective effects of Laowuzeng Jiuzao polysaccharides on ethanol-induced alcoholic fatty liver in zebrafish larvae, finding that the polysaccharides reduced hepatic damage and regulated intestinal microbiota composition, suggesting therapeutic potential for alcohol-related liver disease.
An Ilex latifolia‐containing compound tea regulates glucose–lipid metabolism and modulates gut microbiota in high‐fat diet‐fed mice
This study investigated how a compound tea containing Kuding Tea, green tea, and Luohan fruit affects glucose and lipid metabolism in mice fed a high-fat diet. Researchers found that the tea blend helped regulate metabolic parameters and modulated gut microbiota composition, suggesting potential benefits for managing metabolic health.
Tanshinone IIA May Inhibit Gastric Cancer via Affecting the Intestinal Microbiome
Researchers investigated whether tanshinone IIA, a compound derived from Salvia miltiorrhiza, inhibits gastric cancer tumor growth through modulation of the intestinal microbiome and regulation of NF-kB signaling. The study found that tanshinone IIA altered the gut microbial composition and suppressed NF-kB pathway activity, suggesting a microbiome-mediated mechanism underlying its anti-tumor effects.
The Interaction between Oxidative Stress Biomarkers and Gut Microbiota in the Antioxidant Effects of Extracts from Sonchus brachyotus DC. in Oxazolone-Induced Intestinal Oxidative Stress in Adult Zebrafish
Researchers found that extracts from Sonchus brachyotus DC. alleviated oxazolone-induced intestinal oxidative stress in zebrafish by modulating antioxidant enzyme activity and reshaping gut microbiota composition.
The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.
Gut microbiota remodeling drived by dietary millet protein prevents the metabolic syndrome
Researchers found that millet bran protein extract prevented metabolic syndrome in high-fat diet mice by remodeling gut microbiota and reducing obesity, chronic inflammation, and insulin resistance. The protective effects were linked to specific gut microbial metabolites influenced by dietary millet protein.
Role of dietary nutrients and metabolism in colorectal cancer.
This review examines how dietary nutrients including glucose, amino acids, lipids, vitamins, and prebiotics may influence colorectal cancer risk and progression. The study discusses metabolic interactions between tumor cells, the tumor microenvironment, and gut microbiota, suggesting that nutritional factors play a meaningful role in shaping these complex biological processes.
CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE
Researchers assessed the chemopreventive potential of an alcoholic extract of a polyherbal preparation including Phyllanthus amarus in a precancerous lesion model, measuring effects on biomarkers of oxidative stress and inflammation. The herbal extract reduced key biomarkers compared to untreated controls, supporting further investigation of plant-derived compounds as adjuncts in cancer chemoprevention.
Resveratrol attenuated high intensity exercise training-induced inflammation and ferroptosis via Nrf2/FTH1/GPX4 pathway in intestine of mice
Researchers found that resveratrol attenuated inflammation and ferroptosis caused by high-intensity exercise training in the intestines of mice. The protective effect was mediated through activation of the Nrf2/FTH1/GPX4 pathway in colon tissue, suggesting potential applications for preventing exercise-induced gut damage.
Electroacupuncture treatment ameliorates metabolic disorders in obese ZDF rats by regulating liver energy metabolism and gut microbiota
Researchers found that electroacupuncture treatment improved blood sugar and fat metabolism in obese rats by reshaping their gut bacteria and altering liver metabolic pathways. The treatment boosted beneficial gut bacteria, reduced harmful ones, and influenced key processes like fat production and amino acid metabolism in the liver. The study suggests a strong connection between the gut microbiome and liver function in metabolic health.
Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis
Researchers found that protocatechuic acid, a naturally occurring compound found in many fruits and vegetables, helped alleviate ulcerative colitis in mice by restoring healthy gut bacteria and reducing a type of cell death called ferroptosis. The treatment improved intestinal barrier integrity and reduced inflammation. This is relevant to microplastics research because gut barrier damage is a key concern with microplastic ingestion.
Seaweed polysaccharide relieves hexavalent chromium-induced gut microbial homeostasis
Researchers found that seaweed polysaccharides can restore gut microbial balance disrupted by hexavalent chromium exposure in mice, reducing pathogenic bacteria and increasing beneficial species, suggesting a potential dietary intervention for heavy metal-induced intestinal damage.
Active compounds of licorice ameliorate microplastics-induced intestinal damage by targeting FADD
Researchers tested whether active compounds from licorice root could protect intestinal cells from damage caused by microplastic exposure in mice, finding that licorice compounds reduced inflammation and oxidative stress in the gut and partially restored intestinal barrier integrity.
Lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism
Researchers showed that Lactobacillus plantarum A3, a probiotic strain isolated from horses, reduced symptoms of ulcerative colitis in mice whose gut microbiomes had been disrupted by antibiotics. The probiotic restored beneficial bacteria like Akkermansia, reduced gut inflammation, and increased levels of natural anti-inflammatory compounds in the body.