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61,005 resultsShowing papers similar to Preparation of Corn Peptides with Anti-Adhesive Activity and Its Functionality to Alleviate Gastric Injury Induced by Helicobacter pylori Infection In Vivo
ClearPolyethylene microplastics cooperate with Helicobacter pylori to promote gastric injury and inflammation in mice
Researchers investigated how polyethylene microplastics interact with the stomach bacterium Helicobacter pylori in mice. They found that H. pylori formed biofilms on microplastic surfaces, and that mice exposed to both microplastics and the bacteria developed more severe gastric inflammation than those exposed to either alone. The study suggests that microplastics may facilitate bacterial colonization in the stomach and amplify infection-related tissue damage.
Relationship Between Human Microbiome and Helicobacter pylori
This review explores the complex relationship between Helicobacter pylori, the bacterium that causes stomach ulcers, and the broader human gut microbiome. While not directly about microplastics, it provides important context because microplastic exposure is known to alter gut bacteria composition. Understanding how the gut microbiome interacts with specific pathogens is relevant to assessing whether microplastic-driven changes in gut bacteria could make people more vulnerable to infections.
Microplastics in our diet: complementary in vitro gut and epithelium models to understand their fate in the human digestive tract.
Researchers used complementary in vitro gut models to study how microplastics behave during human digestion, finding that digestive conditions alter microplastic surface properties and their interactions with gut cells. The work advances understanding of how ingested microplastics may affect the human digestive system.
Microplastic in Gastric Fasting Liquid and Associated Gastric Pathology
This study found microplastic particles in gastric fluid samples collected from patients undergoing routine stomach examinations, and noted associations between microplastic presence and gastric pathologies including H. pylori infection, intestinal metaplasia, and inflammation. The findings provide direct clinical evidence that microplastics accumulate in the human stomach and may be linked to gastric disease, though causality is not yet established. This is an important step toward understanding whether microplastic ingestion contributes to gastrointestinal health problems in humans.
Charge-dependent effects of nanoplastics on Helicobacter pylori virulence and gastric pathogenesis
Researchers infected mice with Helicobacter pylori and co-exposed them to positively charged, negatively charged, or neutral polystyrene nanoplastics, then assessed gastric pathogenesis. Positively charged nanoplastics most strongly enhanced H. pylori virulence, gastric inflammation, and ulceration, identifying surface charge as a key determinant of how nanoplastics interact with gut pathogens.
The role of human intestinal mucus in the prevention of microplastic uptake and cell damage
Researchers studied how the mucus lining of the human intestine acts as a barrier against microplastic particles of different sizes and surface coatings. The mucus layer significantly reduced microplastic uptake by cells and protected against toxicity and inflammation. This study suggests that a healthy intestinal mucus layer is an important natural defense against the harmful effects of swallowed microplastics.
The microplastic-crisis: Role of bacteria in fighting microplastic-effects in the digestive system
This review examines how microplastics affect the human digestive system and explores whether certain bacteria could help counteract the damage. Microplastics disrupt the gut by altering microbial communities, interfering with digestive enzymes, and damaging the protective mucus lining. The authors highlight the potential for probiotic bacteria to bind to microplastics, reduce inflammation, and help repair the gut environment, offering a possible protective strategy against microplastic-related digestive harm.
Micro(nano)plastics in food system: potential health impacts on human intestinal system.
This review assessed how micro(nano)plastics in the human food system reach the intestine and accumulate in the gut, summarizing evidence that they can alter intestinal barrier function, trigger inflammation, and disrupt the gut microbiome, with implications for long-term digestive health.
Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models
Researchers studied how the human digestive process transforms polystyrene microplastics and affects their intestinal toxicity using in vitro Caco-2 cell models. The study found that digestion formed a corona on microplastic surfaces without altering their chemical composition, and that smaller particles (100 nm) showed higher toxicity than larger ones (5 micrometers) regardless of digestive treatment.
Protein Corona Stability and Removal from PET Microplastics: Analytical and Spectroscopic Evaluation in Simulated Intestinal Conditions
Researchers studied how proteins from intestinal fluids form a coating, called a corona, on PET microplastics and how stable that coating is under different cleaning treatments. They found that the protein corona is highly persistent and resists oxidative and surfactant treatments, with only a combined alkaline-surfactant protocol effectively removing it. The findings are important because protein coatings on microplastics can alter how the particles interact with biological tissues and may affect the accuracy of analytical detection methods.
Investigation of Microplastics in Digestion System: Effect on Surface Microstructures and Probiotics
Researchers investigated how the digestive system affects five common microplastic types and found that digestion altered the surface microstructures of the particles while also negatively impacting probiotic bacteria, suggesting potential health risks from ingested microplastics.
Biological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells.
