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61,005 resultsShowing papers similar to Microbial colonization of microplastics in wastewater accelerates the aging process associated with oxidative stress and the insulin/IGF1 signaling pathway
ClearSeawater Accelerated the Aging of Polystyrene and Enhanced Its Toxic Effects on Caenorhabditis elegans
Researchers simulated the aging of polystyrene microplastics in seawater and found that the marine environment accelerated surface erosion, releasing smaller aged particles. When tested on the nematode C. elegans, the aged polystyrene caused greater reductions in movement, vitality, and reproduction compared to virgin particles, driven by increased oxidative stress. The findings suggest that microplastics become more toxic as they weather in ocean conditions.
Sorption processes of wastewater contaminants on virgin and aged polystyrene microplastics: physicochemical changes and cellular toxicity assessment
Researchers exposed 1 µm polystyrene microplastics (virgin and thermo-oxidation aged) to wastewater and then assessed their adsorption behaviour and cytotoxicity. Aged MPs adsorbed more contaminants from wastewater and showed greater cytotoxicity to human cells than virgin MPs, demonstrating that environmental ageing amplifies the health risks of microplastics.
Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells
Researchers found that microplastic exposure accelerates aging in fat tissue by triggering cellular senescence (a state where cells stop dividing and release inflammatory signals) in both mice and cell cultures. The microplastics accumulated in fat tissue, increased markers of aging and inflammation, and disrupted the normal development of new fat cells. These findings suggest that chronic microplastic exposure could contribute to age-related metabolic problems and obesity-related diseases in humans.
Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway
Researchers found that photoaged polystyrene microplastics accelerated aging in the nematode C. elegans at environmentally relevant concentrations far more than fresh particles. The aged plastics generated more persistent free radicals and accumulated more readily in the organisms, triggering ferroptosis, a form of iron-dependent cell death, and disrupting insulin signaling pathways. The study suggests that environmental weathering makes microplastics substantially more harmful to biological aging processes.
Polystyrene Accelerates Aging Related-Gut Microbiome Dysbiosis and -Metabolites in Old-Aged Mouse
This mouse study investigated whether polystyrene microplastic exposure accelerates aging-related gut microbiome dysbiosis, using 16S rDNA sequencing and metabolomics. Polystyrene exposure disrupted the gut microbiota composition and altered fecal metabolite profiles in ways consistent with accelerated aging phenotypes.
СЛЕД МИКРОПЛАСТИКА В ГЕРОНТОЛОГИИ: МЕТААНАЛИЗ ЕГО РОЛИ В МОДУЛЯЦИИ ДОЛГОЛЕТИЯ
This meta-analysis of 33 studies examined how microplastics may affect aging and longevity. It found that microplastic exposure was linked to increased oxidative stress, inflammation, and cellular aging markers, suggesting that long-term microplastic accumulation in the body could potentially accelerate the aging process.
Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence
This review summarizes research showing that micro- and nanoplastics trigger oxidative stress, inflammation, and premature cell aging across many experimental models. These are the same biological processes linked to heart disease, brain disorders, and other age-related conditions. Particularly concerning, studies in animals show that plastic-related damage can be passed from parents to offspring, suggesting potential long-term generational health effects.
Micro- and Nanoplastics Exposure Across the Lifespan: One Health Implications for Aging and Longevity
Researchers reviewed evidence on micro- and nanoplastic exposure across the human lifespan through a One Health lens, finding that MNPs trigger oxidative stress, inflammation, mitochondrial dysfunction, and cellular senescence—mechanisms central to aging—and that older adults face compounded risk from lifetime accumulation and diminished physiological resilience, though direct epidemiological data in this population remain sparse.
Hepatotoxic effects of environmentally relevant concentrations of polystyrene microplastics on senescent Zebrafish (Danio rerio): Patterns of stress response and metabolomic alterations
Researchers exposed aging zebrafish to environmentally realistic levels of polystyrene microplastics and found significant liver damage, including disrupted stress responses and altered metabolism. This study is notable because it focused on older organisms, suggesting that elderly populations may be more vulnerable to the toxic effects of microplastic exposure.
Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging
Researchers found that polystyrene microplastic exposure worsened intestinal barrier dysfunction in mice on high-fat diets, with the combination of obesity and microplastic exposure producing greater gut permeability and inflammation than either factor alone, suggesting compounding risks in metabolically vulnerable individuals.
Polystyrene microplastics facilitate renal fibrosis through accelerating tubular epithelial cell senescence
Mice exposed to polystyrene microplastics at doses relevant to human exposure developed kidney inflammation and scarring (fibrosis) within 28 days. The microplastics caused kidney tube cells to age prematurely, triggering a chain reaction that activated scar-forming cells through a specific signaling pathway. This study provides evidence that microplastic exposure could contribute to chronic kidney damage in people.
Wastewater preinteraction accelerates the photoaging of disposable box-derived polystyrene microplastics in water
Researchers found that pre-exposure of polystyrene microplastics to real wastewater significantly accelerated their subsequent photoaging under UV light — doubling oxidation rates — with fulvic acid identified as the primary wastewater constituent driving this enhancement.
