Papers

61,005 results
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Article Tier 2

Hypoxia in the Blue Mussel Mytilus chilensis Induces Transcriptome Shift Associated with Endoplasmic Reticulum Stress, Metabolism, and Immune Response.

Scientists used gene expression analysis to study how low-oxygen conditions affect the blue mussel Mytilus chilensis at the molecular level. Researchers found that hypoxia triggered stress responses in the mussels' gills, digestive glands, and muscles, including cellular stress pathways, metabolic shifts, and immune changes. The study highlights how climate-driven oxygen depletion in coastal waters can stress economically important shellfish species.

2024 Preprints.org 5 citations
Article Tier 2

Interactive Immunomodulation in the Mediterranean Mussel Mytilus galloprovincialis Under Thermal Stress and Cadmium Exposure

Combined exposure to elevated temperature and cadmium in Mediterranean mussels triggered complex interactive effects on immune and antioxidant systems, with simultaneous stressors producing non-additive responses that highlight the difficulty of predicting organism health in multiply polluted warming seas.

2021 Frontiers in Marine Science 18 citations
Article Tier 2

Using Biometrics, Behavioral Observations, and Multiple Molecular Techniques to Assess the Impacts of Changes in Temperature and Salinity on the Common Bay Mussel (Mytilus trossulus)

This study used multiple molecular and physiological techniques to assess how the common bay mussel responds to changes in temperature and salinity, providing baseline data for understanding climate change impacts. Mussels are also used as sentinel organisms for monitoring microplastic contamination in coastal waters.

2023
Article Tier 2

Effects of Ocean Acidification, Hypoxia, and Warming on the Gut Microbiota of the Thick Shell Mussel Mytilus coruscus Through 16S rRNA Gene Sequencing

Researchers found that combined ocean acidification, hypoxia, and warming significantly altered the gut microbiota of the thick shell mussel Mytilus coruscus, disrupting microbial community structure and potentially compromising host health under future climate scenarios.

2021 Frontiers in Marine Science 35 citations
Article Tier 2

Differential responses of selectively bred mussels (Perna canaliculus) to heat stress—survival, immunology, gene expression and microbiome diversity

This study examined how selectively bred green-lipped mussels respond to heat stress, finding that genetic background significantly influenced survival rates, immune responses, and gene expression during heat challenges. While not directly about microplastics, the research is relevant because environmental stressors like microplastic pollution can compound heat stress effects on shellfish. Understanding how marine organisms cope with stress helps predict how additional pressures from plastic pollution might affect seafood species.

2024 Frontiers in Physiology 15 citations
Article Tier 2

Starvation shrinks the mussel foot secretory glands and impairs the byssal attachment

Researchers investigated the effect of starvation on byssal attachment in the hard-shelled mussel Mytilus coruscus, finding through histological analysis and gene expression studies that 7–21 days of starvation shrinks foot secretory glands and reduces expression of mussel foot proteins, impairing byssus secretion and substrate attachment.

2022 Frontiers in Marine Science 9 citations
Article Tier 2

Responses of Mytilus galloprovincialis in a Multi-Stressor Scenario: Effects of an Invasive Seaweed Exudate and Microplastic Pollution under Ocean Warming

Researchers exposed mussels to a combination of invasive seaweed exudate, polyethylene microplastics, and elevated temperatures to study their combined effects. The study found that simultaneous exposure to all three stressors greatly reduced byssal thread production and depleted antioxidant defenses in gill tissue, suggesting that multiple environmental stressors can amplify harmful effects on marine organisms.

2023 Toxics 9 citations
Article Tier 2

Impacts of microplastics exposure on mussel (Mytilus edulis) gut microbiota

Researchers exposed marine mussels (Mytilus edulis) to microplastics and analyzed changes to their gut microbiota, finding significant shifts in microbial community composition that could affect digestion, immunity, and overall health.

2020 The Science of The Total Environment 111 citations
Article Tier 2

Physiological and transcriptome analysis of Mytilus coruscus in response to Prorocentrum lima and microplastics

The combined effects of diarrhetic shellfish toxin and microplastics on the mussel Mytilus coruscus were assessed at physiological and transcriptomic levels, revealing synergistic disruption of immune function, antioxidant responses, and metabolic pathways. The study provides molecular-level evidence of interactive toxicity between two common coastal contaminants.

2022 Frontiers in Marine Science 18 citations
Meta Analysis Tier 1

Exploring the Potential of Metatranscriptomics to Describe Microbial Communities and Their Effects in Molluscs

Metatranscriptomics revealed a more complete picture of mussel microbiomes — including bacteria, viruses, fungi, and protozoans — than traditional 16S sequencing alone. The approach also identified host genes whose expression changed with pathogen load, providing new insights into how molluscs respond to microbial infections.

2022 International Journal of Molecular Sciences 11 citations
Article Tier 2

Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent

Researchers exposed freshwater mussels to industrial wastewater effluent containing elevated levels of copper, nickel, and zinc, then measured a panel of molecular stress markers in gill and digestive tissue. While most markers showed little change, increased nerve enzyme activity and heat shock protein expression were detected, suggesting mussels can serve as sensitive pollution bioindicators but require more research to standardize responses.

2021 Environmental Science and Pollution Research 36 citations
Article Tier 2

iTRAQ-Based Quantitative Proteomic Analysis Reveals Toxicity Mechanisms in Chlamys farreri Exposed to Okadaic Acid

Researchers used iTRAQ-based proteomics to reveal that okadaic acid exposure in scallops (Chlamys farreri) triggers oxidative stress, immune suppression, and disruption of cytoskeletal and energy metabolism pathways, providing mechanistic insights into shellfish toxicity during harmful algal blooms.