Researchers exposed human intestinal organoid-derived epithelial tissue models with and without M cells to polystyrene micro- and nano-plastics, finding that nano-plastics caused greater disruption of barrier integrity and uptake than micro-plastics, and that M cell-containing models showed enhanced particle translocation compared to standard epithelial models.
Fate of microplastics in human digestive in vitro environment and study of the dialogue between epithelium, microbiota and mucus
Researchers used an in vitro human digestive model to track the fate of microplastics through simulated gastrointestinal conditions, investigating how MPs interact with digestive physico-chemical parameters, the epithelium, gut microbiota, and mucus layer, with particular attention to the vulnerable infant population.
Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size
Researchers examined how different sizes of polystyrene nanoplastics affect human stomach cells in the laboratory. They found that smaller nanoplastics were more readily taken up by the cells and caused greater damage, including increased oxidative stress and reduced cell survival. The study suggests that nanoplastic particle size plays a critical role in determining their potential impact on gastrointestinal health.
Effects of Polylactic Acid-nanoplastics on the Intestinal Barrier: in Vitro Analysis on Human Epithelial Cells
PLA nanoplastics were applied to human intestinal epithelial cell monolayers in vitro, finding that they increased paracellular permeability, reduced tight junction protein expression, and triggered inflammatory cytokine release, suggesting biodegradable plastics compromise intestinal barrier function.
Elucidating the Size‐Dependency of In Vitro Digested Polystyrene Microplastics on Human Intestinal Cells Health and Function
Polystyrene microplastics of different sizes were subjected to simulated in vitro digestion and then applied to human intestinal cells, with smaller particles causing greater disruption to cell health and barrier function than larger ones. The results suggest that the smallest microplastics reaching the human gut pose the greatest risk to intestinal integrity.
Toxicity of true-to-life microplastics to human iPSC-derived intestinal epithelia correlates to their protein corona composition
Using a human intestinal cell model, researchers showed that real-world microplastics from common products (like PET bottles and PVC) damaged the gut lining, increased harmful reactive oxygen species, and triggered inflammatory immune responses. Importantly, the standard polystyrene microplastics commonly used in lab studies did not cause these effects, suggesting that most research may be underestimating the true danger of microplastics. The type of protein coating that forms on each plastic's surface in the body determines how toxic it is to the gut.
Fate and impact of microplastics in in vitro human digestive environment and dialogue between epithelium, gut microbiota and mucus
This study used laboratory models of the human digestive system to track what happens to microplastics as they pass through the gut, and how they interact with gut bacteria and the mucus lining. The findings provide insight into how microplastics may disrupt the gut environment and potentially affect human health.
[Effect of microand nanoplastics on the gastrointestinal mucosa and intestinal microbiome].
This review examines how micro- and nanoplastics entering through the food chain affect the gastrointestinal tract, finding evidence of disruption to gut mucosal integrity and intestinal microbiome composition, with implications for digestive health and systemic immune function.
The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages
When microplastics pass through the digestive system, stomach and intestinal proteins coat them in a layer called a "protein corona" that makes immune cells absorb the smallest particles up to six times more readily than undigested ones. This finding means that the body's own digestive process may actually increase how much microplastic gets taken up by immune cells, which is important for accurately assessing health risks from swallowed plastics.
Aggregation kinetics of polystyrene nanoplastics in gastric environments: Effects of plastic properties, solution conditions, and gastric constituents
Researchers studied how polystyrene nanoplastics clump together (aggregate) inside simulated human stomach fluid under conditions mimicking fasting and different feeding states. They found that smaller particles aggregate faster, lower stomach pH accelerates clumping, and stomach proteins coat the plastic particles and dramatically change how they behave — findings that matter for understanding how nanoplastics travel through the human digestive system after ingestion.
Impact of a real food matrix and in vitro digestion on properties and acute toxicity of polystyrene microparticles
Researchers examined how interaction with milk as a real food matrix and subsequent digestion affects the properties and toxicity of polystyrene microparticles. The study found that milk proteins form a corona on the particles that alters their surface charge and behavior, suggesting that the food context significantly influences how microplastics behave in the gastrointestinal tract.
In vitro digestion of microplastics in human digestive system: Insights into particle morphological changes and chemical leaching
Researchers simulated human digestion on four common types of microplastics and found that stomach acid and digestive enzymes changed the particles' shape, surface texture, and caused them to release chemical additives. The study shows that microplastics are not inert once swallowed -- they are actively transformed in the gut, which could increase their ability to interact with intestinal tissues and release potentially harmful chemicals.
Microplastics (MPs): Fate in in vitro human digestive environment and study of the dialogue between epithelium, microbiota and mucus
This study examined what happens to microplastics as they pass through the human digestive system in vitro, studying interactions between plastic particles, gut microbiota, and intestinal mucus. Understanding how the gut processes microplastics is a key step in evaluating their potential health effects.