Biochemical and physiological effects of multigenerational exposure to spheric polystyrene microplastics in Caenorhabditis elegans
Researchers found that multigenerational exposure of C. elegans to polystyrene microplastics at low concentrations triggered oxidative stress, increased detoxification enzyme activity, and caused accumulating physiological effects across five consecutive generations.
Microplastics Exposure Causes the Growth Hormone Resistance on the Stem Cell
Researchers investigated how polystyrene microplastics affect the ability of human stem cells to respond to growth hormone. They found that microplastics entered the cells and increased harmful reactive oxygen species, which led to cellular aging and significantly reduced growth hormone signaling pathways. The study suggests that microplastic exposure may interfere with important cellular growth and repair processes by making cells less responsive to growth hormone.
Aged polystyrene microplastics exposure affects apoptosis via inducing mitochondrial dysfunction and oxidative stress in early life of zebrafish
Zebrafish embryos exposed to UV-aged polystyrene microplastics at environmental concentrations showed more severe developmental problems than those exposed to fresh microplastics. The aged particles caused greater oxidative stress and mitochondrial damage, triggering increased cell death during early development -- suggesting that weathered microplastics in the real environment may be more harmful than the pristine particles typically used in lab studies.
Dose-Dependent Responses of Escherichia coli and Acinetobacter sp. to Micron-Sized Polystyrene Microplastics
Researchers exposed E. coli and Acinetobacter sp. to 1,040 nm polystyrene microplastics across a range of concentrations and assessed growth, oxidative stress, membrane integrity, and biofilm formation. Both species showed concentration-dependent decreases in growth and cell viability, increased oxidative stress markers, impaired membrane integrity, and enhanced biofilm formation, demonstrating microplastic toxicity to environmental and human-associated bacteria.
Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathway
Researchers found that polystyrene microplastics can be taken up by osteocytes, the most abundant cells in bone tissue, and cause them to undergo premature aging through a process called senescence. The microplastics triggered oxidative stress and activated a specific inflammatory signaling pathway involving cyclooxygenase-2. The study suggests that microplastic exposure could potentially impair bone health by disrupting the normal function of the cells responsible for maintaining bone tissue.
Nanoplastics: An emerging environmental concern in age-related diseases
This review examines the growing body of evidence linking nanoplastics to aging and age-related conditions. Researchers found that nanoplastics can disrupt key molecular pathways involved in inflammation, oxidative stress, and cellular damage that are central to the aging process. The study suggests that chronic nanoplastic exposure may accelerate biological aging, raising concerns about long-term health effects as environmental plastic pollution continues to increase.
Understanding microplastic aging driven by photosensitization of algal extracellular polymeric substances
Researchers found that substances released by algae significantly speed up the breakdown of polystyrene microplastics under sunlight. The algal compounds generate reactive molecules that attack the plastic surface, creating smaller fragments and releasing dissolved organic matter. The findings are particularly relevant for understanding how microplastics degrade in waterways affected by algal blooms.
Aging process does not necessarily enhance the toxicity of polystyrene microplastics to Microcystis aeruginosa
Researchers compared the properties and toxicity of pristine versus aged polystyrene microplastics of different sizes on the freshwater cyanobacterium Microcystis aeruginosa. The study found that the aging process does not necessarily increase microplastic toxicity, as aging induced changes in surface properties, functional groups, and zeta potential that could either enhance or reduce toxic effects depending on particle size.
Microplastics and Skin Aging: Disruption of Barrier Function and Induction of Fibroblast Senescence
Researchers investigated how polystyrene microplastics affect skin health using lab-grown skin cells and gene expression analysis. They found that microplastic exposure disrupted the skin's protective barrier by inhibiting normal skin cell development and accelerated aging in the deeper skin layer by triggering cellular senescence. The study suggests that microplastics may contribute to premature skin aging and weakened skin barrier function, adding to the growing understanding of how these particles affect human health.
Potential toxicity of nanopolystyrene on lifespan and aging process of nematode Caenorhabditis elegans
Researchers chronically exposed C. elegans to nanopolystyrene across their aging lifespan and found that high concentrations shortened lifespan while lower concentrations still impaired locomotion and elevated intestinal reactive oxygen species in older animals, with nanoplastic exposure progressively suppressing immune genes, antioxidant defenses, and mitochondrial stress responses as worms aged.
Polystyrene nanoplastics promote muscle cell senescence through microtubule hyper-stabilization-mediated mitophagy dysfunction and cGAS-Sting activation
Researchers found that polystyrene nanoplastics cause premature aging in human muscle cells by disrupting the internal skeleton of cells and impairing the cleanup of damaged mitochondria. The nanoplastics made the cell's structural framework too rigid, which blocked normal cell signaling and triggered an inflammatory aging response. This study suggests that nanoplastic exposure could contribute to muscle weakness and age-related muscle loss in humans.
Structural and Functional Characteristics of Microplastic Associated Biofilms in Response to Temporal Dynamics and Polymer Types
Researchers found that biofilm structural and functional characteristics on microplastics differ significantly depending on polymer type (polyethylene, polypropylene, and polystyrene) and change over time, with implications for understanding microbial colonization and the plastisphere.