2021 Frontiers in Marine Science 5 citations
Article Tier 2

Profiling of microRNAs and mRNAs in marine mussel Mytilus galloprovincialis

Researchers used deep sequencing to profile microRNAs in the Mediterranean blue mussel Mytilus galloprovincialis, identifying 137 miRNA sequences — 104 conserved across species and 33 potentially novel — providing a genomic baseline for studying how this ecologically important species responds to environmental stressors.

2019 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 15 citations
Article Tier 2

Genomics and transcriptomics of the green mussel explain the durability of its byssus

Researchers used whole-genome and foot-specific transcriptomic analysis of the green mussel Perna viridis to identify genes responsible for byssus formation, finding that proteinase inhibitors and cross-linking proteins contribute to the exceptional durability and enzymatic resistance of mussel attachment threads.

2021 Scientific Reports 27 citations
Article Tier 2

Toxicological Impacts of Microplastics: Effects on Levels of Cellular Thiols in Mytilus galloprovincialis

Researchers investigated how microplastic exposure affects cellular thiol antioxidants in Mediterranean mussels, finding that short-term exposure altered glutathione and ovothiol levels, indicating oxidative stress as a key mechanism of microplastic toxicity in benthic species.

2023 Environmental Toxicology and Chemistry 8 citations
Article Tier 2

Unravelling biochemical responses in the species Mytilus galloprovincialis exposed to the antineoplastics ifosfamide and cisplatin under different temperature scenarios

Researchers exposed mussels to two common cancer-treatment drugs at current and warmer water temperatures and found that biochemical stress responses varied significantly depending on temperature. The study suggests that rising water temperatures may intensify how aquatic organisms react to pharmaceutical contaminants, highlighting the complex interplay between warming and chemical pollution in marine environments.

2024 The Science of The Total Environment 2 citations
Article Tier 2

Molecular mechanisms controlling physiological plasticity in marine mussels under the influence of natural and anthropogenic stress factors

This thesis project investigated the molecular mechanisms that help Mediterranean mussels cope with environmental stress, including both natural factors and emerging pollutants like microplastics. Understanding these stress responses could help predict how marine shellfish will fare as pollution and climate change intensify.

2021
Article Tier 2

Shallow-water mussels (Mytilus galloprovincialis) adapt to deep-sea environment through transcriptomic and metagenomic insights

Researchers placed common shallow-water mussels in deep-sea conditions and found that within just 10 days, the mussels' gene activity and gut microbiome shifted to closely resemble those of native deep-sea mussels — revealing a surprisingly rapid adaptive capacity driven by changes in both host biology and microbial communities.

2025 Communications Biology 3 citations
Article Tier 2

Impacts of marine heat extremes on bivalves

This review examines how increasingly frequent and intense marine heat waves threaten bivalve shellfish like mussels, oysters, and clams. Researchers found that extreme heat disrupts bivalves at multiple biological levels, from cellular stress responses to growth rates and survival, with mass mortality events already documented. The study warns that continued ocean warming poses serious risks to both marine ecosystems and global food security that depends on bivalve harvests.

2023 Frontiers in Marine Science 92 citations
Article Tier 2

Ocean Warming May Enhance Biochemical Alterations Induced by an Invasive Seaweed Exudate in the Mussel Mytilus galloprovincialis

Researchers found that elevated ocean temperatures amplified the biochemical disruptions caused by exudates from the invasive red seaweed Asparagopsis armata in the mussel Mytilus galloprovincialis. The findings suggest that ocean warming may worsen the impacts of biological invasions on native marine filter feeders.

2021 Toxics 9 citations
Article Tier 2

The combined effects of polystyrene microplastics and temperature stress on Mytilus galloprovincialis, Lamarck, 1819

Researchers investigated the combined effects of polystyrene microplastics and rising water temperatures on Mediterranean mussels. The study found that microplastic exposure amplified temperature-related stress, leading to increased mortality, greater oxidative damage, and more severe tissue changes, suggesting that these two environmental stressors interact to worsen harm to marine organisms.

2026 Marine Pollution Bulletin
Article Tier 2

The native mussel Mytilus chilensis genome reveals adaptative molecular signatures facing the marine environment

Researchers sequenced and analyzed the genome of the native Chilean blue mussel Mytilus chilensis, identifying adaptive molecular signatures that reflect the species' responses to diverse marine environmental conditions, with implications for understanding resilience in an aquaculture species reliant on wild seed collection.

2022 2 citations
Article Tier 2

Single and repetitive microplastics exposures induce immune system modulation and homeostasis alteration in the edible mussel Mytilus galloprovincialis

Researchers examined transcriptome-wide gene expression changes in Mediterranean mussels after single and repeated microplastic exposures, finding significant immune system modulation and disruption of cellular homeostasis. The study suggests that both short-term and chronic microplastic exposure can alter immune regulation pathways in filter-feeding bivalves, with repeated exposures showing cumulative effects.

2018 Fish & Shellfish Immunology 192 citations
Article Tier 2

Copper-Induced Ionoregulatory Disturbance, Histopathology, and Transcriptome Responses in Freshwater Mussel (Anodonta woodiana) Gills

Researchers investigated copper toxicity in the freshwater mussel Anodonta woodiana, finding that sublethal exposure caused ionoregulatory disturbance, gill histopathology, and significant transcriptomic changes related to stress response and immune function.

2023 Fishes 10 citations